Melatonin induces hypertrophy of brown adipose tissue in Spermophilus tridecemlineatus

Sinnamon, W.B.; Pivorun, Edward B.

doi:10.1016/0011-2240(81)90129-2

Cited by 29 publications

(20 citation statements)

References 10 publications

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“…Thus, melatonin has been shown to induce hypertrophy of brown adipose tissue (Sinnamon & Pivorum, 1981), to be the mediator of the seasonal variations in the brown adipose tissue cyto¬ chrome oxidase activity and mitochondrial proteins (Heldmaier et al 1981), and to enhance the thermotrophic capacity of brown adipose tissue (Viswanathan et al 1986). A pineal influence on body weight related to the energy metabolism and thyroid function has also been found (Bartness & Wade, 1984).…”

Section: Discussionmentioning

confidence: 95%

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Melatonin specifically stimulates type-II thyroxine 5′-deiodination in brown adipose tissue of Syrian hamsters

Puig-Domingo

Guerrero

Menéndez-Peláez

et al. 1989

Journal of Endocrinology

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The response of type-II thyroxine 5'-deiodinase (5'-DII) to melatonin treatment was studied in the Syrian hamster. Male hamsters were treated for 15 days with a s.c. pellet containing melatonin, and 5'-DII activity in brown adipose tissue, anterior pituitary gland, Harderian gland and pineal gland was measured using a radioenzymatic technique. Melatonin-treated animals exhibited enhanced 5'-DII activity restricted to brown adipose tissue; the increase was threefold above the values measured in the control group. Serum concentrations of thyroid hormones were unaffected by melatonin treatment. We conclude that the stimulatory effect of melatonin on type-II thyroxine 5'-deiodination is specifically directed to the isoenzyme located in brown adipose tissue and is not accompanied by changes in serum thyroid hormones.

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Section: Discussionmentioning

confidence: 95%

“…Melatonin has been found to act on brown adipose tissue as a growth promoter (Sinnamon & Pivorum, 1981) and as an enhancer of cytochrome oxidase activity (Heldmaier, Steinlechner, Rafael & Vsiansky, 1981). Brown adipose tissue seems to play an import¬ ant role in the maintenance of an adequate thermoregulatory response to cold.…”

Section: Introductionmentioning

confidence: 99%

Melatonin specifically stimulates type-II thyroxine 5′-deiodination in brown adipose tissue of Syrian hamsters

Puig-Domingo

Guerrero

Menéndez-Peláez

et al. 1989

Journal of Endocrinology

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“…These methods are not limited to use of β 3 ‐adrenergic receptor agonists. Other substances including melatonin have the potential for modulating BAT activity in several small mammals (7,64,65). The readily manipulated physiology of BAT seems to provide a suitable target for novel drug development for the purpose of combating human obesity.…”

Section: Brown Adipose Tissue and Obesitymentioning

confidence: 99%

“…Interestingly, melatonin, a tryptophan derivative, has been found to have the ability to increase the capacity of non‐shivering thermogenesis of BAT in small mammals (7). This molecule is produced endogenously by the pineal gland as well as by other organs and tissues (8,9).…”

Section: Introductionmentioning

confidence: 99%

Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity

Tan¹,

Manchester²,

et al. 2011

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A worldwide increase in the incidence of obesity indicates the unsuccessful battle against this disorder. Obesity and the associated health problems urgently require effective strategies of treatment. The new discovery that a substantial amount of functional brown adipose tissue (BAT) is retained in adult humans provides a potential target for treatment of human obesity. BAT is active metabolically and disposes of extra energy via generation of heat through uncoupling oxidative phosphorylation in mitochondria. The physiology of BAT is readily regulated by melatonin, which not only increases recruitment of brown adipocytes but also elevates their metabolic activity in mammals. It is speculated that the hypertrophic effect and functional activation of BAT induced by melatonin may likely apply to the human. Thus, melatonin, a naturally occurring substance with no reported toxicity, may serve as a novel approach for treatment of obesity. Conversely, because of the availability of artificial light sources, excessive light exposure after darkness onset in modern societies should be considered a potential contributory factor to human obesity as light at night dramatically reduces endogenous melatonin production. In the current article, the potential associations of melatonin, BAT, obesity and the medical implications are discussed.

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“…For its amphiphilicity, melatonin is readily released into the bloodstream and cerebrospinal fluid, presenting immediate (nonreceptor and receptor‐mediated) and prospective (chronobiotic, seasonal, and transgenerational) effects that are dependent on its different ways of action . Melatonin has been shown to regulate BAT, acting as a recruiter and increasing its thermogenic capacity . Despite its regulatory role in other metabolic active tissues and the evidences of its interaction with BAT, little is known about its role in the metabolic thermogenic pathway either in its daily regulation or after acute challenges.…”

Section: Introductionmentioning

confidence: 99%

Melatonin multiple effects on brown adipose tissue molecular machinery

Souza

Gallo

Camargo

et al. 2019

Journal of Pineal Research

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Brown adipose tissue (BAT) influences energy balance through nonshivering thermogenesis, and its metabolism daily and seasonal variations are regulated by melatonin through partially known mechanisms. We evaluated the role of melatonin in BAT molecular machinery of male Control, pinealectomized (PINX), and melatonin‐treated pinealectomized (PINX/Mel) adult rats. BAT was collected either every 3 hours over 24 hours or after cold or high‐fat diet (HFD) acute exposure. HFD PINX animals presented decreased Dio2 expression, while HFD PINX/Mel animals showed increased Dio2, Ucp1, and Cidea expression. Cold‐exposed PINX rats showed decreased Dio2 and Lhs expression, and melatonin treatment augmented Adrβ3, Dio2, Ucp1, and Cidea expression. Daily profiles analyses showed altered Dio2, Lhs, Ucp1, Pgc1α, and Cidea gene and UCP1 protein expression in PINX animals, leading to altered rhythmicity under sub‐thermoneutral conditions, which was partially restored by melatonin treatment. The same was observed for mitochondrial complexes I, II, and IV protein expression and enzyme activity. Melatonin absence seems to impair BAT responses to metabolic challenges, and melatonin replacement reverses this effect, with additional increase in the expression of crucial genes, suggesting that melatonin plays an important role in several key points of the thermogenic activation pathway, influencing both the rhythmic profile of the tissue and its ability to respond to metabolic challenges, which is crucial for the organism homeostasis.

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Melatonin induces hypertrophy of brown adipose tissue in Spermophilus tridecemlineatus

Cited by 29 publications

References 10 publications

Melatonin specifically stimulates type-II thyroxine 5′-deiodination in brown adipose tissue of Syrian hamsters

Melatonin specifically stimulates type-II thyroxine 5′-deiodination in brown adipose tissue of Syrian hamsters

Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity

Melatonin multiple effects on brown adipose tissue molecular machinery

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