Melatonin improves behavioral parameters and oxidative stress in zebrafish submitted to a leucine-induced MSUD protocol

Duarte, Mariane Bernardo; Medeiros, Bianca Z. de; Lemos, Isabela da Silva; Silva, Guilherme Lodetti da; Alano, Carolina Giassi; Dondossola, Eduardo Ronconi; Torres, Carolina A.; Effting, Pauline Souza; Rico, Eduardo Pacheco; Streck, Emílio L.

doi:10.1007/s11011-023-01220-8

Cited by 1 publication

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“…It has been shown that melatonin is capable of indirectly scavenging free radicals by regulating the activity and expression of other antioxidant systems in both plant and mammals (Bidabadi et al 2020 ; Morvaridzadeh et al 2020 ; Nogués et al 2006 ). In zebrafish, like in other animals, melatonin also maintains the redox balance by regulating the ratio of reduced glutathione to oxidized glutathione (GSH/GSSG), reducing lipid peroxidation, and enhancing the activity and expression of other antioxidant enzymes such as SOD and catalase (Duarte et al 2023 ; Lunkes et al 2021 ; Yan et al 2022 ). Furthermore, melatonin administration alleviated the reduction in catalase, glutathione peroxidase and SOD activity following sleep-deprivation and enhanced GSH/GSSG ratio levels to normal (Alzoubi et al 2016 ).…”

Section: Sleep-modulating Neuropeptides Hormones and Their Connection...mentioning

confidence: 99%

Phylogenetic conservation of the interdependent homeostatic relationship of sleep regulation and redox metabolism

Terzi,

Ngo,

Mourrain

2024

J Comp Physiol B

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Sleep is an essential and evolutionarily conserved process that affects many biological functions that are also strongly regulated by cellular metabolism. The interdependence between sleep homeostasis and redox metabolism, in particular, is such that sleep deprivation causes redox metabolic imbalances in the form of over-production of ROS. Likewise (and vice versa), accumulation of ROS leads to greater sleep pressure. Thus, it is theorized that one of the functions of sleep is to act as the brain’s “antioxidant” at night by clearing oxidation built up from daily stress of the active day phase. In this review, we will highlight evidence linking sleep homeostasis and regulation to redox metabolism by discussing (1) the bipartite role that sleep–wake neuropeptides and hormones have in redox metabolism through comparing cross-species cellular and molecular mechanisms, (2) the evolutionarily metabolic changes that accompanied the development of sleep loss in cavefish, and finally, (3) some of the challenges of uncovering the cellular mechanism underpinning how ROS accumulation builds sleep pressure and cellularly, how this pressure is cleared.

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Section: Sleep-modulating Neuropeptides Hormones and Their Connection...mentioning

confidence: 99%

Phylogenetic conservation of the interdependent homeostatic relationship of sleep regulation and redox metabolism

Terzi,

Ngo,

Mourrain

2024

J Comp Physiol B

View full text Add to dashboard Cite

show abstract

Melatonin improves behavioral parameters and oxidative stress in zebrafish submitted to a leucine-induced MSUD protocol

Cited by 1 publication

References 75 publications

Phylogenetic conservation of the interdependent homeostatic relationship of sleep regulation and redox metabolism

Phylogenetic conservation of the interdependent homeostatic relationship of sleep regulation and redox metabolism

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