Melatonin in serum and urine in patients with idiopathic pain syndromes

Exacerbated mechanical allodynia in rats with depression-like behavior

“…Of note is that those rats with an incorrect cannula placement did not show improvement in either immobility score or mechanical allodynia, suggesting a selective effect of melatonin within ACC. This behavioral data is also consistent with a low plasma melatonin level in WKY rats and in patients suffering from abdominal pain, idiopathic pain, neuropathic pain, or cluster headache (Waldenlind et al, 1987;Almay et al, 1987;Roberts-Thompson et al, 1988;von Knorring, Ekselius, 1994;Leone et al, 1995). It should be noted that the role of a specific MT receptor subtype was not examined in this study, because luzindole (MT2 > MT1) is not a highly selective antagonist for an MT receptor subtype.…”

Reproducibility of the circadian rhythms of serum cortisol and melatonin in healthy subjects: a study of three different 24-h cycles over six weeks

“…Conversely, melatonin, which peaks at night (hormone of the darkness), is implicated in depression and jet lag (Fevre-Montange et al, 1981), among other disorders. Indeed, most studies have reported that melatonin levels were found to be decreased in major depression (Claustrat et al, 1984;Beck-Friis et al, 1985;Wetterberg, 1985;Brown et al, 1985;Almay et al, 1987). However, in jet lag and with a rapid change of time zone, melatonin is no more in phase along with the environment, it takes several days for the external factors to shift the phase of the body clock from one time zone to another new zone.…”

Melatonin therapy in fibromyalgia

“…Finally, as altered muscle physiology may participate in the pathophysiology of FMS, the actions of melatonin in terms of its ability to enhance mitochondrial bioenergetics [9–11] may be pertinent to its beneficial effects in these patients. While reduced levels of melatonin have been reported in FMS women [12], alterations in its circadian rhythm seem to be not a primary cause of FMS.…”