Melatonin as potential inducer of Th17 cell differentiation

Куклина, Е. М.

doi:10.1016/j.mehy.2014.07.006

Cited by 12 publications

(9 citation statements)

References 41 publications

(58 reference statements)

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“…Additionally, melatonin has been reported as a potential inducer of Th17 response . In contrast, others authors indicate that melatonin treatment decreases the intracellular levels of IL‐17A .…”

Section: Discussionmentioning

confidence: 98%

Interleukin‐17, oxidative stress, and inflammation: role of melatonin during Trypanosoma cruzi infection

Brazão

Colato

Santello

et al. 2015

Journal of Pineal Research

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Although the exact etiology of Chagas' disease remains unknown, the inflammatory process and oxidative stress are believed to be the main contributors to the dysfunction and pathogenesis during chronic Trypanosoma cruzi infection. Our hypothesis is that melatonin administered for 2 months daily could modulate the oxidative stress and the inflammatory response during the chronic infection. Flow cytometric analysis of macrophages and antigen-presenting cells (APC), expression of RT1B as well as LFA-1 and MCP-1 in CD4(+) and CD8(+) T cells and levels of interleukin-17A were assessed. The oxidative stress was evaluated through lipid peroxidation (LPO) analysis on the plasma of thiobarbituric acid-reactive substances (TBARS) and nitric oxide production. Decreased concentrations of nitrite and TBARS were found in infected and melatonin-treated animals, as well as a rising trend in the production of IL-17A as compared to infected and untreated counterparts. A significant decrease was found in the percentages of CD4(+) and CD8(+) T lymphocytes MCP-1 producers for infected and melatonin-treated rats. Reduced percentage of CD8(+) T cells producing LFA-1 was observed in control and melatonin-treated animals as compared to untreated rats. The cellular response of peritoneal APC cells and macrophages significantly dropped in infected and treated animals. As an endpoint, the use of antioxidant compounds such as melatonin emerges as a new and promising approach to control the oxidative stress during the chronic Chagas' disease partially mediated through the abrogation of LPO and the prevention of the inflammatory response and can be used for further investigation on treatment trials for other infectious diseases.

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Section: Discussionmentioning

confidence: 98%

Interleukin‐17, oxidative stress, and inflammation: role of melatonin during Trypanosoma cruzi infection

Brazão

Colato

Santello

et al. 2015

Journal of Pineal Research

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show abstract

“…39,40 The immunostimulatory and antiapoptotic roles of melatonin are exerted mainly through its action on T helper (Th) lymphocytes ( Figure 3). 47 It has become increasingly clear that melatonin also affects innate immune function, including monocytes/macrophages, dendritic cells, polymorphonuclear granulocytes, neutrophils, eosinophils, basophils, mast cells, and natural killer (NK) cells. 37 Increasing concentrations of melatonin induce T-cell proliferation in a dose-dependent way.…”

Section: Mel Atonin a S A P Otential Immunoreg Ul Atormentioning

confidence: 99%

“…On the other hand, the function of Th17 must undergo alterations under the conditions associated with the melatonin level alterations. 47 It has become increasingly clear that melatonin also affects innate immune function, including monocytes/macrophages, dendritic cells, polymorphonuclear granulocytes, neutrophils, eosinophils, basophils, mast cells, and natural killer (NK) cells. 48 What deserves our attention is the role of melatonin in monocyte/macrophage system and NK cells ( Figure 3).…”

Section: Mel Atonin a S A P Otential Immunoreg Ul Atormentioning

confidence: 99%

Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome

Yang

Zhou

et al. 2018

American J Rep Immunol

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Melatonin is a neurohormone synthesized from the aromatic amino acid tryptophan mainly by the pineal gland of mammals. Melatonin acts as a broad-spectrum antioxidant, powerful free radical scavenger, anti-inflammatory agent, anticarcinogenic factor, sleep inducer and regulator of the circadian rhythm, and potential immunoregulator. Melatonin and reproductive system are interrelated under both physiological and pathological conditions. Oxidative stress, inflammation, and immune dysregulation are associated with the pathogenesis of the female reproductive system which causes endometriosis (EMS), recurrent spontaneous abortion (RSA), and polycystic ovary syndrome (PCOS). Accumulating studies have indicated that melatonin plays pleiotropic and essential roles in these obstetrical and gynecological disorders and would be a candidate therapeutic drug to regulate inflammation and immune function and protect special cells or organs. Here, we systematically review the pleiotropic roles of melatonin in EMS, RSA, and PCOS to explore its pathological implications and treatment potential.

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“…Наиболее очевидной мишенью действия мелатонина в иммунной системе при данной патологии является субпопуляция Т-лимфоцитов, продуцирующих IL-17 (Th17). С одной стороны, теоретически, эта субпопуляция должна находиться под непосредственным контролем мелатонина [9,10]. С другой стороны, именно Th17-клеткам в настоящее время отводится ключевая роль в патогенезе РС -активация Th17 провоцирует нейровоспаление, а сдвиг баланса между Th17 и регуляторными Т-клетками (Treg) приводит к срыву иммунной толерантности и, как следствие, развитию аутоиммунных процессов [11,12].…”

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Melatonin as an inducing factor for multiple sclerosis

2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Melatonin is one of the most multifunctional regulators in the organism. It plays a key role in the control of nerve, endocrine, and immune systems. Due to hormone neuroprotective activity, the possibility is now discussed on its clinical usage in treating neurodegenerative diseases, including multiple sclerosis. At the same time, melatonin is an effective regulator of immune reactions, in part, the reactions toward autoantigens. In this respect, the subset ofT lymphocytes producing IL-17 (Th17) is of special interest. As the Th17 subset plays a key role iri multiple sclerosis pathogenesis, the immunomodulating hormone effects toward Th17, may, in theory, nullify its positive neuroprotective activity.

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Melatonin as potential inducer of Th17 cell differentiation

Cited by 12 publications

References 41 publications

Interleukin‐17, oxidative stress, and inflammation: role of melatonin during Trypanosoma cruzi infection

Interleukin‐17, oxidative stress, and inflammation: role of melatonin during Trypanosoma cruzi infection

Pleiotropic roles of melatonin in endometriosis, recurrent spontaneous abortion, and polycystic ovary syndrome

Melatonin as an inducing factor for multiple sclerosis

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