Melatonin/HPβCD complex: Microwave synthesis, integration with chitosan scaffolds and inhibitory effects on MG-63CELLS

Topal, Bedriye; Altındal, Damla Çetin; Gümüşderelı́oğlu, Menemşe

doi:10.1016/j.ijpharm.2015.11.028

Cited by 41 publications

(28 citation statements)

References 30 publications

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“…Therefore, the FTIR results conrm the presence of drug into the nanoparticle structure, which is consistent with XRD results. Topal et al 46 also observed similar results in their study. The melatonin complex spectrum in their research also had a few melatonin peaks, which proved the formation of an inclusion complex.…”

Section: Particle Size and Morphology Tem (supporting

confidence: 82%

“…45 The principle peaks of melatonin were observed at 3303 cm À1 (N-H), 1629 cm À1 (C]O), 1555 cm À1 (C-O) and 1212 cm À1 (C-N). 46 The NLC spectrum is comparable to that of GMS, which could be due to high lipid content compared to the amount of drug. This also demonstrates the successful placement of the drug into nanoparticle cavities, as a result of which some melatonin peaks are not visible in the spectrum of NLC and visible peaks are of lower intensity.…”

Section: Particle Size and Morphology Tem (mentioning

confidence: 83%

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Enhanced delivery of melatonin loaded nanostructured lipid carriers duringin vitrofertilization: NLC formulation, optimization and IVF efficacy

et al. 2020

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Section: Particle Size and Morphology Tem (supporting

confidence: 82%

Section: Particle Size and Morphology Tem (mentioning

confidence: 83%

Enhanced delivery of melatonin loaded nanostructured lipid carriers duringin vitrofertilization: NLC formulation, optimization and IVF efficacy

et al. 2020

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“…Owing to the relatively short half-life (30-57 min) of melatonin in the blood [84], melatonin loaded poly(d,l-lactide-co-glycolide) (PLGA) nanoparticles and microparticles have been employed to fortify the inhibitory effect of human osteosarcoma MG-63 cell proliferation, providing an expectation about the usage of melatonin as an adjunct to the routine chemotherapy of osteosarcoma [83]. Moreover, 9 mM of melatonin concentration released from the melatonin/2-hydroxypropyl-β-cyclodextrin (HPβCD) inclusion complex loaded chitosan scaffolds causes time dependent cell death by reducing the proportion of the cells in the G2/M phase rather than the S phase, so the inclusion complex can be considered an alternative system for human osteosarcoma therapy [85]. Table 3.…”

Section: Synergistic Effects and Utilization Of Micro/nanoparticles Dmentioning

confidence: 99%

Molecular and Cellular Mechanisms of Melatonin in Osteosarcoma

Lin

Yang

et al. 2019

Cells

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Osteosarcoma, the most common primary bone malignancy, occurs most frequently in adolescents with a peak of incidence at 11-15 years. Melatonin, an indole amine hormone, shows a wide range of anticancer activities. The decrease in melatonin levels simultaneously concurs with the increase in bone growth and the peak age distribution of osteosarcoma during puberty, so melatonin has been utilized as an adjunct to chemotherapy to improve the quality of life and clinical outcomes. While a large amount of research has been conducted to understand the complex pleiotropic functions and the molecular and cellular actions elicited by melatonin in various types of cancers, a few review reports have focused on osteosarcoma. Herein, we summarized the anti-osteosarcoma effects of melatonin and its underlying molecular mechanisms to illustrate the known significance of melatonin in osteosarcoma and to address cellular signaling pathways of melatonin in vitro and in animal models. Even in the same kind of osteosarcoma, melatonin has been sparingly investigated to counteract tumor growth, apoptosis, and metastasis through different mechanisms, depending on different cell lines. We highlighted the underlying mechanism of anti-osteosarcoma properties evoked by melatonin, including antioxidant activity, anti-proliferation, induction of apoptosis, and the inhibition of invasion and metastasis. Moreover, we discussed the drug synergy effects of the role of melatonin involved and the method to fortify the anti-cancer effects on osteosarcoma. As a potential therapeutic agent, melatonin is safe for children and adolescents and is a promising candidate for an adjuvant by reinforcing the therapeutic effects and abolishing the unwanted consequences of chemotherapies.

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“…However, its employment is limited by a low water solubility (0.002 mol/kg) [ 9 ] and by its relative sensitivity to light [ 10 ]. For these reasons, the studies in the last years have turned towards the creation of a drug-delivery system (DDS) between melatonin and β-cyclodextrin [ 11 , 12 , 13 ], based on their host–guest interaction, maximized with the use of cyclodextrins with seven units of α-D-glucose.…”

Section: Introductionmentioning

confidence: 99%

On the Interactions of Melatonin/β-Cyclodextrin Inclusion Complex: A Novel Approach Combining Efficient Semiempirical Extended Tight-Binding (xTB) Results with Ab Initio Methods

et al. 2021

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Melatonin (MT) is a molecule of paramount importance in all living organisms, due to its presence in many biological activities, such as circadian (sleep–wake cycle) and seasonal rhythms (reproduction, fattening, molting, etc.). Unfortunately, it suffers from poor solubility and, to be used as a drug, an appropriate transport vehicle has to be developed, in order to optimize its release in the human tissues. As a possible drug-delivery system, β-cyclodextrin (βCD) represents a promising scaffold which can encapsulate the melatonin, releasing when needed. In this work, we present a computational study supported by experimental IR spectra on inclusion MT/βCD complexes. The aim is to provide a robust, accurate and, at the same time, low-cost methodology to investigate these inclusion complexes both with static and dynamic simulations, in order to study the main actors that drive the interactions of melatonin with β-cyclodextrin and, therefore, to understand its release mechanism.

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Melatonin/HPβCD complex: Microwave synthesis, integration with chitosan scaffolds and inhibitory effects on MG-63CELLS

Cited by 41 publications

References 30 publications

Enhanced delivery of melatonin loaded nanostructured lipid carriers duringin vitrofertilization: NLC formulation, optimization and IVF efficacy

Enhanced delivery of melatonin loaded nanostructured lipid carriers duringin vitrofertilization: NLC formulation, optimization and IVF efficacy

Molecular and Cellular Mechanisms of Melatonin in Osteosarcoma

On the Interactions of Melatonin/β-Cyclodextrin Inclusion Complex: A Novel Approach Combining Efficient Semiempirical Extended Tight-Binding (xTB) Results with Ab Initio Methods

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