Melatonin in Human Serum: Progress in Screening Investigation and Clinic

Birau, N.

doi:10.1016/b978-0-08-026400-4.50042-6

Cited by 25 publications

(13 citation statements)

References 11 publications

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“…Indeed, several laboratories have reported that male Sprague-Dawley rats develop hypertension [12][13][14][15][16][17][18][19][20] following pinealectomy. Pinealectomy-induced hyperten sion can be prevented by oxypertine, a cen trally acting adrenergic blocking agent with a 5-methoxyindole structure resembling mela tonin [14], In addition, melatonin was shown to reduce essential hypertension in humans [1] and spontaneous hypertension in rats [4], Furthermore, it was found that melatonin concentration in the nocturnal serum of spon taneously hypertensive rats was elevated at the prehypertensive stage [3], while it was decreased after the development of hyperten sion when compared with age-matched normotensive Wistar-Kyoto rats [3], These ob servations support the possibility that the pi neal gland may play a role in cardiovascular control and that an abnormality in melatonin secretion might play a role in the pathogenesis of hypertension. Hall and Quay [21], how ever.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence has accumulated to indicate that melatonin, one of the pineal hormones, acts on the brain to regulate blood pressure in mammals [1][2][3][4]. For example, the hypoten sive effect of melatonin has been observed in patients with essential hypertension [2] or in vates blood pressure and reduces heart rate when injected into the cerebral ventricles [6,7], These observations suggest the possibility that the hypotensive effects of melatonin may be related to the endogenous release of brain serotonin.…”

Section: Introductionmentioning

confidence: 99%

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Melatonin Decreases Brain Serotonin Release, Arterial Pressure and Heart Rate in Rats

1993

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The effects of intravenous administration of melatonin (30–60 mg/kg) or vehicle (10% alcohol) on arterial pressure, heart rate, blood gases or brain serotonin release were assessed in rats under urethane anesthesia. Administration of melatonin, but not the vehicle, produced a dose-related fall in mean arterial pressure, heart rate, or serotonin release in both the corpus striatum and the hypothalamus. Melatonin treatment had an insignificant effect on either P_aCO₂, P_aO₂ or pH. In addition, the melatonin-induced depressor responses were abolished by pretreatment with spinal transection, whereas melatonin-induced bradycardia was abolished by pretreatment with bilateral vagotomy. These results suggest that melatonin decreases brain serotonin release and results in sympathetic inhibition or parasympathetic stimulation which leads to hypotension and bradycardia in rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Melatonin Decreases Brain Serotonin Release, Arterial Pressure and Heart Rate in Rats

1993

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“…Only a few investigators have attempted to characterize plasma melatonin patterns throughout the normal menstrual cycle (14)(15)(16)(17)(18), and wide discrepancies exist among the findings in these reports. In most of these studies plasma melatonin concentrations were measured only a few times during the 24-h light-dark cycle or in only small numbers of women.…”

mentioning

confidence: 99%

The Circadian Rhythm of Plasma Melatonin During the Normal Menstrual Cycle and in Amenorrheic Women*

Brzezinski¹,

Lynch²,

Seibel³

et al. 1988

The Journal of Clinical Endocrinology & Metabolism

167

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Plasma melatonin, PRL, and LH levels were measured in samples collected every 2 h for 24 h from 14 normally cycling women during the early follicular, periovulatory, and luteal phases of their menstrual cycles. Plasma melatonin levels also were measured in samples collected at the same interval from 7 patients with hypothalamic amenorrhea. A distinct daily rhythm in plasma melatonin was evident in all subjects, with peaks occurring around 0300 h. Each woman's rhythm was remarkably consistent throughout the menstrual cycle (in terms of the phase, amplitude, and total melatonin secreted). Plasma PRL levels also exhibited daily rhythms which did not change during the menstrual cycle; the nocturnal peak plasma PRL level tended to occur 1-2 h after that for melatonin. Among the amenorrheic women, both daytime and nighttime melatonin levels were significantly higher (P less than 0.005) than in the normal women. Their plasma PRL levels were similar to those in the normal women. We conclude that, as for PRL, the circadian rhythm of melatonin secretion does not change significantly during the normal menstrual cycle. The elevated plasma melatonin levels in women with hypothalamic amenorrhea suggest that the hormone may be involved in the neuroendocrine pathology underlying this disorder.

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“…8-MOP has a similar effect in the rat [12,15] as well as in the human [11]. Since these drugs have a strong structural resem blance and have equipotent effects on differ ent cellular models, it seems very likely that the 8-MOP-induced increase in plasma Mel levels is also due to inhibition of Mel hydrox ylation.…”

Section: Discussionmentioning

confidence: 82%

“…8-Methoxypsoralen (8-MOP) is known to induce an increase in plasma Mel levels in the human [11] and in the rat [12]. Despite this increase in circulating Mel concentrations, no change in the pineal N-acetyltransferase ac tivity and Mel content were reported [13].…”

Section: Melatoninmentioning

confidence: 99%

5-Methoxypsoralen Inhibits 6-Hydroxylation of Melatonin in the Rat

Mauviard

Raynaud²,

Geoffriau³

et al. 1995

Neurosignals

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Pharmacokinetic studies of exogenous melatonin (100 or 1 µg) administered to 5-methoxypsoralen (MOP)-treated rats, showed that MOP administration induced an increase in the half-life of melatonin from 22 to 67 min. This delayed degradation of melatonin was the consequence of 5-MOP-induced inhibition of the 6-hydroxylation of melatonin. Under in vitro experimental conditions, 5-MOP did not affect melatonin synthesis and release. These results demonstrate that the elevated plasma melatonin concentrations observed in vivo following 5-MOP administration is due to inhibition of the hydroxylation of endogenous melatonin.

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Melatonin in Human Serum: Progress in Screening Investigation and Clinic

Cited by 25 publications

References 11 publications

Melatonin Decreases Brain Serotonin Release, Arterial Pressure and Heart Rate in Rats

Melatonin Decreases Brain Serotonin Release, Arterial Pressure and Heart Rate in Rats

The Circadian Rhythm of Plasma Melatonin During the Normal Menstrual Cycle and in Amenorrheic Women*

5-Methoxypsoralen Inhibits 6-Hydroxylation of Melatonin in the Rat

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