Melatonin in aging women

Gürsoy, Aslı Yarcı; Kiseli, Mine; Çağlar, Gamze Sinem

doi:10.3109/13697137.2015.1052393

Cited by 45 publications

(26 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Circulating melatonin levels decline with age [28,29]. Plasma levels of melatonin are higher at nighttime throughout the life span, although it is the absolute concentrations that decline with age [30,31]. It has been shown that when melatonin is given, it provides neuroprotection [32,33] and improved cognitive function [34].…”

Section: Discussionmentioning

confidence: 99%

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function and Health in Men and Women

Bloomer

2017

ACIM

View full text Add to dashboard Cite

Background: We have previously reported improvements in selected biochemical measures of health, as well as self reported well-being in men and women using the dietary supplement known as CLOCK ® . In this follow up investigation, we evaluated CLOCK ® at two different dosages using a randomized, placebo controlled, cross-over design in men and women with self reported low energy, impaired sleep quality and impaired well-being.Methods: 30 subjects (14 men and 16 women) were randomly assigned in double blind manner to ingest a botanical agent (CLOCK ® , containing Rosmarinus officinalis and Hemerocallis fulva at either 1gram or 1.5grams daily) or a placebo for two week periods with a two week wash out period after each condition assignment. Blood samples were collected pre and post each two week period in an overnight fasted state and analyzed for acetylcholine (ACh), choline, Brain Derived Neurotrophic Factor (BDNF), IGF-1, irisin, melatonin and serotonin. Heart rate and blood pressure were measured, as were subjective measures of well-being. The Leeds Sleep Evaluation Questionnaire was used as a measure of sleep quality and related variables.Results: ACh (22%), choline (19%), BDNF (44%), irisin (23%) and melatonin (8%) all increased significantly from pre to post intervention following intake of CLOCK ® (with a greater increase noted with 1gram vs. 1.5grams) but not placebo. Heart rate and blood pressure were unaffected by treatment (p>0.05). Time effects were noted for all well-being measures (p<0.05), except for anxious, depressed and tense, with improvements noted in all variables from pre to post intervention. When considering both supplement dosages together, improvements of 25% (attentiveness), 21% (alertness), 37% (focus) and 34% (energetic) were observed, with slightly less improvement noted for placebo. Although, not significant, CLOCK ® reduced the feeling of grogginess (25%), lethargy (14%) and sluggishness (18%); whereas there were minimal changes with the placebo. No differences were noted between conditions or across time in measures of sleep or related variables (p>0.05).

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function and Health in Men and Women

Bloomer

2017

ACIM

View full text Add to dashboard Cite

show abstract

“…This is consistent with numerous previous studies on the use of pharmacological melatonin in the treatment of sleep disturbances in elderly men and women [cf. (110)].…”

Section: Melatonin In Reproductive Agingmentioning

confidence: 99%

Melatonin and Female Reproduction: An Expanding Universe

Olcese

2020

Front. Endocrinol.

View full text Add to dashboard Cite

For more than a half century the hormone melatonin has been associated with vertebrate reproduction, particularly in the context of seasonal breeding. This association is due in large measure to the fact that melatonin secretion from the pineal gland into the peripheral circulation is a nocturnal event whose duration is reflective of night length, which of course becomes progressively longer during winter months and correspondingly shorter during the summer months. The nocturnal plasma melatonin signal is conserved in essentially all vertebrates and is accessed not just for reproductive rhythms, but for seasonal cycles of metabolic activities, immune functions, and behavioral expression. A vast literature on melatonin and vertebrate biology has accrued over the past 60 years since melatonin's discovery, including the broad topic of animal reproduction, which is far beyond the scope of this human-focused review. Although modern humans in the industrialized world appear in general to have little remaining reproductive seasonality, the relationships between melatonin and human reproduction continue to attract widespread scientific attention. The purpose of this chapter is to draw attention to some newer developments in the field, especially those with relevance to human fertility and reproductive medicine. As the vast majority of studies have focused on the female reproductive system, a discussion of the potential impact of melatonin on human male fertility will be left for others.

show abstract

“…Furthermore, lower levels of melatonin in postmenopausal women may correlate with depressive symptoms [46]. Thus, melatonin therapy may have a favorable effect on those and related symptoms, such as VMS [47].…”

Section: Circadian Rhythm Disordersmentioning

confidence: 99%

Italian Association of Sleep Medicine (AIMS) position statement and guideline on the treatment of menopausal sleep disorders

et al. 2019

View full text Add to dashboard Cite

Insomnia, vasomotor symptoms (VMS) and depression often co-occur after the menopause, with consequent health problems and reductions in quality of life. The aim of this position statement is to provide evidence-based advice on the management of postmenopausal sleep disorders derived from a systematic review of the literature. The latter yielded results on VMS, insomnia, circadian rhythm disorders, obstructive sleep apnea (OSA) and restless leg syndrome (RLS). Overall, the studies show that menopausal hormone therapy (MHT) improves VMS, insomnia, and mood. Several antidepressants can improve insomnia, either on their own or in association with MHT; these include selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), and mirtazapine. Long-term benefits for postmenopausal insomnia may also be achieved with non-drug strategies such as cognitive behavioral therapy (CBT) and aerobic exercise. Continuous positive airway pressure (CPAP) and mandibular advancement devices (MADs) both reduce blood pressure and cortisol levels in postmenopausal women suffering from OSA. However, the data regarding MHT on postmenopausal restless legs syndrome are conflicting.

show abstract

Melatonin in aging women

Cited by 45 publications

References 66 publications

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function and Health in Men and Women

Impact of the Dietary Supplement CLOCK® on BDNF and Other Biochemical Measures Related to Cognitive Function and Health in Men and Women

Melatonin and Female Reproduction: An Expanding Universe

Italian Association of Sleep Medicine (AIMS) position statement and guideline on the treatment of menopausal sleep disorders

Contact Info

Product

Resources

About