Melatonin Plays a Role as a Mediator of Nocturnal Pain in Patients with Shoulder Disorders

Ha, Eunyoung; Lho, Yunmee; Seo, Hyuk-Jun; Cho, Chul-Hyun

doi:10.2106/jbjs.m.01011

Cited by 30 publications

(32 citation statements)

References 32 publications

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“…Finally, recent basic science studies have contributed to our evolving understanding of pain and sleep disturbance associated with rotator cuff tears. Ha et al 10 found that melatonin levels, which fluctuate in accordance with the circadian rhythm, may play a role in increasing the inflammatory response in the shoulder at night. Terabayashi et al 24 demonstrated that patients with rotator cuff tears and night pain had increased blood flow in the anterior humeral circumflex artery.…”

Section: Discussionmentioning

confidence: 99%

Do Magnetic Resonance Imaging Characteristics of Full-Thickness Rotator Cuff Tears Correlate With Sleep Disturbance?

Reyes

Hull

Kurth

et al. 2017

Orthopaedic Journal of Sports Medicine

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Background:Many patients with rotator cuff tears suffer from nocturnal shoulder pain, resulting in sleep disturbance.Purpose:To determine whether rotator cuff tear size correlated with sleep disturbance in patients with full-thickness rotator cuff tears.Study Design:Cross-sectional study; Level of evidence, 3.Methods:Patients with a diagnosis of unilateral full-thickness rotator cuff tears (diagnosed via magnetic resonance imaging [MRI]) completed the Pittsburgh Sleep Quality Index (PSQI), a visual analog scale (VAS) quantifying their shoulder pain, and the American Shoulder and Elbow Surgeons (ASES) questionnaire. Shoulder MRI scans were analyzed for anterior-posterior tear size (mm), tendon retraction (mm), Goutallier grade (0-4), number of tendons involved (1-4), muscle atrophy (none, mild, moderate, or severe), and humeral head rise (present or absent). Bivariate correlations were calculated between the MRI characteristics and baseline survey results.Results:A total of 209 patients with unilateral full-thickness rotator cuff tears were included in this study: 112 (54%) female and 97 (46%) male (mean age, 64.1 years). On average, shoulder pain had been present for 24 months. The mean PSQI score was 9.8, and the mean VAS score was 5.0. No significant correlations were found between any of the rotator cuff tear characteristics and sleep quality. Only tendon retraction had a significant correlation with pain.Conclusion:Although rotator cuff tears are frequently associated with nocturnal pain and sleep disruption, this study demonstrated that morphological characteristics of full-thickness rotator cuff tears, such as size and tendon retraction, do not correlate with sleep disturbance and have little to no correlation with pain levels.

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Section: Discussionmentioning

confidence: 99%

Do Magnetic Resonance Imaging Characteristics of Full-Thickness Rotator Cuff Tears Correlate With Sleep Disturbance?

Reyes

Hull

Kurth

et al. 2017

Orthopaedic Journal of Sports Medicine

View full text Add to dashboard Cite

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“…However, Cho et al found no significant differences between patients with shoulder pathologies (including those with RC tears, adhesive capsulitis, and calcific tendinitis) in terms of mean scores on the PSQI and VAS [22]. The factors explaining the increased levels of nocturnal pain and the higher PSQI scores in patients with RC tears are still debated [23]. Synovial inflammation (in the glenohumeral joint and subacromial space) and increased levels of proinflammatory and pain-related cytokines are common features of shoulder disorders, including RC tears [4,24].…”

Section: Discussionmentioning

confidence: 99%

Sleep Disturbance and Rotator Cuff Tears: A Systematic Review

et al. 2019

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Background and Objectives: Sleep disorders are one of the most common complaints of patients with rotator cuff (RC) tears. However, potential correlations between the treatment of RC tears and the causal factors of sleep disorders are still under discussion. The aim of this review is to evaluate quality of sleep in patients before and after surgery for RC tears and to identify which factors affected patients’ sleep. Materials and Methods: A systematic review was conducted. To provide high quality of the review, the included studies were evaluated with the standardized tool “Quality Assessment Tool for Quantitative Studies” developed by the Effective Public Health Practice Project. Results: The search strategy yielded 78 articles. After duplicate removal and titles, abstracts and full-texts review, four studies were included in the systematic review. Concerning shoulder function, the most frequently reported scale was the Simple Shoulder Test (SST). Regarding sleep quality, the most frequently reported score was the Pittsburgh Sleep Quality Index (PSQI). Conclusion: We found that the majority of patients with RC tears had a sleep disturbance, especially before surgery with a general improvement in sleep quality post-operatively. Moreover, sleep quality was correlated with pain and it also seems that factors as comorbidities, obligatory position during night time, preoperative and prolonged postoperative use of narcotics and psychiatric issues may play an important role in sleep quality.

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“…IL-2 induces lymphocytes proliferation by autocrine and paracrine actions on the immune cells (Carrillo-Vico et al, 2005). Physiological melatonin concentration has been suggested to influence IL-2 and IL-6 secretion from the immune cells (Garcia-Mauriiio et al, 1997;Carrillo-Vico et al, 2003) via binding to its receptors present on the PBMCs (Ha et al, 2014). Recently, it has been reported that melatonin induces the secretion of IL-2 to potentiate the proliferative capacity of PBMCs in goats (Singh and Haldar, 2016).…”

Section: Discussionmentioning

confidence: 99%

Supplementation of corn seed with regular diet modulates immune function and antioxidant status in Capra hircus

Singh

Haldar

2017

Animal Physiology Nutrition

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Melatonin modulates the functional activation of antioxidative enzymes to maintain the oxidant-antioxidant balance in the physiological system. Melatonin administration via subcutaneous injection increases endogenous melatonin concentration that has been used to modulate the immune function in rodents and reproductive activity in small ruminant like goats. However, to date, no report exist which could suggest the effect of corn seed supplementation on the endogenous melatonin concentration and its impact on cellular-immune function and antioxidative enzymes activity in any small ruminant like goats. Therefore, in this study, Zea mays (corn seeds), as source of melatonin, were supplemented with regular diet to explore its impact on endogenous melatonin concentration in goat, Capra hircus. Zea mays supplementation with regular diet for 40 days significantly elevated the endogenous melatonin concentration, proliferative response of peripheral blood mononuclear cells and antioxidative enzymes activity along with total antioxidant capacity of the plasma. An increase in circulatory IL-2 and IL-6 level along with declined TNF-α, malondialdehyde and nitric oxide was noted with elevated endogenous melatonin concentration. In conclusion, it might be suggested that corn seed could be used as supplement to modulate endogenous melatonin concentration that may improve cellular-immune function and antioxidant status. The corn seed might also be included as nutraceutical in regular diet to maintain immune-antioxidant homoeostasis in other species.

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Melatonin Plays a Role as a Mediator of Nocturnal Pain in Patients with Shoulder Disorders

Abstract: Melatonin may be a therapeutic target of chronotherapy.

Cited by 30 publications

References 32 publications

Do Magnetic Resonance Imaging Characteristics of Full-Thickness Rotator Cuff Tears Correlate With Sleep Disturbance?

Do Magnetic Resonance Imaging Characteristics of Full-Thickness Rotator Cuff Tears Correlate With Sleep Disturbance?

Sleep Disturbance and Rotator Cuff Tears: A Systematic Review

Supplementation of corn seed with regular diet modulates immune function and antioxidant status in Capra hircus

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