Melatonin-producing function of the pineal gland in elderly patients with hypertensive disease: Age peculiarities

Shatilo, V. B.; Bondarenko, E. V.; Antoniuk-Shcheglova, I. A.

doi:10.1134/s2079057011030131

Cited by 7 publications

(8 citation statements)

References 8 publications

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“…Several studies support the beneficial role of melatonin in patients with MS. Melatonin treatment ameliorates MS in obese patients [144,145] as well as in bipolar and schizophrenic patients after treatment with second generation antipsychotics [146][147][148]. Melatonin administration normalizes MS in elder hypertensive patients [149] and improves enzymatic profile in patients with on alcoholic liver steatosis [151,152]. The combination of melatonin and zinc acetate, when used alone or in combination with metformin improved glycemic control in type 2 diabetic patients [153] and an inverse relationship between urinary 6sulfatoxy melatonin excretion and insulin levels and insulin resistance was reported in healthy women in the Nurses' Health Study cohort [166].…”

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confidence: 99%

Melatonin, mitochondria, and the metabolic syndrome

Cardinali

Vigo

2017

Cell. Mol. Life Sci.

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A number of risk factors for cardiovascular disease including hyperinsulinemia, glucose intolerance, dyslipidemia, obesity, and elevated blood pressure are collectively known as metabolic syndrome (MS). Since mitochondrial activity is modulated by the availability of energy in cells, the disruption of key regulators of metabolism in MS not only affects the activity of mitochondria but also their dynamics and turnover. Therefore, a link of MS with mitochondrial dysfunction has been suspected since long. As a chronobiotic/cytoprotective agent, melatonin has a special place in prevention and treatment of MS. Melatonin levels are reduced in diseases associated with insulin resistance like MS. Melatonin improves sleep efficiency and has antioxidant and anti-inflammatory properties, partly for its role as a metabolic regulator and mitochondrial protector. We discuss in the present review the several cytoprotective melatonin actions that attenuate inflammatory responses in MS. The clinical data that support the potential therapeutical value of melatonin in human MS are reviewed.

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confidence: 99%

Melatonin, mitochondria, and the metabolic syndrome

Cardinali

Vigo

2017

Cell. Mol. Life Sci.

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“…Several studies support the beneficial role of melatonin in patients with MS. Melatonin treatment ameliorates MS in obese patients [126;127]as well as in bipolar and schizophrenic patients after treatment with second generation antipsychotics [128][129][130]. Melatonin administration normalizes MS in elder hypertensive patients [140] and improves enzymatic profile in patients with on alcoholic liver steatosis [131;132]. The combination of melatonin and zinc acetate, when used alone or in combination with metformin improved glycemic control in type 2 diabetic patients [133] and an inverse relationship between urinary 6-sulfatoxy melatonin excretion and insulin levels and insulin resistance was reported in healthy women in the Nurses' Health Study cohort [141].…”

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confidence: 99%

Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment Studies

2016

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The metabolic syndrome (MS) is a collection of risk factors for cardiovascular disease, including obesity, hypertension, hyperinsulinemia, glucose intolerance and dyslipidemia. MS is associated with low-grade inflammation of the white adipose tissue, which can subsequently lead to insulin resistance, impaired glucose tolerance and diabetes. Adipocytes secrete proinflammatory cytokines as well as leptin and trigger a vicious circle which leads to additional weight gain largely as fat. The imbalance between inflammatory and anti-inflammatory signals is crucial to aging. Healthy aging can benefit from melatonin, a compound known to possess direct and indirect antioxidant properties, to have a significant protective effect on mitochondrial function, to enhance circadian rhythm amplitudes, to modulate the immune system and to exhibit neuroprotective actions. Melatonin levels decrease in the course of senescence and are more strongly reduced in diseases related to insulin resistance. This short review article analyzes the multiple protective actions of melatonin that are relevant to the attenuation of inflammatory responses and progression of inflammaging and how melatonin is effective to curtail MS in animal models of hyperadiposity. The clinical data supporting the possible therapeutic use of melatonin in human MS are also reviewed. Since attention has been focused on the development of potent melatonin analogs with prolonged effects (ramelteon, agomelatine, tasimelteon, piromelatine) and in clinical trials these analogs were administered in doses considerably higher than those usually employed for melatonin, clinical trials on melatonin in the range of 50-100 mg/day are needed to further assess its therapeutic value in MS.

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“…A study using melatonin receptor knock-out mice has indicated an active role of these receptors in the regulation of blood glucose (Muhlbauer et al, 2009). It is also mentioned that melatonin administration normalized metabolic syndrome in elderly hypertensive patients via its receptors (Shatilo et al, 2010).…”

Section: Melatonin Diabetes and Obesitymentioning

confidence: 99%

Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19

El-Missiry

Othman

2020

European Journal of Pharmacology

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Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre-including this research content-immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.

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Melatonin-producing function of the pineal gland in elderly patients with hypertensive disease: Age peculiarities

Cited by 7 publications

References 8 publications

Melatonin, mitochondria, and the metabolic syndrome

Melatonin, mitochondria, and the metabolic syndrome

Inflammaging, Metabolic Syndrome and Melatonin: A Call for Treatment Studies

Melatonin is a potential adjuvant to improve clinical outcomes in individuals with obesity and diabetes with coexistence of Covid-19

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