Melatonin: is it an effective antioxidant for pulmonary contusion?

Özdinç, Şerife; Öz, Gürhan; Özdemir, Çiğdem; Kılıç, İbrahim; Karakaya, Zeynep; Bal, Ahmet; Köken, Tülay; Solak, Okan

doi:10.1016/j.jss.2016.05.020

Cited by 17 publications

(10 citation statements)

References 33 publications

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“…Annually, ~2 million days in ICU and 75,000 deaths occur in the USA due to ARDS (74). The 'Berlin definition' was developed in 2012 based on the clinical standards for ALI/ARDS (75). Therefore, preventing ARDS and its complications is an urgent clinical problem for doctors.…”

Section: Mt and Alimentioning

confidence: 99%

“…A high number of clinical and experimental studies were dedicated to prevention and diagnosis in order to improve the prognosis of ARDS. Ozdinc et al (75) reported that MT improved the histopathology of pulmonary contusion and distant organs, including the liver and kidney, by diminishing oxidative stress, including decreasing the levels of ROS, MDA and total antioxidant capacity. Moreover, their findings demonstrated that MT has a significant antioxidant effect on contused lungs within 24 h. Additionally, MT inhibited neutrophil movement and adhesion, and decreased edema and neutrophil infiltration in an experimental model of rat lung injury.…”

Section: Mt and Alimentioning

confidence: 99%

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Effects of melatonin on protecting against lung injury (Review)

Wang

Gao

2021

Exp Ther Med

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Melatonin (MT; N-acetyl-5-methoxy-tryptamine), which has multiple effects and roles, is secreted from the pineal gland at night according to the daily rhythm. In addition to circadian regulation, MT has anti-inflammatory, antioxidant and anticancer functions. Recent studies postulated that MT serves a critical role in apoptosis, anti-ischemic reperfusion injury and anti-proliferative effects on various cells. The current review reported on the underlying mechanism behind the protective effect of MT on lung diseases, such as acute lung injury, acute respiratory distress syndrome, chronic obstructive pulmonary disease, lung ischemia-reperfusion injury, sepsis-induced lung injury and ventilator-induced lung injury. MT is considered an adjuvant with therapeutic drugs for preventing inflammation and is responsible for regulating patient sleep cycles in the intensive care unit. The current review described the anti-inflammatory and antioxidant efficiency of MT with a focus on the molecular mechanisms of action in various lung injuries.

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Section: Mt and Alimentioning

confidence: 99%

Section: Mt and Alimentioning

confidence: 99%

Effects of melatonin on protecting against lung injury (Review)

Wang

Gao

2021

Exp Ther Med

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“…[2829] With regard to the extraordinary high antioxidant effect of melatonin, it has been hypothesized that administration of melatonin may be protective against this kind of injury. [303132] Gitto et al . showed that the administration of melatonin in mechanically ventilated newborns reduced the proinflammatory cytokines and improved the clinical outcome.…”

Section: Discussionmentioning

confidence: 99%

Melatonin supplementation may improve the outcome of patients with hemorrhagic stroke in the intensive care unit

et al. 2017

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Objective:Although mechanical ventilation is frequently a life-saving therapy, its use can result in unwanted side effects. It has been well documented that the choice of sedating agent may influence the duration of mechanical ventilation. Melatonin is a sedative and analgesic agent without any respiratory depressant effect which makes it an attractive adjuvant for sedation in the intubated patients. The aim of this study is to evaluate the effect of melatonin on the duration of mechanical ventilation in patients with hemorrhagic stroke.Methods:Forty adult intubated patients with hemorrhagic stroke, who were admitted to the Intensive Care Unit (ICU) within 24 h of onset, were enrolled in this randomized double-blind study. Subjects in the melatonin group received 30 mg of melatonin every night throughout the nasogastric tube. Length of ICU stay, mortality, and duration of mechanical ventilation were recorded for all patients.Findings:The duration of mechanical ventilation and length of ICU stay were shorter in patients who received melatonin in comparison with the control group, and this difference was statistically significant for the length of ICU stay and marginally significant for the duration of mechanical ventilation. Although not statistically significant, the mortality rate of the control group was 30%, almost double that of the study group (15%).Conclusion:Melatonin possesses hypnotic, analgesic, anti-inflammatory, and anti-oxidative properties that distinguish it as an attractive adjuvant in patients under mechanical ventilation. In conclusion, the administration of melatonin may facilitate the weaning process through decreasing the consumption of sedatives with respiratory depressant properties as well as preventing ventilator-associated lung injury.

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“…It was shown that melatonin improved the histopathology of pulmonary contusion and distant organs. Ozdinc et al [69] found that in rats treated with melatonin, histopathological changes resulting from pulmonary contusion were less severe than in non-treated animals. The authors suggested that this is the effect of the antioxidant properties of the neurohormone [69].…”

Section: Protective Role Of Melatonin In Lung Diseasesmentioning

confidence: 99%

Melatonin as a Potential Adjuvant Treatment for COVID-19 beyond Sleep Disorders

Wichniak

Kania

Siemiński

et al. 2021

IJMS

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Melatonin is registered to treat circadian rhythm sleep–wake disorders and insomnia in patients aged 55 years and over. The essential role of the circadian sleep rhythm in the deterioration of sleep quality during COVID-19 confinement and the lack of an adverse effect of melatonin on respiratory drive indicate that melatonin has the potential to be a recommended treatment for sleep disturbances related to COVID-19. This review article describes the effects of melatonin additional to its sleep-related effects, which make this drug an attractive therapeutic option for treating patients with COVID-19. The preclinical data suggest that melatonin may inhibit COVID-19 progression. It may lower the risk of the entrance of the SARS-CoV-2 virus into cells, reduce uncontrolled hyper-inflammation and the activation of immune cells, limit the damage of tissues and multiorgan failure due to the action of free radicals, and reduce ventilator-induced lung injury and the risk of disability resulting from fibrotic changes within the lungs. Melatonin may also increase the efficacy of COVID-19 vaccination. The high safety profile of melatonin and its potential anti-SARS-CoV-2 effects make this molecule a preferable drug for treating sleep disturbances in COVID-19 patients. However, randomized clinical trials are needed to verify the clinical usefulness of melatonin in the treatment of COVID-19.

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Melatonin: is it an effective antioxidant for pulmonary contusion?

Cited by 17 publications

References 33 publications

Effects of melatonin on protecting against lung injury (Review)

Effects of melatonin on protecting against lung injury (Review)

Melatonin supplementation may improve the outcome of patients with hemorrhagic stroke in the intensive care unit

Melatonin as a Potential Adjuvant Treatment for COVID-19 beyond Sleep Disorders

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