Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa

Espino, Javier; Bejarano, Ignacio; Ortiz, Águeda; Lozano, Graciela M.; Garcı́a, Juan; Pariente, José A.; Rodríguez, Ana B.

doi:10.1016/j.fertnstert.2009.12.082

Cited by 88 publications

(70 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The regulator role of melatonin in apoptosis and mitochondrial depolarization was reported in human neutrophils (Espino et al, 2010(Espino et al, , 2011a(Espino et al, , 2011b. In a recent study we also reported the modulator role of melatonin on the apoptosis level and TRPM2 channel activity in a transfected Chinese hamster ovary cell line (Celik and Nazıroğlu, 2012).…”

Section: Melatonin and Trp Channelsmentioning

confidence: 66%

Role of melatonin on calcium signaling and mitochondrial oxidativestress in epilepsy: focus on TRP channels

Nazıroğlu¹

2015

Turk J Biol

View full text Add to dashboard Cite

Calcium ion (Ca 2+ ) accumulation and excessive oxidative stress in the hippocampus and brain cortex have long been known as major contributors to the etiology of epilepsy. I have reviewed the role of Ca 2+ signaling through cation channels and mitochondriamediated oxidative stress on epilepsy in human and animals. A review of the relevant papers and results from recent studies were obtained from PubMed and the Science Citation Index. Current literature findings indicate that melatonin and agomelatine reduce activation of hippocampal transient receptor potential (TRP), glutamate receptors, and voltage-gated calcium channels that are critical for the development of abnormal Ca 2+ homeostasis and oxidative stress and associated mitochondrial dysfunction. In addition, low doses of melatonin induce anticonvulsant action through increase of GABA levels in the hippocampus and brain cortex. The accumulating evidence implicates a modulator role of melatonin on excessive oxidative stress products, plus mitochondrial and Ca 2+ dysregulations in epilepsy. The evidence indicates that modulation of oxidative stress and neuronal Ca 2+ handling occurs through effects on TRP channels, suggesting an increasingly viable approach for therapeutic interventions against epilepsy.

show abstract

Section: Melatonin and Trp Channelsmentioning

confidence: 66%

Role of melatonin on calcium signaling and mitochondrial oxidativestress in epilepsy: focus on TRP channels

Nazıroğlu¹

2015

Turk J Biol

View full text Add to dashboard Cite

show abstract

“…In this context, for preventing harmful effects of oxidative stress, many antioxidant agents, such as vitamin E, melatonin, retinol, β-carotene, omega-3, resveratrol, allopurinol, melatonin, Nacetylcysteine, zinc aspartate, and caffeic acid phenethyl ester, vitamin C, coenzyme Q10, and acetylcysteine have been used with different success rates. [46][47][48][49][50] Although numerous experimental animal studies have confirmed the efficacy of antioxidants in reducing short-term damaging effects of testicular torsion, different antioxidant agents have been investigated to reduce the short-and long-term reperfusion damage on the testes. Anti-apoptotic, anti-inflammatory, and antioxidant properties of oxytocin have been reported.…”

Section: Discussionmentioning

confidence: 99%

Oxytocin in The Prevention of Injury Due to Testicular Torsion/Detorsion in Rats

Fırat¹,

Erdemır²,

Kölükçü³

et al. 2017

Ulus Travma Acil Cerrahi Derg

View full text Add to dashboard Cite

show abstract

“…52 Moreover, pre-exposure of human spermatozoa to antioxidants, such as melatonin or catalase, will prevent this apoptotic response. 53,54 Such an apoptotic cascade can also be precipitated by a variety of factors that induce oxidative stress in spermatozoa by triggering free radical generation by the mitochondria, including exposure to radiofrequency electromagnetic radiation, 21 treatment with unsaturated fatty acids 48 and dosing with the phosphatidylinositol 3-kinase inhibitor, wortmannin (Koppers AJ and Aitken RJ, unpubl. obs.…”

Section: Mitochondrial Ros and Apoptosismentioning

confidence: 99%

Apoptosis and DNA damage in human spermatozoa

Aitken¹,

Koppers²

2010

Asian J Androl

286

179

View full text Add to dashboard Cite

DNA damage is frequently encountered in spermatozoa of subfertile males and is correlated with a range of adverse clinical outcomes including impaired fertilization, disrupted preimplantation embryonic development, increased rates of miscarriage and an enhanced risk of disease in the progeny. The etiology of DNA fragmentation in human spermatozoa is closely correlated with the appearance of oxidative base adducts and evidence of impaired spermiogenesis. We hypothesize that oxidative stress impedes spermiogenesis, resulting in the generation of spermatozoa with poorly remodelled chromatin. These defective cells have a tendency to default to an apoptotic pathway associated with motility loss, caspase activation, phosphatidylserine exteriorization and the activation of free radical generation by the mitochondria. The latter induces lipid peroxidation and oxidative DNA damage, which then leads to DNA fragmentation and cell death. The physical architecture of spermatozoa prevents any nucleases activated as a result of this apoptotic process from gaining access to the nuclear DNA and inducing its fragmentation. It is for this reason that a majority of the DNA damage encountered in human spermatozoa seems to be oxidative. Given the important role that oxidative stress seems to have in the etiology of DNA damage, there should be an important role for antioxidants in the treatment of this condition. If oxidative DNA damage in spermatozoa is providing a sensitive readout of systemic oxidative stress, the implications of these findings could stretch beyond our immediate goal of trying to minimize DNA damage in spermatozoa as a prelude to assisted conception therapy.

show abstract

Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa

Cited by 88 publications

References 16 publications

Role of melatonin on calcium signaling and mitochondrial oxidativestress in epilepsy: focus on TRP channels

Role of melatonin on calcium signaling and mitochondrial oxidativestress in epilepsy: focus on TRP channels

Oxytocin in The Prevention of Injury Due to Testicular Torsion/Detorsion in Rats

Apoptosis and DNA damage in human spermatozoa

Contact Info

Product

Resources

About