Melatonin — More than Just a Pineal Hormone

Hardeland, Rüdiger

doi:10.26717/bjstr.2017.01.000351

Cited by 14 publications

(16 citation statements)

References 30 publications

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“…Nevertheless, the circulating melatonin level is predominantly provided by the pineal gland [10,11]. Pineal melatonin synthesis/secretion is stimulated by darkness and inhibited by exposure to light [12]. Intervention studies reported that melatonin can improve lipid profile [13], glycemic status [14], immune system function [15], anti-oxidative status [16], and inflammatory parameters [17].…”

Section: Introductionmentioning

confidence: 99%

Effects of Melatonin Supplementation On Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2019

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Melatonin is a physiological indoleamine secreted from the pineal gland into the bloodstream. This hormone has antioxidant effects in cardiovascular disease, but the evidence regarding its effects on blood pressure (BP) has not been conclusive. Therefore, we assessed the impact of melatonin supplementation on systolic BP (SBP) and diastolic BP (DBP) through a systematic review and meta—analysis of available randomized controlled trials (RCTs). Medline, Scopus, Web of Science, Cochrane library, and Google scholar (until May 2018) were searched to identify potential RCTs with information on melatonin supplementation and BP. Mean Differences (MD) were pooled using a random-effects model. Standard methods were used for assessment of heterogeneity, sensitivity analysis, and publication bias. Pooling 5 RCTs (6 treatment arms) together identified significant reduction for SBP (MD: −3.43 mmHg, 95% confidence interval (CI): −5.76 to −1.09, p=0.004) and DBP (MD: −3.33 mmHg, 95% CI: −4.57 to −2.08, p<0.001) after supplementation with melatonin compared with control treatment. The sensitivity analysis indicated that the results were robust. We did not observe any evidence regarding publication bias. The findings of this meta-analysis support the overall favorable effect of melatonin supplementation on BP regulation.

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Section: Introductionmentioning

confidence: 99%

Effects of Melatonin Supplementation On Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

et al. 2019

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“…Furthermore, melatonin acts by binding to cytoplasmic and nuclear proteins like calmodulin and RZR/ROR [26]. Due to its high lipophilic property, melatonin can penetrate different cells and tissues, and affect gene regulation [27]. Melatonin has interesting properties which make it potent protector against various oxidants and inflammatory agents.…”

Section: Melatoninmentioning

confidence: 99%

Mechanisms for Radioprotection by Melatonin; Can it be Used as a Radiation Countermeasure?

Amini

Mirtavoos-Mahyari

Motevaseli

et al. 2019

CMP

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“…Contrary to pineal melatonin synthesis, no substantial circadian differences were observed in the brain mitochondria, a finding that is not really surprising because a similar paucity of circadian fluctuations was also observed in other extrapineal sites of melatonin formation [57]. Notably, melatonin is formed in numerous tissues and cells [9,[57][58][59]. Therefore, mitochondrial production in conjunction with uptake from the circulation might well generate mitochondrial concentrations that suffice for physiological actions in these organelles.…”

Section: A Melatonin Receptor and Other Binding Sites In Mitochondriamentioning

confidence: 99%

Extended Signaling by Melatonin

Hardeland¹

2018

CCLSJ

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The whole spectrum of melatonin's actions cannot be directly deduced from its primary signaling via its membranebound G protein-coupled receptors. This is not so much a matter of possibly existing other binding sites, but rather of the control of other important regulators by melatonin. Therefore, secondary signaling by factors influenced by melatonin has to be taken into consideration, such as other humoral factors, components of circadian oscillators, sirtuins, and microRNAs. Transmission of microRNAs by exosomes contributes to the actions of melatonin. In plants, melatoninbinding proteins are being investigated, but additionally interactions with phytohormones are likely. The recent demonstration of melatonin formation in mitochondria of both plants and mammals as well as the presence of a mammalian mitochondrial melatonin receptor open new aspects of melatonin's intracellular actions.

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Melatonin — More than Just a Pineal Hormone

Cited by 14 publications

References 30 publications

Effects of Melatonin Supplementation On Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Effects of Melatonin Supplementation On Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Mechanisms for Radioprotection by Melatonin; Can it be Used as a Radiation Countermeasure?

Extended Signaling by Melatonin

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