2021
DOI: 10.1111/aji.13402
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Melatonin for the prevention of fetal injury associated with intrauterine inflammation

Abstract: Intrauterine inflammation (IUI) is the inflammation of the chorion, amnion, and placenta. IUI is used interchangeably, considering that inflammation commonly affects the amniotic fluid, fetus, umbilical cord, or placenta, and fetal membranes, or decidua. 1-3 IUI is responsible for 40%-70% of pregnancies ending in preterm delivery because of preterm labor or preterm premature rupture of membrane (PPROM). 4 Untreated inflammation increases the risk of fetal inflammatory response syndrome (FIRS), which may result… Show more

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Cited by 7 publications
(2 citation statements)
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“…Melatonin is primarily produced by the pineal gland and acts through its two G-protein coupled receptors in target tissues, including the pancreas, in which it can regulate insulin production [ 66 ]. Furthermore, melatonin can reduce intrauterine inflammation and prevent preterm birth [ 67 ]. Additional studies will be needed to characterize the mechanisms by which obesity disrupts the uterine peripheral clock, and the impacts this has on both fertility and disease pathogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…Melatonin is primarily produced by the pineal gland and acts through its two G-protein coupled receptors in target tissues, including the pancreas, in which it can regulate insulin production [ 66 ]. Furthermore, melatonin can reduce intrauterine inflammation and prevent preterm birth [ 67 ]. Additional studies will be needed to characterize the mechanisms by which obesity disrupts the uterine peripheral clock, and the impacts this has on both fertility and disease pathogenesis.…”
Section: Discussionmentioning
confidence: 99%
“…Additional considerations for potential interventions could consist of anti-inflammatory agents known to suppress antenatal inflammation in experimental studies, such as glucocorticoids, cytokine suppressors, melatonin and magnesium sulphate, but data on their effect on respiratory drive and spontaneous breathing at birth is scarce [77][78][79][80][81][82]. These agents could lower PGE 2 and adenosine levels by acting on precursors of their inflammatory cascade [77][78][79][80][81][82]. As PGE 2 and adenosine are important messengers also involved in multiple organ systems, lowering normal responses to hypoxia and inflammation might have negative consequences on the brain or other organs (e.g.…”
Section: Possible Interventionsmentioning
confidence: 99%