Melatonin inhibits Arg–vasopressin release via MT2 receptor in the suprachiasmatic nucleus-slice culture of rats

Isobe, Yoshiaki; Torii, Takako; Nishino, Hitoo

doi:10.1016/s0006-8993(00)03139-5

Cited by 20 publications

(12 citation statements)

References 22 publications

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“…However, whether melatonin is able to suppress pituitary-adrenal activity in a similarly direct manner, i.e. independent from sleep, is presently unclear as are the pineal-hypothalamic links that, perhaps via an action on releasing factors such as CRH and vasopressin, mediate such inhibition (32,41,42). Also, we emphasize here that a pharmacological dose of melatonin was used; this dose induced clearly supraphysiological blood concentrations and, thus, precludes any speculations concerning the physiological role of endogenous melatonin for pituitary-adrenal function and sleep.…”

Section: Discussionmentioning

confidence: 99%

Melatonin Acutely Improves the Neuroendocrine Architecture of Sleep in Blind Individuals

Fischer

Smolnik

Herms³

et al. 2003

The Journal of Clinical Endocrinology & Metabolism

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In blind individuals, the absence of light cues results in disturbances of sleep and sleep-related neuroendocrine patterns. The Zeitgeber influence of light on the timing of sleep is assumed to be mediated by melatonin, a hormone of the pineal gland, whose secretion is inhibited by light and enhanced during darkness. Here, we investigated whether a single administration of melatonin improves sleep and associated neuroendocrine patterns in blind individuals. In a double-blind crossover study, 12 totally blind subjects received 5 mg melatonin and placebo orally 1 h before bedtime starting at 2300 h. The dose used enhanced blood melatonin concentrations to clearly supraphysiological levels. Melatonin increased total sleep time and sleep efficiency (P < 0.05, respectively) and reduced time awake (P < 0.05). The increment in total sleep time was primarily due to an increase in stage 2 sleep (P < 0.01) and a slight increase in rapid eye movement sleep (P < 0.06). Most important, melatonin normalized in parallel the temporal pattern of ACTH and cortisol plasma concentration. While after placebo, ACTH and cortisol levels did not differ between early and late sleep, melatonin induced the typical suppression of pituitary-adrenal activity during early sleep and a distinct rise during late sleep (P < 0.01, respectively). Cortisol nadir values were also decreased after melatonin (P < 0.05). We conclude from these data that in totally blind individuals the single administration of a clearly pharmacological dose of melatonin can improve sleep function by synchronizing in time the inhibition of pituitary-adrenal activity with central nervous sleep processes.

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Section: Discussionmentioning

confidence: 99%

Melatonin Acutely Improves the Neuroendocrine Architecture of Sleep in Blind Individuals

Fischer

Smolnik

Herms³

et al. 2003

The Journal of Clinical Endocrinology & Metabolism

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“…The PT is an endocrine structure characterized by a very high density of MT 1 receptors in all mammals except humans. The MT 2 receptor is present in the retina and possibly in the brain and SCN as well Isobe et al, 2001). In the SCN, MT 1 receptors would mediate the inhibitory effect on electrical activity, whereas the MT 2 receptor would mediate the phase-shifting effect of MEL.…”

Section: Sites and Mechanisms Of Action Of Melatoninmentioning

confidence: 99%

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

2003

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“…The possible mechanism by which melatonin can modify the vasopressinergic and oxytocinergic neurones activity includes specific G protein-coupled membrane receptors, called MT 1 and MT 2 , activation of which inhibits the synthesis of cAMP [21,24]. These receptors are situated mainly in the pars tuberalis of the pituitary [25] and in the hypothalamic suprachiasmatic (SCN) [15,[26][27][28] as well as magnocellular SON and PVN nuclei [29]. It has been found that AVP-containing cells in the SCN express both MT 1 [27] and MT 2 [28] melatonin receptors and melatonin inhibits AVP release from cultured SCN neurones [15,28].…”

Section: Discussionmentioning

confidence: 99%

“…These receptors are situated mainly in the pars tuberalis of the pituitary [25] and in the hypothalamic suprachiasmatic (SCN) [15,[26][27][28] as well as magnocellular SON and PVN nuclei [29]. It has been found that AVP-containing cells in the SCN express both MT 1 [27] and MT 2 [28] melatonin receptors and melatonin inhibits AVP release from cultured SCN neurones [15,28]. Moreover, it has been found that the cAMP-dependent pathways are involved in an increase in AVP gene expression in the SCN [30].…”

Section: Discussionmentioning

confidence: 99%

Pobudzane stosowaniem forskoliny uwalnianie wazopresyny i oksytocyny z układu podwzgórze–część nerwowa przysadki szczura in vitro jest hamowane przez melatoninę

Roszczyk¹,

Juszczak²

2014

Endokrynologia Polska

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Introduction: Previous in vivo and in vitro studies have shown that melatonin changes vasopressin (AVP) and oxytocin (OT) secretion from the rat neurohypophysis. Additionally, melatonin is known to inhibit the forskolin-induced (forskolin is a strong adenylyl cyclase -AC activator) increase in cAMP accumulation in the rat pituitary. To determine whether the possible response of vasopressinergic and/or oxytocinergic neurones to melatonin could be mediated through a cAMP-dependent mechanism, the effect of different concentrations of melatonin (i.e. 10

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Melatonin inhibits Arg–vasopressin release via MT2 receptor in the suprachiasmatic nucleus-slice culture of rats

Cited by 20 publications

References 22 publications

Melatonin Acutely Improves the Neuroendocrine Architecture of Sleep in Blind Individuals

Melatonin Acutely Improves the Neuroendocrine Architecture of Sleep in Blind Individuals

Generation of the Melatonin Endocrine Message in Mammals: A Review of the Complex Regulation of Melatonin Synthesis by Norepinephrine, Peptides, and Other Pineal Transmitters

Pobudzane stosowaniem forskoliny uwalnianie wazopresyny i oksytocyny z układu podwzgórze–część nerwowa przysadki szczura in vitro jest hamowane przez melatoninę

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