Melatonin Level Variations with Different Behavioural Risk Factors in Obese Female Patients

Malazonia, A; Zerekidze, T; Giorgadze, Elen; Chkheidze, N; Asatiani, Ketevan

doi:10.3889/oamjms.2017.063

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…The serum level of melatonin in obese subjects seems to have two different phases. In the early stage of obesity, the serum melatonin is elevated, and this elevation is considered as a protective mechanism to fight high free radicals in obesity [ 189 ]. However, in the case of extreme obesity, the melatonin level is significantly reduced compared to the controls [ 190 ].…”

Section: The Outcomes Of Covid-19 Are Potentially Linked To Melatomentioning

confidence: 99%

Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19

Tan¹,

Hardeland

2020

Molecules

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Fighting infectious diseases, particularly viral infections, is a demanding task for human health. Targeting the pathogens or targeting the host are different strategies, but with an identical purpose, i.e., to curb the pathogen’s spreading and cure the illness. It appears that targeting a host to increase tolerance against pathogens can be of substantial advantage and is a strategy used in evolution. Practically, it has a broader protective spectrum than that of only targeting the specific pathogens, which differ in terms of susceptibility. Methods for host targeting applied in one pandemic can even be effective for upcoming pandemics with different pathogens. This is even more urgent if we consider the possible concomitance of two respiratory diseases with potential multi-organ afflictions such as Coronavirus disease 2019 (COVID-19) and seasonal flu. Melatonin is a molecule that can enhance the host’s tolerance against pathogen invasions. Due to its antioxidant, anti-inflammatory, and immunoregulatory activities, melatonin has the capacity to reduce the severity and mortality of deadly virus infections including COVID-19. Melatonin is synthesized and functions in mitochondria, which play a critical role in viral infections. Not surprisingly, melatonin synthesis can become a target of viral strategies that manipulate the mitochondrial status. For example, a viral infection can switch energy metabolism from respiration to widely anaerobic glycolysis even if plenty of oxygen is available (the Warburg effect) when the host cell cannot generate acetyl-coenzyme A, a metabolite required for melatonin biosynthesis. Under some conditions, including aging, gender, predisposed health conditions, already compromised mitochondria, when exposed to further viral challenges, lose their capacity for producing sufficient amounts of melatonin. This leads to a reduced support of mitochondrial functions and makes these individuals more vulnerable to infectious diseases. Thus, the maintenance of mitochondrial function by melatonin supplementation can be expected to generate beneficial effects on the outcome of viral infectious diseases, particularly COVID-19.

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Section: The Outcomes Of Covid-19 Are Potentially Linked To Melatomentioning

confidence: 99%

Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19

Tan¹,

Hardeland

2020

Molecules

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“…67 Therefore, at ZT15 (at night) the highest peak of melatonin secretion may have already occurred in females, whereas in males this process is occurring in that point of time. Moreover, hypersecretion during metabolic syndrome, due to an increase of the sympathetic activity in the SCN, 68 could explain the higher levels of this hormone showed by CAF-fed females compared to STD-fed females.…”

Section: Discussionmentioning

confidence: 99%

Administration time effect of dietary proanthocyanidins on the metabolome of Fischer 344 rats is sex- and diet-dependent

et al. 2023

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“…In the scientific literature, studies can be found not only concerning the relation between sleep duration and the amount of adipose tissue, but also clarifying the relationship of the mechanism. Too short sleep results in a lower level of leptin and simultaneous growth in ghrelin level [ 8 , 33 , 34 , 35 , 36 ]. Consequently, this may lead to obesity and the development of metabolic disorders [ 9 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

“…Sleep shortening decreases peripheral sensitivity to insulin and promotes hunger. Maintaining a lower activity of insulin and increased intake of calories may result in body weight growth and, consequently, the development of obesity [ 8 , 36 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

Associations between Sleep Duration and Anthropometric Indices of Adiposity in Female University Students

Borowska-Strugińska

Suder

Kliś

et al. 2022

IJERPH

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Objectives: To examine associations between sleep duration as well as time of going to sleep and anthropometric indices related to the amount and distribution of adiposity. Material: A total of 969 female university students, aged 19–24 years. Methods: Participants self-reported their sleep duration. Body weight, height, and waist circumference were measured. BMI, WHR and WHtR were calculated. Statistical analyses of results involved logistic regression models. Socioeconomic status and level of stress were added as covariates. Results: In 15% of the sample, sleep was too short (<6 h), and 10% slept too long (>8 h). Compared to women who followed the recommended sleep duration, among short sleepers, both underweight and overweight were more frequent, while long sleepers were more likely to be overweight. A higher prevalence of abdominal obesity and increased risk of metabolic syndrome were observed in both short and long sleepers than in recommended sleepers. Irregular sleep times were connected with higher OR, both for BMI < 18.5 and BMI > 25, for WC > 80, and WHtR below 0.4 and above 0.5. Irregular sleep times also led to an increased risk of metabolic diseases prevalence. Conclusions: Both too long and too short sleep increases the risk of overweight, obesity and abdominal obesity and, as a consequence, the risk of metabolic syndrome in young women.

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Melatonin Level Variations with Different Behavioural Risk Factors in Obese Female Patients

Cited by 5 publications

References 12 publications

Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19

Targeting Host Defense System and Rescuing Compromised Mitochondria to Increase Tolerance against Pathogens by Melatonin May Impact Outcome of Deadly Virus Infection Pertinent to COVID-19

Administration time effect of dietary proanthocyanidins on the metabolome of Fischer 344 rats is sex- and diet-dependent

Associations between Sleep Duration and Anthropometric Indices of Adiposity in Female University Students

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