Melatonin expression in periodontal disease

Gómez‐Moreno, Gerardo; Cutando-Soriano, Antonio; Arana, Carlos; Galindo, Pablo; Bolaños, Jorge; Acuña-Castroviejo, Darı́o; Wang, H.-L.

doi:10.1111/j.1600-0765.2007.00978.x

Cited by 55 publications

(78 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This study also reported that the melatonin levels in saliva and gingival crevicular fluid were similar (with no significant differences), confirming the results obtained in previous studies [62]. In the study carried out by Gómez-Moreno [63], the authors found that patients with periodontal disease had a significantly lower plasma and salivary level of melatonin, maintaining a similar salivary/plasma melatonin ratio to that of the healthy subjects.…”

Section: Resultssupporting

confidence: 89%

“…The authors explained this as a consequence of the oral inflammatory mediators. In the remaining studies, the correlation between salivary melatonin levels and periodontal disease was negative [61,62,63]. …”

Section: Resultsmentioning

confidence: 99%

“…The protective role of melatonin on periodontal tissues might be explained to some extent by its antimicrobial action [60], its activation of the immune system [89], and its anti-inflammatory and free radical scavenger effect [90]. In addition, melatonin may modulate periodontal destruction by inhibiting prostaglandin E 2 synthesis and, therefore, inhibit osteoclast differentiation [91], neutralising reactive oxygen species at the level of osteoclast lacuna, with the inhibition of bone resorption and stimulating osteoblast differentiation [30,63]. …”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Permuy

López-Peña

González‐Cantalapiedra

et al. 2017

IJMS

View full text Add to dashboard Cite

Melatonin is a hormone synthesised and secreted by the pineal gland and other organs. Its secretion, controlled by an endogenous circadian cycle, has been proven to exert immunological, anti-oxidant, and anti-inflammatory effects that can be beneficial in the treatment of certain dental diseases. This article is aimed at carrying out a review of the literature published about the use of melatonin in the dental field and summarising its potential effects. In this review article, an extensive search in different databases of scientific journals was performed with the objective of summarising all of the information published on melatonin use in dental diseases, focussing on periodontal diseases and dental implantology. Melatonin released in a natural way into the saliva, or added as an external treatment, may have important implications for dental disorders, such as periodontal disease, as well as in the osseointegration of dental implants, due to its anti-inflammatory and osseoconductive effects. Melatonin has demonstrated to have beneficial effects on dental pathologies, although further research is needed to understand the exact mechanisms of this molecule.

show abstract

Section: Resultssupporting

confidence: 89%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Melatonin: A Review of Its Potential Functions and Effects on Dental Diseases

Permuy

López-Peña

González‐Cantalapiedra

et al. 2017

IJMS

View full text Add to dashboard Cite

show abstract

“…Periodontitis is a chronic inflammatory disease caused by dental plaque microorganisms, and is characterized by the destruction of supporting tissues (bone and connective tissue) and loss of teeth (1,2). The progression of periodontal disease depends on the host's response to the bacteria and bacterial products, and this often leads to systemic inflammation (3).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant effects of melatonin in heart tissue after induction of experimental periodontitis in rats

Özdem

Kırzıoğlu

Yilmaz

et al. 2017

Journal of Oral Science

View full text Add to dashboard Cite

The aim of this study was to evaluate the effects of melatonin on the oxidative stress in heart tissues after induction of experimental periodontitis in rats. Thirty Wistar Albino male rats were divided into four groups as follows: healthy + saline solution (Hs, n = 7), healthy + melatonin (Hm, n = 7), periodontitis + saline solution (Ps, n = 8), and periodontitis + melatonin (Pm, n = 8). Experimental periodontitis was induced using a ligature placed at the gingival margin of the maxillary second molars. Melatonin was applied intraperitoneally (10 mg/ kg) every day for 2 weeks. After sacrificing the rats, serum levels of malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) levels, and melatonin levels were evaluated. The Pm group exhibited lower alveolar bone loss than the Ps group. Melatonin levels increased in the periodontitis groups, and the Pm group had lower MDA levels and higher GSH-Px levels than the Ps group. These findings suggest that melatonin administration reduces MDA and increases GSH-Px levels in heart tissue, and these effects may be due to its antioxidant properties.Further studies are needed to understand the effects of melatonin on the association between periodontitis and cardiovascular disease.

show abstract

“…Many of its effects differ to its primary neurohormonal functions and are due to its anti-inflammatory properties, its ability to be an effective freeradical scavenger and for the stimulation of several antioxidant enzymes (Allegra et al, 2003;Czesnikiewicz-Guzik et al, 2007). In response to the inflammation of periodontal disease, increased levels of plasma melatonin may be induced, leading to an increase in salivary melatonin, where this indoleamine may exert a protective role during the periodontal inflammatory process due to its anti-inflammatory and anti-oxidant effects (G omez-Moreno et al, 2007;G omez-Florit et al, 2013).…”

Section: Introductionmentioning

confidence: 99%