Melatonin exerts a more potent effect than S-adenosyl-l-methionine against iron metabolism disturbances, oxidative stress and tissue injury induced by obstructive jaundice in rats

Muñoz‐Castañeda, Juan R.; Túnez, Isaac; Herencia, Carmen; Ranchal, Isidora; González, Raúl; Ramírez, Luz María; Arjona, Álvaro; Barcos, Montserrat; Espejo, Isabel; Cruz, Antonio Míguez Santa; Montilla, Pedro; Padillo, Francisco J.; Muntané, Jordi

doi:10.1016/j.cbi.2008.05.016

Cited by 10 publications

(8 citation statements)

References 44 publications

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“…Iron is required for the initial steps of Fas-mediated apoptosis and caspase activation, which aggravated tissue injury by increasing apoptosis [ 25 , 26 ]. The elevated iron activated caspase3 via enhanced oxidative stress contributes to hepatic apoptosis and the development of liver injury [ 27 ]. Therefore, it is suspected that iron overload promotes the formation of ROS and lipid peroxidation, which subsequently acting as markers of apoptosis or participated in caspase-3-mediated hepatocyte apoptosis in C. sinensis infection.…”

Section: Discussionmentioning

confidence: 99%

Hepatic iron overload is associated with hepatocyte apoptosis during Clonorchis sinensis infection

et al. 2017

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BackgroundHepatic iron overload has been implicated in many liver diseases; however, whether it is involved in clonorchiasis remains unknown. The purpose of this study is to investigate whether Clonorchis sinensis (C. sinensis) infection causes hepatic iron overload, analyze the relationship between the iron overload and associated cell apoptosis, so as to determine the role of excess iron plays in C. sinensis-induced liver injury.MethodsThe Perls’ Prussian staining and atomic absorption spectrometry methods were used to investigate the iron overload in hepatic sections of wistar rats and patients infected with C. sinensis. The hepatic apoptosis was detected by transferase uridyl nick end labeling (TUNEL) methods. Spearman analysis was used for determining the correlation of the histological hepatic iron index and the apoptotic index.ResultsBlue iron particles were deposited mainly in the hepatocytes, Kupffer cells and endothelial cells, around the liver portal and central vein area of both patients and rats. The total iron score was found to be higher in the infected groups than the respective control from 8 weeks. The hepatic iron concentration was also significantly higher in treatment groups than in control rats from 8 weeks. The hepatocyte apoptosis was found to be significantly higher in the portal area of the liver tissue and around the central vein. However, spearman’s rank correlation coefficient revealed that there was a mildly negative correlation between the iron index and hepatocyte apoptosis.ConclusionsThis present study confirmed that hepatic iron overload was found during C. sinensis infection. This suggests that iron overload may be associated with hepatocyte apoptosis and involved in liver injury during C. sinensis infection. Further studies are needed to investigate the molecular mechanism involved here.

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Section: Discussionmentioning

confidence: 99%

Hepatic iron overload is associated with hepatocyte apoptosis during Clonorchis sinensis infection

et al. 2017

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“…These functions are clearly important under stressful conditions, but production of cystathionine is also important as one of the end products of the transulfuration pathway is glutathione, a potent antioxidant. Intermediates in this pathway such as S-adenosylmethionine stimulate antioxidant activities (Tchantchou et al, 2008) and have been shown to be active against oxidative stress, inflammation and lipid peroxidation (Muñoz-Castañeda et al, 2008;Erdmann et al, 2008;Malakar et al, 2008). Whether one of these activities is paramount in the Harpagifer response is unknown, it may be a combination of several, given the complexity of the reaction pathways and the importance of their end products on cellular homeostasis.…”

Section: Homocysteine Metabolismmentioning

confidence: 97%

Transcription profiling of acute temperature stress in the Antarctic plunderfish Harpagifer antarcticus

et al. 2010

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“…Administration of the pineal hormone appears to reduce the rise in serum enzyme levels of aspartate transaminase, alanine transaminase, lactate dehydrogenase, alkaline phosphatase, γ glutamyl transferase and bilirubin after almost all types of injury, indicating that the extent of cell damage was reduced [66][67][68]77,[83][84][85][86][87][88][89][90][91][92][94][95][96][98][99][100][101][102][103][111][112][113][114][116][117][118][119][120][125][126][127][130][131][132][133][134][135][136][137][138][139][140][141][142][143]…”

Section: Hepatocellular Integritymentioning

confidence: 99%

Hepatoprotective actions of melatonin: Possible mediation by melatonin receptors

Mathes¹

2010

WJG

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Melatonin, the hormone of darkness and messenger of the photoperiod, is also well known to exhibit strong direct and indirect antioxidant properties. Melatonin has previously been demonstrated to be a powerful organ protective substance in numerous models of injury; these beneficial effects have been attributed to the hormone's intense radical scavenging capacity. The present report reviews the hepatoprotective potential of the pineal hormone in various models of oxidative stress in vivo, and summarizes the extensive literature showing that melatonin may be a suitable experimental substance to reduce liver damage after sepsis, hemorrhagic shock, ischemia/reperfusion, and in numerous models of toxic liver injury. Melatonin's influence on hepatic antioxidant enzymes and other potentially relevant pathways, such as nitric oxide signaling, hepatic cytokine and heat shock protein expression, are evaluated. Based on recent literature demonstrating the functional relevance of melatonin receptor activation for hepatic organ protection, this article finally suggests that melatonin receptors could mediate the hepatoprotective actions of melatonin therapy.

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Melatonin exerts a more potent effect than S-adenosyl-l-methionine against iron metabolism disturbances, oxidative stress and tissue injury induced by obstructive jaundice in rats

Cited by 10 publications

References 44 publications

Hepatic iron overload is associated with hepatocyte apoptosis during Clonorchis sinensis infection

Hepatic iron overload is associated with hepatocyte apoptosis during Clonorchis sinensis infection

Transcription profiling of acute temperature stress in the Antarctic plunderfish Harpagifer antarcticus

Hepatoprotective actions of melatonin: Possible mediation by melatonin receptors

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