Melatonin: Effects on brain and behavior

Datta, Purna C.; King, Maurice G.

doi:10.1016/0149-7634(80)90034-2

Cited by 94 publications

(21 citation statements)

References 48 publications

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“…cells by the gland and thereby allow it to exert influences on various neurotransmitter systems and homeostatic functions including, among others, regulation of brain monoamines (Aldegunde et al, 1985;Anton-Tay et al, 1971;Bradbury et al, 1985;Sugden & Morris, 1979;Wendel et al, 1974;Nair et al, 1986), opioid peptide (Kumar et al, 1984;Lissoni et al, 1986). Melanocyte-stimulating hormone (MSH) release (Kastin et al, 1967;Kastin et al, 1972), endocrine regulation (Datta & King, 1978;Erlich & Apuzzo, 1985), thermoregulation (Kavaliers, 1982;Hutchison et al, 1979), and regulation of pain mechanisms (Kavaliers et al, 1983;Lakin et al, 1981). In addition, it has been suggested that the pineal gland acts as a "biological clock," as a neuroendocrine transducer" and as a "central inhibitory modulator" and its functions have been thought to exert long lasting effects on the CNS (Datta & King, 1978).…”

Section: Tablementioning

confidence: 97%

Pineal Melatonin Functions: Possible Relevance to Parkinson's Disease

Sandyk

1990

International Journal of Neuroscience

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Barbeau hypothesized that Parkinson's disease is associated with hypothalamic deficiency of the specialized neuroendocrine cell system (A.P.U.D.) and that the degeneration of brainstem monoaminergic neurons is secondary to progressive functional loss of this cell system in the disease. The pineal gland meets criteria of the A.P.U.D. cell system and it is possible that dysfunction of the pineal gland may be associated with the pathophysiology and clinical manifestations of Parkinson's disease. Since the role of pineal melatonin in humans remains enigamatic, it is currently unclear which of the symptoms of Parkinson's disease may be associated with deregulation of the secretory activity of pineal melatonin. This review summarizes evidence linking possible alterations of pineal melatonin functions with the clinical manifestations of Parkinson's disease.

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Section: Tablementioning

confidence: 97%

Pineal Melatonin Functions: Possible Relevance to Parkinson's Disease

Sandyk

1990

International Journal of Neuroscience

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“…In fact, it has been proposed that lower nocturnal melatonin may be a trait-dependent marker for depression [21,22]. Pharmacological investigations have also supported the notion of an antidepressive potential for melatonin [21,22].…”

Section: Introductionmentioning

confidence: 95%

“…Pharmacological investigations have also supported the notion of an antidepressive potential for melatonin [21,22].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Gonadectomy on Anxiolytic and Antidepressant Effects of Melatonin in Male and Female Wistar Rats: A Possible Implication of Sex Hormones

Zahra¹,

Lagbouri²,

Mesfioui³

et al. 2012

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The main objective of this study was to analyze the effects of sex, ovariectomy (Ovx) and orchidectomy (Orx) on antidepressant and anxiolytic effect of melatonin in forced swimming test, open field test and elevated plus maze test. Initially, 4 mg/kg of melatonin was daily administered, at 4:00 pm, to intact male and female rats during 8 weeks. Our results have shown that the effect of chronic injection of Mel is sex dependent in the three behaviors tests. Females rats have responded better than males in behavior test study after administration of melatonin, this difference between the sexes may be related to the action of sex hormones (androgens and estrogens) on behavior in males as well as in females. Secondly, to determine the possible interaction between Melatonin and steroid hormones, Ovx/sham female received Mel at dose of 4 mg/kg alone or NaCl (0.9%) alone, and Orx/sham male received Mel at dose of 4 mg/kg alone or NaCl (0.9%) alone daily and during 8 weeks of treatment at 4:00 pm. All animals were tested in the open-field test, elevated plus maze test for anxiety behavior study, and forced swimming test for depression behavior study. Results revealed that Mel exerts an anxiolytic and antidepressant effects in the orchidectomized males and in intact females, confirming that the suppression of androgens by orchidectomy improved anxiolytic and antidepressant effects of melatonin in males. However in females, the suppression of estrogen by ovariectomy masked the antidepressant and anxiolytic effects of melatonin. Our results confirmed that the antidepressant and anxiolytic effects of melatonin are linked to sex hormones.

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“…Mental and sexual arousal, improved attention and concentration, mood elevation, increased appetite, and improved sleep with abundant dreams, are some of the more prominent behavioral effects reported by the majority of patients who received magnetic treatment. Such "energizing" effects had not been experienced previously by these patients during treatment with anticholinergics, levodopa, or dopamine receptor agonists and are in accord with the involvement of the pineal gland in the regulation of diverse functions such as alertness, sleep, mood, pain, sexual functions, and feeding behavior (Pazo, 1979;Datta & King, 1980;Erlich & Apuzzo, 1985;Miles & Philbrick, 1988).…”

Section: Proposed Mode Of Action Of Magnetic Fieldsmentioning

confidence: 60%

“…The pineal gland, previously considered a vestigial organ, is now recognized to exert complex modulatory functions in the CNS (Mullen & Silman, 1977; Datta & King, 1980; Erlich & Apuzzo, 1985). There is now greater recognition that the expressions of various neuropsychiatric disorders such as mania, depression, panic disorders, bulimia nervosa, obsessive-compulsive disorder, suicide, cocaine addiction, Tourette's syndrome, schizophrenia, epilepsy, and multiple sclerosis, are influenced by circadian changes in the intensity of various environmental cues such as light, temperature, and magnetic fields (Janz, Sandyk & Kanofsky, in press;.…”

Section: The Futurementioning

confidence: 99%