Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia

Castaño, M. Y.; Garrido, María; Rodríguez, Ana B.; Gómez, María Ángeles

doi:10.1177/1099800418811634

Cited by 15 publications

(17 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These findings are similar to previous research that studied women diagnosed with FM, which found that FM patients reported more severe symptoms of depression, anxiety, insomnia and fatigue than controls, which constitute typical bodily and mental symptoms accompanying FM pain [32]. Elevated levels of pain catastrophizing and negative affect have also been previously observed [33][34][35][36].…”

Section: Discussionsupporting

confidence: 90%

The Role of Pain Catastrophizing and Anxiety Levels on Quality of Life in Fibromyalgia Compared with Healthy Women

Grinberg¹,

Meshalhov²,

Adadi³

et al. 2019

Intern Med

View full text Add to dashboard Cite

Patients with fibromyalgia (FM) present with chronic and diffuse musculoskeletal pain, a low pain threshold at specific anatomical points, weakness and fatigue, which eventually lead to reduced physical activity and decreased quality of life. Some studies have indicated a link between FM and personality and mental characteristics, but few have examined differences between women with FM and healthy women. The goals of this research were to investigate these differences, as well as the link between the degree of catastrophizing and coping with the disease among sick women. This comparative and correlative study examined 165 women 75 (46%) with FM and 90 (54%) healthy women. All the subjects filled out a socio-demographic questionnaire, the State and Trait Anxiety Questionnaire, and the Short Form Health Survey (SF-12). In addition, the women diagnosed with FM answered the Pain Catastrophizing Scale and the Fibromyalgia Impact Questionnaire (FIQ). We found that women with FM report high levels of anxiety and low levels of quality of life regarding their disease. It seems that their mental health is linked to their physical status. Interventions to improve mental health in this patient population may also bring enhancement in quality of life.

show abstract

Section: Discussionsupporting

confidence: 90%

The Role of Pain Catastrophizing and Anxiety Levels on Quality of Life in Fibromyalgia Compared with Healthy Women

Grinberg¹,

Meshalhov²,

Adadi³

et al. 2019

Intern Med

View full text Add to dashboard Cite

show abstract

“…According to Vis et al’s systematic review, the limited pharmacological treatment for reduced quality of life or fatigue in sarcoidosis patients are available ( 42 ). However, the use of melatonin can improve PCS in patients with fibromyalgia ( 43 ), delayed sleep phase syndrome ( 44 ), and chronic fatigue ( 45 ), While administration of melatonin cannot improve PCS in women with osteoporosis ( 46 ) and hemodialysis patients ( 47 ). In our study, administration of 3 mg melatonin for three months can improve subjective sleep quality.…”

Section: Discussionmentioning

confidence: 99%

Study of the Effects of Melatonin on Sleep Disorders in Pulmonary Sarcoidosis Patients

et al. 2023

View full text Add to dashboard Cite

Background: The symptoms of pulmonary sarcoidosis may lead to fatigue, excessive daytime sleepiness, poor sleep quality, and a decrease in quality of life in these patients. Objectives: This study was designed to evaluate the effects of oral melatonin on sleep disorders of patients with pulmonary sarcoidosis. Methods: A randomized, single-blinded clinical trial was conducted on patients with pulmonary sarcoidosis. Eligible patients were randomly allocated into melatonin and control groups. Patients in the melatonin group were given 3 mg melatonin one hour before bedtime for three months. Sleep quality, daytime sleepiness, fatigue status, and quality of life were assessed applying General Sleep Disturbance Scale (GSDS), Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Fatigue Assessment Scale (FAS), and the Patient-Reported Outcomes Measurement Information System (PROMIS), respectively, as well as the 12-item Short Form Survey (SF-12) scores at the baseline and three months after treatment. Results: There was a significant change in the GSDS (P < 0.001), PSQI (P < 0.001), ESS (P = 0.002), and FAS (P < 0.001) scores, which were decreased, compared to those of the control group. After intervention¸ global physical health and global mental health raw scores were improved comparing to the control group (P = 0.006, P = 0.02, respectively). The 12-item Short Form Survey evaluation showed that there was a significant difference between the melatonin (3.38 ± 4.61) and control (0.55 ± 7.25) groups in PCS-12 score after three months of therapy (P = 0.02). Conclusions: Our findings showed that supplemental melatonin could significantly improve sleep problems, quality of life, and excessive daytime sleepiness in sarcoidosis patients.

show abstract

“…Furthermore, it has been shown that melatonin is associated with modulation of mood, sexual maturation and body temperature. Also, it is beneficial in periodontology [45]. The interplay between melatonin and ROS is oxidized into N1-acetyl-N2-formyl-5methoxykynuramine (AFMK), which has high antioxidant activity [46].…”

Section: Melatonin; Physiology and Importancementioning

confidence: 99%

Antitumor and Protective Effects of Melatonin: The Potential Roles of MicroRNAs

Ashrafizadeh

Ahmadi

Yaribeygi

et al. 2021

Advances in Experimental Medicine and Biology

View full text Add to dashboard Cite

MicroRNAs are endogenous short non-coding RNAs with approximately 22 nucleotides.The primary function of miRNAs in the negative regulation of target gene expression via mRNA degradation and translation inhibition. During recent years, much attention has been made towards miRNAs' role in different disorders, particularly cancer and compounds with modulatory effects on miRNAs are of interest. Melatonin is one of these compounds which is secreted by the pineal gland. Also, melatonin is present in the leaves, fruits and seeds of plants. Melatonin has several valuable biological activities such as anti-oxidant, anti-inflammation, anti-tumor and anti-ageing activities. This important agent is extensively used to treat different disorders such as cancer, neurodegenerative and cardiovascular disease. This review aims to describe the modulatory effect of melatonin on miRNAs, as novel targets.

show abstract

Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia

Cited by 15 publications

References 30 publications

The Role of Pain Catastrophizing and Anxiety Levels on Quality of Life in Fibromyalgia Compared with Healthy Women

The Role of Pain Catastrophizing and Anxiety Levels on Quality of Life in Fibromyalgia Compared with Healthy Women

Study of the Effects of Melatonin on Sleep Disorders in Pulmonary Sarcoidosis Patients

Antitumor and Protective Effects of Melatonin: The Potential Roles of MicroRNAs

Contact Info

Product

Resources

About