Melatonin for the prevention of fetal injury associated with intrauterine inflammation

Kim, Jang Mee; Lee, Seung-Yun; Lee, Ji Yeon

doi:10.1111/aji.13402

Cited by 7 publications

(2 citation statements)

References 116 publications

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“…Melatonin is primarily produced by the pineal gland and acts through its two G-protein coupled receptors in target tissues, including the pancreas, in which it can regulate insulin production [ 66 ]. Furthermore, melatonin can reduce intrauterine inflammation and prevent preterm birth [ 67 ]. Additional studies will be needed to characterize the mechanisms by which obesity disrupts the uterine peripheral clock, and the impacts this has on both fertility and disease pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Obesity alters the mouse endometrial transcriptome in a cell context-dependent manner

Wilson

Skalski

Reske

et al. 2022

Reprod Biol Endocrinol

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Obesity impacts fertility and is positively correlated with endometrial hyperplasia and endometrial cancer occurrence. Endometrial epithelia often harbor disease driver-mutations, while endometrial stroma are highly regulative of neighboring epithelia. Here, we sought to determine distinct transcriptome changes occurring in individual cell types in the obese mouse uterus. Outbred CD-1 mice were fed high-fat or control diets for 18 weeks, estrous cycle staged, and endometrial epithelia, macrophages, and stroma isolated for transcriptomic analysis. High-fat diet mice displayed increased body mass and developed glucose intolerance, hyperinsulinemia, and fatty liver. Obese mouse epithelia displayed differential gene expression for genes related to innate immunity and leukocyte chemotaxis. The obese mouse stroma differentially expressed factors related to circadian rhythm, and expression of these genes correlated with glucose tolerance or body mass. We observed correlations between F4/80 + macrophage numbers, Cleaved Caspase 3 (CC3) apoptosis marker staining and glucose intolerance among obese mice, including a subgroup of obese mice with high CC3 + luminal epithelia. This subgroup displayed differential gene expression among all cell types, with pathways related to immune escape in epithelia and macrophages, while the stroma dysregulated pathways related to regulation of epithelia. These results suggest an important role for differential response of both the epithelia and stroma in their response to obesity, while macrophages are dysregulated in the context of apoptotic epithelia. The obesity-related gene expression programs in cells within the uterine microenvironment may influence the ability of the endometrium to function during pregnancy and influence disease pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Obesity alters the mouse endometrial transcriptome in a cell context-dependent manner

Wilson

Skalski

Reske

et al. 2022

Reprod Biol Endocrinol

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show abstract

“…Additional considerations for potential interventions could consist of anti-inflammatory agents known to suppress antenatal inflammation in experimental studies, such as glucocorticoids, cytokine suppressors, melatonin and magnesium sulphate, but data on their effect on respiratory drive and spontaneous breathing at birth is scarce [77][78][79][80][81][82]. These agents could lower PGE 2 and adenosine levels by acting on precursors of their inflammatory cascade [77][78][79][80][81][82]. As PGE 2 and adenosine are important messengers also involved in multiple organ systems, lowering normal responses to hypoxia and inflammation might have negative consequences on the brain or other organs (e.g.…”

Section: Possible Interventionsmentioning

confidence: 99%

The influence of chorioamnionitis on respiratory drive and spontaneous breathing of premature infants at birth: a narrative review

Panneflek,

Kuypers,

Polglase

et al. 2024

Eur J Pediatr

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Most very premature infants breathe at birth but require respiratory support in order to stimulate and support their breathing. A significant proportion of premature infants are affected by chorioamnionitis, defined as an umbrella term for antenatal inflammation of the foetal membranes and umbilical vessels. Chorioamnionitis produces inflammatory mediators that potentially depress the respiratory drive generated in the brainstem. Such respiratory depression could maintain itself by delaying lung aeration, hampering respiratory support at birth and putting infants at risk of hypoxic injury. This inflammatory-mediated respiratory depression may contribute to an association between chorioamnionitis and increased requirement of neonatal resuscitation in premature infants at birth. This narrative review summarises mechanisms on how respiratory drive and spontaneous breathing could be influenced by chorioamnionitis and provides possible interventions to stimulate spontaneous breathing. Conclusion: Chorioamnionitis could possibly depress respiratory drive and spontaneous breathing in premature infants at birth. Interventions to stimulate spontaneous breathing could therefore be valuable. What is Known:• A large proportion of premature infants are affected by chorioamnionitis, antenatal inflammation of the foetal membranes and umbilical vessels. What is New:• Premature infants affected by chorioamnionitis might be exposed to higher concentrations of respiratory drive inhibitors which could depress breathing at birth.• Premature infants affected by chorioamnionitis seem to be associated with a higher and more extensive requirement of resuscitation at birth.

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Melatonin alleviates high temperature exposure induced fetal growth restriction via the gut-placenta-fetus axis in pregnant mice

Wu,

Zheng,

et al. 2024

Journal of Advanced Research

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Melatonin for the prevention of fetal injury associated with intrauterine inflammation

Cited by 7 publications

References 116 publications

Obesity alters the mouse endometrial transcriptome in a cell context-dependent manner

Obesity alters the mouse endometrial transcriptome in a cell context-dependent manner

The influence of chorioamnionitis on respiratory drive and spontaneous breathing of premature infants at birth: a narrative review

Melatonin alleviates high temperature exposure induced fetal growth restriction via the gut-placenta-fetus axis in pregnant mice

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