Melatonin menurunkan berat badan tetapi tidak menurunkan kadar TNF-α pada tikus wistar jantan yang diberi minyak jelantah selama 28 hari

Novianti, Anugrah; Dharmana, Edi; Widyastiti, Nyoman Suci

doi:10.14710/jgi.5.2.127-132

Cited by 1 publication

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“…Masyarakat Indonesia masih sangat menyukai makanan yang berlemak atau digoreng di berbagai tingkat usia, dan dilaporkan bahwa penggunaan minyak goreng mencapai 2,5 juta ton pertahun atau 12 kg perorang per tahun (Novianti et al, 2017). Berdasarkan survey 90% masyarakat masih menggunakan minyak goreng berulang 4-8 kali per hari (Siswanto, 2015).…”

Section: Pendahuluanunclassified

EKSTRAK RIMPANG KUNYIT (Curcuma longa Linn) MENURUNKAN PENYAKIT PERLEMAKAN HATI NON-ALKOHOLIK

Kaban

Sunarti²

2019

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The use of recycled frying oil or deep frying oil (DFO) lead to increase in free fatty acid, trans fatty acid and free radical compound. It can cause non-alcoholic fatty liver disease (NAFLD). a chronic liver disease cause the risk for cirrhosis and heart cancer. However, there is no medicine for preventing the disease. The present study was conducted to investigate the turmeric reduces steatosis hepatocyte of male Wistar rat NAFLD model. The study used experimental randomize post-test only control group design. The 24 samples consist of four treatment groups. Group I (control): normal diet + DFO (10 Î¼l/g/day on 6 times heating), Group II, III and IV: normal diet + DFO (10 Î¼l/g/day on 6 times heating)+ turmeric Extract (100, 200, and 400 mg/kg/day) by given for 30 days through oral induction. The results of Kruskal-Wallis test showed a significant difference between the four treatment groups (P= 0.019) .The results of Mann-Whitney test showed significant difference in steatosis hepatocyte between the control group (P1) and treatment group(P3) the dose of 200 mg/kg BW. This suggests that a dose of 200 mg/kg BW is an effective dose in decreasing hepatocyte steatosis.

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Section: Pendahuluanunclassified