Melatonin-mediated actions and circadian functions that improve implantation, fetal health and pregnancy outcome

Reiter, Russel J.; Sharma, Ramaswamy; DA Chuffa, Luiz Gustavo; Zuccari, Debora APC; Amaral, Fernanda G.; Cipolla-Neto, Jose

doi:10.1016/j.reprotox.2024.108534

Cited by 3 publications

(1 citation statement)

References 164 publications

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“…In pregnancies complicated by placental pathology and insufficiency, especially preeclampsia and gestational diabetes, there is an imbalance between the excessive production of reactive oxygen species (ROS) and defensive antioxidative mechanisms, such as maternal melatonin levels [92]. As recently revealed in a systematic review, the circadian pattern of melatonin secretion seems to be disrupted in these pathologies as shown by the reduced production of melatonin and lower expression of melatonin receptors [84,93].…”

Section: Maternal Factorsmentioning

confidence: 99%

Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition?

Häusler,

Lanzinger,

Sams

et al. 2024

Nutrients

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Breastfeeding is the most appropriate source of a newborn’s nutrition; among the plethora of its benefits, its modulation of circadian rhythmicity with melatonin as a potential neuroendocrine transducer has gained increasing interest. Transplacental transfer assures melatonin provision for the fetus, who is devoid of melatonin secretion. Even after birth, the neonatal pineal gland is not able to produce melatonin rhythmically for several months (with an even more prolonged deficiency following preterm birth). In this context, human breast milk constitutes the main natural source of melatonin: diurnal dynamic changes, an acrophase early after midnight, and changes in melatonin concentrations according to gestational age and during the different stages of lactation have been reported. Understudied thus far are the factors impacting on (changes in) melatonin content in human breast milk and their clinical significance in chronobiological adherence in the neonate: maternal as well as environmental aspects have to be investigated in more detail to guide nursing mothers in optimal feeding schedules which probably means a synchronized instead of mistimed feeding practice. This review aims to be thought-provoking regarding the critical role of melatonin in chrononutrition during breastfeeding, highlighting its potential in circadian entrainment and therefore optimizing (neuro)developmental outcomes in the neonatal setting.

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Section: Maternal Factorsmentioning

confidence: 99%

Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition?

Häusler,

Lanzinger,

Sams

et al. 2024

Nutrients

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Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review

de Almeida Chuffa,

Seiva,

Silveira

et al. 2024

Journal Cellular Physiology

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The endoplasmic reticulum (ER) is crucial for protein quality control, and disruptions in its function can lead to various diseases. ER stress triggers an adaptive response called the unfolded protein response (UPR), which can either restore cellular homeostasis or induce cell death. Melatonin, a safe and multifunctional compound, shows promise in controlling ER stress and could be a valuable therapeutic agent for managing the UPR. By regulating ER and mitochondrial functions, melatonin helps maintain cellular homeostasis via reduction of oxidative stress, inflammation, and apoptosis. Melatonin can directly or indirectly interfere with ER‐associated sensors and downstream targets of the UPR, impacting cell death, autophagy, inflammation, molecular repair, among others. Crucially, this review explores the mechanistic role of melatonin on ER stress in various diseases including liver damage, neurodegeneration, reproductive disorders, pulmonary disease, cardiomyopathy, insulin resistance, renal dysfunction, and cancer. Interestingly, while it alleviates the burden of ER stress in most pathological contexts, it can paradoxically stimulate ER stress in cancer cells, highlighting its intricate involvement in cellular homeostasis. With numerous successful studies using in vivo and in vitro models, the continuation of clinical trials is imperative to fully explore melatonin's therapeutic potential in these conditions.

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Preeclampsia: A comprehensive review

Ali,

Ahmed,

Memon

et al. 2024

Clinica Chimica Acta

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Melatonin-mediated actions and circadian functions that improve implantation, fetal health and pregnancy outcome

Cited by 3 publications

References 164 publications

Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition?

Melatonin in Human Breast Milk and Its Potential Role in Circadian Entrainment: A Nod towards Chrononutrition?

Melatonin regulates endoplasmic reticulum stress in diverse pathophysiological contexts: A comprehensive mechanistic review

Preeclampsia: A comprehensive review

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