Melatonin mediated antidepressant-like effect in the hippocampus of chronic stress-induced depression rats: Regulating vesicular monoamine transporter 2 and monoamine oxidase A levels

Stefanović, Bojana; Spasojević, Nataša; Jovanović, Predrag; Jasnić, Nebojša; Djordjević, Jelena; Dronjak, Sladjana

doi:10.1016/j.euroneuro.2016.07.005

Cited by 36 publications

(27 citation statements)

References 40 publications

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“…Our fi ndings here provide novel targets for exploring the molecular mechanisms by which melatonin is improving mental health modulating through dysfunctional noradrenergic synaptic transmission. Recently, we reported that reduced noradrenaline content was increased in the hippocampus of stressed rats treated with melatonin (28). The present results suggested that repeated treatment with melatonin might improve a reduced expression of α 1 -and β 2 -adrenoreceptors, and it was in a good correlation with increased noradrenaline in the hippocampus.…”

Section: Discussionsupporting

confidence: 71%

Melatonin modulate the expression of α1- and β2-adrenoceptors in the hippocampus of rats subjected to unpredictable chronic mild stress

Stefanović¹,

Spasojević²,

Jovanović³

et al. 2018

BLL

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Section: Discussionsupporting

confidence: 71%

Melatonin modulate the expression of α1- and β2-adrenoceptors in the hippocampus of rats subjected to unpredictable chronic mild stress

Stefanović¹,

Spasojević²,

Jovanović³

et al. 2018

BLL

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“…It was well established that melatonin hormone anti-depressive effects [14], therefore, the mode changes reported by those persons might be attributed to low melatonin. Such evidences were reported in light therapy for seasonal affective disorder which is a seasonal pattern of recurrent major depressive episodes that occurs in countries experience major changes among different seasons [15].…”

Section: Discussionmentioning

confidence: 99%

Light Pollution Associated with Delayed Sleep Time: A Major Hygienic Problem in Saudi Arabia

Ahmed¹,

Alogla²,

Ismael³

et al. 2017

JBBS

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Background: It was well established that exposure to nighttime light was responsible of a diverse negative health effect. Therefore, the aim of this study was to assess the epidemiologic exposure to artificial light at night time and negative health consequences that associated with prolonged nighttime lighting exposure. Methodology: This is a cross-sectional survey, involving a total of 266 Saudi residents living in the city of Hail, Northern KSA. Essential information regarding exposure to light at night time was obtained. Results: The overall incidence of nighttime light exposure in the present study was 65.8% for general population, was 61.5% males and was 38.5% for females. About 75.6% persons used to sleep for <6 hours and 36.8% individuals used to sleep on light exposure. Conclusion: Prolonged exposure to the light at nighttime is prevalent in Saudi Arabia. This exposure usually results from late sleep in the nighttime and the late awake in the daytime.

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“…However, a study on hippocampal slice cultures found melatonin induced dendritogenisis through Ca 2+ calmodulin‐dependent protein kinase II activation independent of MT 1 /MT 2 ; indicating melatonin may influence neuronal structures through other mechanisms (Dominguez‐Alonso, Valdes‐Tovar, Solis‐Chagoyan, & Benitez‐King, ). Melatonin has demonstrated capacity to preserve hippocampal monoamine handling in disease states, in particular noradrenaline, though this neuroprotective is unclear (Stefanovic et al, ). Finally, melatonin may also influence redox equilibrium.…”

Section: Resultsmentioning

confidence: 99%

“…In the setting of chronic ketamine administration in mice, melatonin increases hippocampal BDNF leading to phosphorylation of Akt and extracellular signal-regulated kinases 1 and 2 (ERK1/2) (prosurvival pathways) (Table 3) (Choudhury, Singh, Palit, Shukla, & Ganguly, 2016). These actions were found to be melatonin receptors (Stefanovic et al, 2016). Finally, melatonin may also influence redox equilibrium.…”

Section: Melatoninmentioning

confidence: 99%

Putative neuroprotective pharmacotherapies to target the staged progression of mental illness

Robertson

Coronado

Sethi

et al. 2019

Early Intervention Psych

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Aim: Neuropsychiatric disorders including depression, bipolar and schizophrenia frequently exhibit a neuroprogressive course from prodrome to chronicity. There are a range of agents exhibiting capacity to attenuate biological mechanisms associated with neuroprogression. This review will update the evidence for putative neuroprotective agents including clinical efficacy, mechanisms of action and limitations in current assessment tools, and identify novel agents with neuroprotective potential.Method: Data for this review were sourced from online databases PUBMED, Embase and Web of Science. Only data published since 2012 were included in this review, no data were excluded based on language or publication origin.Results: Each of the agents reviewed inhibit one or multiple pathways of neuroprogression including: inflammatory gene expression and cytokine release, oxidative and nitrosative stress, mitochondrial dysfunction, neurotrophin dysregulation and apoptotic signalling. Some demonstrate clinical efficacy in preventing neural damage or loss, relapse or cognitive/functional decline. Agents include: the psychotropic medications lithium, second generation antipsychotics and antidepressants; other pharmacological agents such as minocycline, aspirin, cyclooxygenase-2 inhibitors, statins, ketamine and alpha-2-delta ligands; and others such as erythropoietin, oestrogen, leptin, N-acetylcysteine, curcumin, melatonin and ebselen.Conclusions: Signals of evidence of clinical neuroprotection are evident for a number of candidate agents. Adjunctive use of multiple agents may present a viable avenue to clinical realization of neuroprotection. Definitive prospective studies of neuroprotection with multimodal assessment tools are required.

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Melatonin mediated antidepressant-like effect in the hippocampus of chronic stress-induced depression rats: Regulating vesicular monoamine transporter 2 and monoamine oxidase A levels

Cited by 36 publications

References 40 publications

Melatonin modulate the expression of α1- and β2-adrenoceptors in the hippocampus of rats subjected to unpredictable chronic mild stress

Melatonin modulate the expression of α1- and β2-adrenoceptors in the hippocampus of rats subjected to unpredictable chronic mild stress

Light Pollution Associated with Delayed Sleep Time: A Major Hygienic Problem in Saudi Arabia

Putative neuroprotective pharmacotherapies to target the staged progression of mental illness

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