Melatonin in the multi‐oscillatory mammalian circadian world

Pévet, Paul; Agez, Laurence; Bothorel, Béatrice; Saboureau, Michel; Guilhot, François; Laurent, Virginie; Masson‐Pévet, Mireille

doi:10.1080/07420520500482074

Cited by 84 publications

(57 citation statements)

References 54 publications

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“…Its secretion occurs only at night in both diurnal and nocturnal mammals (65). Circadian rhythm regulation via SCN, depends on the regularly secretion of pineal melatonin and existence of healthy melatonin receptors in SCN as well (66). In healthy subjects, DimLight Melatonin Onset (DLMO) occurs 1-2 h before sleep onset.…”

Section: Melatonin and Melatonin Agonistsmentioning

confidence: 99%

Psychotropic medications affecting biological rhythm

Oral¹,

Özcan²,

Güleç³

et al. 2011

JMOOD

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Biyolojik ritmi etkileyen psikotrop ilaçlarBirçok canlı organizmada, omurgalı ve memeli canlıda olduğu gibi insanda da biyolojik işlevler çeşitli aralıklarla salınan ritimlerle yürür. Sirkadyen, ultradien ve infradian ya da daha uzun aralıklarla salınan iç ritimlerimiz kendi iç düzenlerini her şartta devam ettiren, bağımsız biyolojik organizasyonlardır. Biyolojik olarak kendiliğinden işleyen, istikrarlı bir yol varsa da, gerek psikiyatrik hastalıklar ve gerekse de psikotrop ilaçlar bu iç ritimleri değiştirebilir. Psikotrop ilaçlar, etki düzeneklerindeki nörotransmmitter ya da nöromediatörler vasıtasıyla doğrudan veya daha uzun vadede hormonal ya da genetik değişikliklere neden olarak da biyolojik ritimler üzerine etkili olabilir. Biyolojik ritim düzensizliklerinin duygudurum bozuklukları açısından hem neden hem de sonuç olarak önemine dikkat çeken birçok çalışma vardır. Duygudurum bozukluklarının takip ve tedavisinde psikofarmakolojik ajanların biyolojik ritimlere olan muhtemel etkisi de değerlendirilmesi önemlidir.

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Section: Melatonin and Melatonin Agonistsmentioning

confidence: 99%

Psychotropic medications affecting biological rhythm

Oral¹,

Özcan²,

Güleç³

et al. 2011

JMOOD

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“…Melatonin is a hormone secreted by the pineal gland, the rhythm of which is controlled and generated by the intrinsic circadian pacemaker located in the suprachiasmatic nuclei (SCN) of the hypothalamus (Pévet et al, 2006). The primary function of the melatonin profile in mammals is to convey information concerning daylength for organizing daylengthdependent seasonal functions.…”

Section: Introductionmentioning

confidence: 99%

Evening Alcohol Suppresses Salivary Melatonin in Young Adults

Rupp

Acebo

Carskadon

2007

Chronobiology International

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The study objective was to determine the acute effects of a moderate evening dose of alcohol on salivary melatonin levels in humans with stable prior sleep-wake histories and in a controlled environment. Twenty-nine adults (nine males) ages 21 to 25 (M ¼ 22.6, SD ¼ 1.2) yrs adhered to a 10-day at-home stabilized sleep schedule followed by three in-lab adaptation, placebo, and alcohol (order counterbalanced) study nights. Alcohol (vodka: 0.54 g/kg for men and 0.49 g/kg for women) or placebo beverage was consumed over 30 min, ending 1 h before stabilized bedtime. At 140 and 190 min after alcohol administration, melatonin level was reduced by 15% and 19%, respectively, in comparison to placebo. The findings indicate that a moderate dose of alcohol in the evening suppressed melatonin in young adults.

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“…Light information is received by distinct retinal photoreceptors, sent to the suprachiasmatic nucleus (SCN) and then projected by efferent connections to the pineal gland; the pineal comparably synthesizes and secretes melatonin during the dark period (scotophase) in diurnal and nocturnal mammals. The circulating melatonin rhythm is suggested to play a major regulating role in the mammalian photoentrainment system (Pévet et al, 2006;Pandi-Perumal et al, 2008;Zawilska et al, 2009). The mammalian retina presents two distinctive classes of photoreceptors: image-forming photoreceptors (IFPRs) and non-image-forming photoreceptors (NIFPRs).…”

Section: Introductionmentioning

confidence: 99%

Photoentrainment in blind and sighted rodent species: responses to photophase light with different wavelengths

Zubidat

Nelson

Haim

2010

Journal of Experimental Biology

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SUMMARYOur study examined the impact of daylight (photophase) wavelength on the photoentrainment sensitivity of two species with vastly different visual systems. Social voles (Microtus socialis) and 'blind' mole rats (Spalax ehrenbergi) were exposed to shortwavelength (479nm) or long-wavelength (697nm) light at an intensity of 293Wcm -2 . Rhythms of urine production, urinary 6-sulfatoxymelatonin (6-SMT), urinary metabolites of adrenaline and cortisol, and oxygen consumption (VO 2 ) were used as markers for the sensitivity of the photoentrainment system. Significant 24-h rhythms were detected in all variables for both species under short-wavelength light, whereas ultradian rhythms of 12-or 8-h were detected under long-wavelength light. Wavelength inversely affected 6-SMT levels in M. socialis (negative correlation) and S. ehrenbergi (positive correlation). Increased levels of stress hormone metabolites were detected in M. socialis under the long-wavelength light whereas, in S. ehrenbergi elevated levels were secreted under short-wavelength light. Long-wavelength light increased VO 2 in M. socialis and decreased it in S. ehrenbergi; short-wavelength light elicited the opposite effects. Our results indicate that photophase wavelength is an integral light property for modulating photoperiodic responses in mammals, including visually challenged species. Finally, the spectral-induced differential responses between the two species potentially represent adaptive physiological flexibility in species with contrasting visual and habitat challenges. Supplementary material available online at

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Melatonin in the multi‐oscillatory mammalian circadian world

Cited by 84 publications

References 54 publications

Psychotropic medications affecting biological rhythm

Psychotropic medications affecting biological rhythm

Evening Alcohol Suppresses Salivary Melatonin in Young Adults

Photoentrainment in blind and sighted rodent species: responses to photophase light with different wavelengths

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