Melatonin protects against piroxicam‐induced gastric ulceration

Bandyopadhyay, Debashis; Ghosh, Gautam; Bandyopadhyay, Arun; Reíter, Russel J.

doi:10.1111/j.1600-079x.2004.00118.x

Cited by 59 publications

(60 citation statements)

References 63 publications

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“…Reduced GSH content (as acid soluble sulfhydryl) was estimated by its reaction with DTNB (Ellman’s reagent) following the method of Sedlac and Lindsey [30] with some modifications [29]. Cardiac tissue was homogenized (10%) in 2 m m ice‐cold ethylenediaminetetraacetic acid (EDTA).…”

Section: Methodsmentioning

confidence: 99%

Melatonin protects against isoproterenol‐induced myocardial injury in the rat: antioxidative mechanisms

Mukherjee

Roy

Bandyopadhyay

et al. 2010

Journal of Pineal Research

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The present study was undertaken to explore the protective effect of melatonin against isoproterenol bitartrate (ISO)-induced myocardial injury in rat. Treatment of rats with ISO increased the level of lipid peroxidation products and decreased the reduced glutathione levels in cardiac tissue indicating that this synthetic catecholamine induces oxidative damage following oxidative stress. Pretreatment of ISO-injected rats with melatonin at a dose of 10 mg/kg body weight, i.p. prevented these changes. Additionally, melatonin also restored the activities and the levels of antioxidant enzymes which were found to be altered by ISO treatment. Treatment of rats with ISO resulted into an increased generation of hydroxyl radicals with melatonin pretreatment significantly reducing their production. Finally, treatment of rats with ISO caused a lowering of systolic pressure with reduced cardiac output and diastolic dysfunction whereas melatonin pretreatment significantly restored many of these parameters to normal. The findings document melatonin's ability to provide cardio protection at a low pharmacological dose. Melatonin has virtually no toxicity which raises the possibility of this indole being a therapeutic treatment for ischemic heart disease.

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Section: Methodsmentioning

confidence: 99%

Melatonin protects against isoproterenol‐induced myocardial injury in the rat: antioxidative mechanisms

Mukherjee

Roy

Bandyopadhyay

et al. 2010

Journal of Pineal Research

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“…The • OH generated in the myocardium were measured as described earlier using dimethyl sulphoxide (DMSO) as an • OH scavenger [29]. The rats were divided into six groups; vehicle control, T3‐treated, T3 with melatonin or vitamin E treated and melatonin or vitamin E treated alone.…”

Section: Methodsmentioning

confidence: 99%

Melatonin protects against oxidative damage and restores expression of GLUT4 gene in the hyperthyroid rat heart

Ghosh

Kyle

Maity

et al. 2006

Journal of Pineal Research

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To understand the mechanism of cardiovascular dysfunction in the hyperthyroid condition, the role of oxidative stress was examined in rats treated with 3,5,3'-triiodo-l-thyronine (T3). Treatment of rats daily with T3 (8 microg/100 g BW) for 15 days resulted in an increase in heart weight to body weight ratio, which was ameliorated by antioxidants, melatonin (2 mg/100 g BW) or vitamin E (4 mg/100 g BW). Both melatonin and vitamin E also inhibited rises of lipid peroxidation and hydroxyl radical generation and prevented the inhibition of Cu,Zn-superoxide dismutase in the hypertrophic heart. The expression of the glucose transporter, GLUT4, was reduced in response to T3, which was completely restored by melatonin and partially by vitamin E. However, neither antioxidant prevented down regulation of peroxisome proliferator-activated receptor-alpha in the hyperthyroid heart. Furthermore, the reduced level of myocyte enhancer factor-2, a regulator of GLUT4 transcription was restored completely by melatonin and partially by vitamin E treatment. Glucose uptake in hypertrophic left ventricular cells was also restored by these antioxidants. The expression of B-type natriuretic peptide, a marker of heart failure, was significantly increased by T3 and ameliorated by melatonin or vitamin E treatments. In general, the beneficial effects of melatonin given as a co-treatment with T3 were better than those induced by vitamin E. These data show that melatonin ameliorates hypertrophic growth of the myocardium induced by hyperthyroidism and provide an insight into the mechanism of reactive oxygen species-mediated down regulation of metabolically important genes such as GLUT4 in the heart.

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“…This may be important since administration of ranitidine and omeprazole at lower doses itself would reduce the severity of their side effects. Very recently, we have demonstrated melatonin's gastroprotective ability against piroxicam-induced gastric damage and the findings raise the possibility of melatonin being considered as a cotherapy with piroxicam or other NSAIDs in reducing the gastropathy when long-term use of these non-steroidal agents are unavoidable [199] Thus, these findings when considered in the light of the observations reported herein, suggest that melatonin should be tested in co-administration studies with other drugs to either increase their efficacy or reduce their toxicity. When biomedical scientists are looking for a natural, safer and a non-toxic agent(s) which can be used to treat the conditions of hyperacidity and gastric ulceration, the emergence of gastro-protective properties of melatonin through intensive research appears promising.…”

Section: Rosmentioning

confidence: 96%

“…Ulceration of the gastrointestinal tract is associated with the overproduction of 5-HT, which elicits vasoconstriction of blood vessels by activation of 5-HT 2 receptors and causes a decrease of blood flow resulting in mucosal ischemia, [199] congestion, and increased free radical production and lesion formation in the gastric mucosa [132]. Melatonin was shown to partially reverse the serotonin-induced aggravation of ethanol ulceration in rat stomach by increasing mucosal blood flow [133].…”

Section: Protective Role Of Melatonin In Stress and Drug-induced Gastmentioning

confidence: 99%

Reactive Oxygen Species-Induced Gastric Ulceration: Protection By Melatonin

Bandyopadhyay¹,

Chattopadhyay

2006

CMC

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Gastric hyperacidity and ulceration of the stomach mucosa due to various factors are serious health problems of global concern. Although the mechanism of acid secretion from the parietal cells is now well understood, the processes involved in gastric ulceration are still not clear. Among the various causes of gastric ulceration, lesions caused by stress, alcohol consumption, Helicobacter pylori and due to use of non-steroidal anti-inflammatory drugs have been shown to be mediated largely through the generation of reactive oxygen species, especially the hydroxyl radical. A number of excellent drugs, developed over the decades, have proven useful in controlling hyperacidity and ulceration although their long-term use is reported to be associated with various side effects. Hence the investigations continue with an objective to find a compound possessing anti-secretory, anti-ulcer and antioxidant properties which will serve as a therapeutic agent to reduce gastric hyperacidity and ulcers. This article describes the role of reactive oxygen species in gastric ulceration, briefly presents a note on the currently available drugs controlling them, and focuses on the role of melatonin, a pineal secretory product, in protecting against gastric lesions. In experimental studies, melatonin has been shown to be effective in reducing mucosal breakdown and ulcer formation in a wide variety of situations. Additionally, the low toxicity of melatonin supports further investigation of this molecule as a promising gastro-protective agent. Finally, we include a commentary on how melatonin research with respect to gastric pathophysiology can move forward with a view to eventually using this indole as a therapeutic agent alone or in combination with the existing drugs to control gastric ulceration in humans in order to increase their efficacy and/or to reduce their side effects.

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Melatonin protects against piroxicam‐induced gastric ulceration

Cited by 59 publications

References 63 publications

Melatonin protects against isoproterenol‐induced myocardial injury in the rat: antioxidative mechanisms

Melatonin protects against isoproterenol‐induced myocardial injury in the rat: antioxidative mechanisms

Melatonin protects against oxidative damage and restores expression of GLUT4 gene in the hyperthyroid rat heart

Reactive Oxygen Species-Induced Gastric Ulceration: Protection By Melatonin

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