Melatonin modulates copper-induced anxiety-like, depression-like and memory impairments by acting on hippocampal oxidative stress in rat

Lamtai, Mouloud; Zghari, Oussama; Azirar, Sofia; Ouakki, Sihame; Mesfioui, Abdelhalem; Hessni, Aboubaker El; Berkiks, Inssaf; Marmouzi, Ilias; Ouichou, Ali

doi:10.1080/01480545.2020.1858853

Cited by 21 publications

(18 citation statements)

References 65 publications

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“…Other researchers also reported the role of oxidative stress in cadmium tissue toxicity [7,8]. For example, Lamtai et al found that IP administration of cadmium chloride (1 mg/kg) for eight weeks promoted oxidative stress in hippocampus tissue via increasing the levels of Nitric Oxide (NO) and Lipid Peroxidation (LPO), while the activities of CAT and SOD were significantly decreased in the hippocampus [8]. These studies confirmed our results about cadmium-induced oxidative damage.…”

Section: Discussionsupporting

confidence: 88%

“…We found that cadmium administration increased oxidative stress in mice kidneys via increasing MDA and protein carbonyl levels and decreasing GSH depletion. Other researchers also reported the role of oxidative stress in cadmium tissue toxicity [7,8]. For example, Lamtai et al found that IP administration of cadmium chloride (1 mg/kg) for eight weeks promoted oxidative stress in hippocampus tissue via increasing the levels of Nitric Oxide (NO) and Lipid Peroxidation (LPO), while the activities of CAT and SOD were significantly decreased in the hippocampus [8].…”

Section: Discussionmentioning

confidence: 99%

“…It results from the overproduction of Reactive Oxygen Species (ROS) and the disability of endogenous antioxidants to neutralize them [6]. Previous studies also reported the role of oxidative stress in tissue damages induced by cadmium [7,8]. For example, Fouad et al reported that Intraperitoneal (IP) administration of cadmium chloride (2 mg/kg) resulted in testicular oxidative injury in rats via increasing Malondialdehyde (MDA) level, depleting Glutathione (GSH), and decreasing Superoxide Dismutase (SOD) and Catalase (CAT) activity [7].…”

Section: Introductionmentioning

confidence: 99%

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L-arginine Ameliorated Mitochondrial Oxidative Damage Induced by Sub-chronic Exposure to Cadmium in Mice Kidney

Shaki¹,

Teymoori²,

Motafeghi³

et al. 2021

PBR

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Background:Cadmium is a heavy metal that can cause various injuries in the body, including nephrotoxicity. L-Arginine is a metal chelator that can prevent oxidative damage caused by oxygen free radicals. Objectives:This study aimed to investigate the effect of L-arginine in inhibiting mitochondrial toxicity induced by subchronic cadmium exposure in the kidney of male mice. Methods: A total of 42 male mice were randomly divided into six groups (n=6): control (normal saline), cadmium (2 mg/kg), cadmium (2 mg/kg) plus three doses of L-arginine (50, 100, and 200 mg/kg) and finally cadmium (2 mg/kg) plus vitamin C (500 mg/kg). After 42 days, the animals were anesthetized with ketamine/xylazine. Their kidney tissues were removed, and mitochondrial fractions were isolated. Oxidative stress factors and mitochondrial damage parameters (MTT, swelling, and mitochondrial membrane potential) were measured in renal isolated mitochondria. Also, evaluation of Blood Urea Nitrogen (BUN) and Creatinine (Cr) tests were done. Results: Significant rise in BUN and Cr were observed in cadmium-treated mice (P<0.05). Cadmium enhanced oxidative stress in the kidney via increasing lipid peroxidation and oxidation of protein and glutathione. It caused significant mitochondrial dysfunction, mitochondrial membrane potential collapse, and swelling in isolated mitochondria (P<0.05). L-Arginine significantly ameliorated cadmium-induced oxidative stress and mitochondrial damage (P<0.05). Furthermore, a significant reduction in serum BUN and Cr were observed in L-arginine received group (P<0.05). Conclusion: The results showed that L-arginine has significant protective effects against cadmium-induced renal toxicity in male mice.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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L-arginine Ameliorated Mitochondrial Oxidative Damage Induced by Sub-chronic Exposure to Cadmium in Mice Kidney

Shaki¹,

Teymoori²,

Motafeghi³

et al. 2021

PBR

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“…In brief, rats were placed into motor activity measuring cages (50 cm × 50 cm × 50 cm, with detectors each 2.5 cm, OA-BioMed OMNIALVA ® , Mexico City, Mexico) for determining total number of movements, distance traveled, highest speed, and vertical movements as elsewhere [ 34 ]. Treatment were in a similar posology to those reported as active in rat memory evaluation [ 66 , 67 ].…”

Section: Methodsmentioning

confidence: 89%

“…daily for 28 days. On the same days, the remaining two groups were treated with melatonin (i.p., 10 mg/kg, 4.11 × 10 −5 mol) or borolatonin (i.p., 10 mg/kg, 2.71 × 10 −5 mol) in the same volume of vehicle [ 66 , 67 ]. All of the behavioral evaluations were carried out between 10:00 and 14:00 h.…”

Section: Methodsmentioning

confidence: 99%

Synthesis, In Silico, and Biological Evaluation of a Borinic Tryptophan-Derivative That Induces Melatonin-like Amelioration of Cognitive Deficit in Male Rat

Barrón-González

Rosales‐Hernández

Abad-García

et al. 2022

IJMS

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Preclinical and clinical evidence supports melatonin and its analogues as potential treatment for diseases involving cognitive deficit such as Alzheimer’s disease. In this work, we evaluated by in silico studies a set of boron-containing melatonin analogues on MT1 and MT2 receptors. Then, we synthesized a compound (borolatonin) identified as potent agonist. After chemical characterization, its evaluation in a rat model with cognitive deficit showed that it induced ameliorative effects such as those induced by equimolar administration of melatonin in behavioral tests and in neuronal immunohistochemistry assays. Our results suggest the observed effects are by means of action on the melatonin system. Further studies are required to clarify the mechanism(s) of action, as the beneficial effects on disturbed memory by gonadectomy in male rats are attractive.

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Melatonin Protects Against Titanium Oxide-Induced Neurotoxicity: Neurochemical, Neurobehavioral, and Histopathological Evidences

Sobhani

Tehrani

Sobhani

et al. 2022

Biol Trace Elem Res

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Melatonin modulates copper-induced anxiety-like, depression-like and memory impairments by acting on hippocampal oxidative stress in rat

Cited by 21 publications

References 65 publications

L-arginine Ameliorated Mitochondrial Oxidative Damage Induced by Sub-chronic Exposure to Cadmium in Mice Kidney

L-arginine Ameliorated Mitochondrial Oxidative Damage Induced by Sub-chronic Exposure to Cadmium in Mice Kidney

Synthesis, In Silico, and Biological Evaluation of a Borinic Tryptophan-Derivative That Induces Melatonin-like Amelioration of Cognitive Deficit in Male Rat

Melatonin Protects Against Titanium Oxide-Induced Neurotoxicity: Neurochemical, Neurobehavioral, and Histopathological Evidences

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