Melatonin-mediated IGF-1/GLP-1 activation in experimental OCD rats: Evidence from CSF, blood plasma, brain and in-silico investigations

Icariin prevents methylmercury-induced experimental neurotoxicity: Evidence from cerebrospinal fluid, blood plasma, brain samples, and in-silico investigations

“…By simulating the docking process, it can explore different regions of the receptor and determine the most probable binding sites for ligand binding and subsequent activation, and allow investigation of the specific interactions between ligands and the receptor, such as hydrogen bonding, hydrophobic interactions, and electrostatic interactions [ 54 ]. These interactions play a vital role in receptor activation by stabilizing ligand-receptor complexes and transmitting signals within the receptor [ 55 , 56 ]. To find the binding interactions of the protocol drug icariin with our selected targets, HO-1 (PDB ID: 3HOK ) crystallographic receptor of human heme oxygenase ( https://www.rcsb.org/structure/3HOK ) [ 57 ].…”