Melatonin as pharmacologic support in burn patients: A proposed solution to thermal injury–related lymphocytopenia and oxidative damage

Maldonado, Mónica; Murillo-Cabezas, Francisco; Calvo, Juan R.; Lardone, Patricia Judith; Tan, Dun Xian; Guerrero, Juan M.; Reiter, R. J.

doi:10.1097/01.ccm.0000259380.52437.e9

Cited by 50 publications

(32 citation statements)

References 116 publications

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“…CRP produced by activated leukocytes itself stimulates the expression of cytokines and free radical production which can lead to progression of tissue oxidative damage [39,40]. Protective effect of melatonin is related not only to the inhibition of inflammatory cytokines but also to the reduction of the expression of adhesion molecules after burns [8]. Exogenous melatonin protects the liver by ischemia/reperfusion injury inhibiting the production of free radicals, reducing TNF-α concentration in systemic circulation and suppressing intercellular adhesion molecule-1 (ICAM-1) liver expression [41].…”

Section: Early Inflammatory Response Post-burn Liver Injury and Apopmentioning

confidence: 99%

“…By means of pleotropic function of an antioxidant, anti-inflammatory and anti-apoptotic mediator, melatonin protects against burn-induced liver damage and improves survival of rats after burns [8][9][10].…”

Section: Early Inflammatory Response Post-burn Liver Injury and Apopmentioning

confidence: 99%

“…It stimulates the activity of a variety of antioxidant enzymes [7] and reduces cytokine production [8][9][10]. Melatonin could modulate inflammation by decreasing the NF-κB activation cascade and oxidative stress by increasing the nuclear expression of erythroid Nrf2 which might be responsible, at least in part, for its hepato-protective effect [11].…”

Section: Introductionmentioning

confidence: 99%

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Melatonin protection against burn-induced liver injury. A review

et al. 2014

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AbstractSevere thermal injury may be complicated by dysfunction of organs distant from the original burn wound, including the liver, and represents a serious clinical problem. Although pathophysiology of burn-induced liver injury remains unclear, increasing evidence implicate activation of inflammatory response, oxidative stress, endothelial dysfunction and microcirculatory disorders as the main mechanisms of hepatic injury. Several studies suggest melatonin as a multifunctional indolamine that counteracts some of the pathophysiologic steps and displays significant beneficial effects against burn-induced cellular injury. This review summarizes the role of melatonin in restricting the burn-induced hepatic injury and focuses on its effects on oxidative stress, inflammatory response, endothelial dysfunction and microcirculatory disorders as well as on signaling pathways such as regulation of nuclear erythroid 2-related factor 2 (Nrf2) and nuclear factor-kappaB (NF-kB). Further studies are necessary to elucidate the modulating effect of melatonin on the transcription factor responsible for the regulation of the pro-inflammatory and antioxidant genes involved in burn injuries.

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Section: Early Inflammatory Response Post-burn Liver Injury and Apopmentioning

confidence: 99%

Section: Early Inflammatory Response Post-burn Liver Injury and Apopmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Melatonin protection against burn-induced liver injury. A review

et al. 2014

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“…This hormone is known to regulate the circadian rhythms induced by a short light dark cycle and the circadian rhythms [14,15]. A number of studies demonstrate that melatonin is an interesting pharmacological agent in the treatment of inflammatory conditions [8][9][10][11][12][13][14][15][16]. The beneficial effect of melatonin in these studies is associated with: 1) antioxidant effect of this indole and 2) modulation of the inflammatory response.…”

Section: Antioxidative and Anti-inflammatory Effect Of Melatoninmentioning

confidence: 99%

“…It passes freely through membranes and distributes in all subcellular compartments [5]. These evidences suggest that these pleiotropic functions of melatonin may be used clinically under conditions where its circulating levels are reduced [9,10]. Because of its antioxidant, anti-inflammatory and anti-apoptotic effects, exogenous melatonin attenuates ischemia/reperfusion and hepatotoxins induced liver injury [11][12][13].…”

Section: Soj Immunologymentioning

confidence: 99%

Melatonin Ameliorates Burn-Induced Liver Injury by Modulation of Nrf2 and Nf- kB Signaling Pathways

Bekyarova¹,

Tzaneva²

2015

SOJI

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SOJ ImmunologyOpen Access Mini Review oxidative status and the inflammatory response, it is logical to hypothesize that therapy with substances possessing antioxidant, anti-inflammatory and anti-apoptotic effects may be beneficial in reducing these complications.Melatonin (N-acetyl-5-methoxytryptamine) is secreted in the pineal gland and extra pineal tissues. Melatonin possesses a wide variety of biological effects such as chronobiological, sedative and anxiolytic. Melatonin may act as an antioxidant and a potent scavenger of both oxygen and nitrogen reactive molecules. The free radical scavenging activity of melatonin is receptor independent process whereas the indirect effect likely involves specific receptors [6]. Melatonin stimulates the activity of enzymes involved in antioxidant defense and reduces the production of proinflammatory mediators [7,8]. Melatonin is a small, highly lipophilic and hydrophilic molecule. It passes freely through membranes and distributes in all subcellular compartments [5]. These evidences suggest that these pleiotropic functions of melatonin may be used clinically under conditions where its circulating levels are reduced [9,10]. Because of its antioxidant, anti-inflammatory and anti-apoptotic effects, exogenous melatonin attenuates ischemia/reperfusion and hepatotoxins induced liver injury [11][12][13]. Antioxidative and anti-inflammatory effect of melatoninMelatonin participates in the regulation of important physiological processes. This hormone is known to regulate the circadian rhythms induced by a short light dark cycle and the circadian rhythms [14,15]. A number of studies demonstrate that melatonin is an interesting pharmacological agent in the treatment of inflammatory conditions [8][9][10][11][12][13][14][15][16]. The beneficial effect of melatonin in these studies is associated with: 1) antioxidant effect of this indole and 2) modulation of the inflammatory response.A large body of evidence indicates that melatonin is a major Scavenger of Radical Oxygen Species (ROS) and Reactive nitrogen (RNS species and activator of antioxidant enzymes [17][18][19]. Under normal conditions ROS and RNS are produced in mitochondria and they are neutralized by non enzymatic AbsractSevere thermal injury is a common traumatic injury that results in local tissue damage and systemic response and represents a serious clinical problem. A skin burn leads to dysfunction of organs distant from the original burn skin injury, including the liver. The pathophysiology of burn-induced liver injury is very complicated and remains unclear. Increasing evidence implicate activation of the inflammatory response along with the oxidative stress as the main mechanisms of hepatic injury in burns. Melatonin is a multifunctional molecule that might counteract all pathophysiologic steps and displays beneficial effects against cellular damage, induced by thermal injury. This review summarises protective effect of melatonin on hepatic injury related with suppression of oxidative stress, inflammatory response and ap...

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Melatonin as a potential therapeutic agent in psychiatric illness

Maldonado

Reíter

Pérez-San-Gregorio

2009

Human Psychopharmacology

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The aim of this review was to summarize the potential use of melatonin in the treatment of mental disorders, specifically bipolar disorders, depression, and schizophrenia. To date, melatonin has been most commonly used in psychiatry because of its hypnotic, rhythm resynchronizing, and antioxidant actions. Here, we examine other properties of the melatonin including its anti-inflammatory, antinociceptive, anxiolytic, and drug detoxification actions as well as its protective effects against neural loss. The brain is an intricate sensory and motor organ which receives information from both the external and internal environments. It transduces information into complex chemical and electrical signals which are transmitted throughout the central nervous system (CNS) and the organism. The pathogenesis of mental disorders remains ambiguous and neuroinflammation has been proposed as a causative agent. We consider the potential contributions of melatonin as therapeutic agent in CNS and during neuroinflammation in mental disorders.

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Melatonin as pharmacologic support in burn patients: A proposed solution to thermal injury–related lymphocytopenia and oxidative damage

Abstract: These combined actions of melatonin, along with its low toxicity and its ability to penetrate all morphophysiologic membranes, could make it a ubiquitously acting and highly beneficial molecule in burn patients.

Cited by 50 publications

References 116 publications

Melatonin protection against burn-induced liver injury. A review

Melatonin protection against burn-induced liver injury. A review

Melatonin Ameliorates Burn-Induced Liver Injury by Modulation of Nrf2 and Nf- kB Signaling Pathways

Melatonin as a potential therapeutic agent in psychiatric illness

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