Melatonin as a potential inhibitor of colorectal cancer: Molecular mechanisms

Shafabakhsh, Rana; Reíter, Russel J.; Davoodabadi, Abdoulhossein; Asemi, Zatollah

doi:10.1002/jcb.28833

Cited by 9 publications

(8 citation statements)

References 96 publications

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“…Melatonin, a derivative of tryptophan, is a neurohormone initially isolated from the bovine pineal gland 1 that is widely distributed in body tissues including the gastrointestinal tract 2,3 . Melatonin is involved in various physiological functions such as antioxidation, anti‐inflammation, and immunomodulation 4–6 .…”

Section: Introductionmentioning

confidence: 99%

Dietary melatonin and liver cancer incidence in Japan: From the Takayama study

Wada,

Hattori,

Maruyama

et al. 2024

Cancer Science

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There is some biological plausibility that exogenous melatonin plays a role in preventing liver carcinogenesis. There has been little research on the association between melatonin intake in a normal diet and health outcomes. We evaluated the association between dietary melatonin intake and the incidence of liver cancer in a population‐based prospective study in Japan. This study included 30,824 residents of Takayama city who were 35 years of age or older in 1992 and had participated in the Takayama study, Japan. Dietary intake was assessed using a validated food frequency questionnaire at the baseline. Melatonin content in foods was measured by liquid chromatography–tandem mass spectrometry. Cancer incidence was confirmed through regional population‐based cancer registries in Gifu. Liver cancer was defined as code C22 according to the International Classification of Diseases and Related Health Problems, 10th Revision. Hazard ratios for liver cancer were estimated for the tertile groups of melatonin intake using a Cox proportional hazards model. During the mean follow‐up period of 13.6 years, 189 individuals developed liver cancer. Compared with subjects in the lowest tertile of melatonin intake, those in the middle and highest tertiles had decreased risks of liver cancer, with a significant linear trend after multivariate adjustments (hazard ratios: 0.64 and 0.65, respectively, trend p = 0.023). There was no significant interaction by sex (interaction p = 0.54). This initial finding, which needs to be confirmed by further studies, suggests that consuming melatonin‐containing foods might play a role in the prevention of liver cancer.

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Section: Introductionmentioning

confidence: 99%

Dietary melatonin and liver cancer incidence in Japan: From the Takayama study

Wada,

Hattori,

Maruyama

et al. 2024

Cancer Science

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“…The lack of norepinephrine-mediated stimulation during the day results in the suppression of melatonin levels by the rapid proteolytic decomposition of AANAT. Indeed, melatonin is synthesized by tissues other than the pineal gland, such as the retina [ 15 ], skin [ 16 ], gastrointestinal tract [ 17 ], thymus [ 18 ], lymphocytes [ 19 , 20 ], and bone marrow [ 21 ], with this synthesis modulated by paracrine or autocrine mechanisms rather than the circadian cycle [ 22 ]. Based on its ubiquitous distribution in animal cells and organs, it is not surprising that melatonin triggers various functions through many molecular pathways.…”

Section: Introductionmentioning

confidence: 99%

Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis

Sun

2022

Antioxidants

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Bovine mastitis is a common inflammatory disease, mainly induced by bacterial pathogens, such as Staphylococcus aureus, Escherichia coli, and Streptococcus agalactiae. Mastitis has negative effects on the production and quality of milk, resulting in huge economic losses. Melatonin, which is synthesized and secreted by the pineal gland and other organs, is ubiquitous throughout nature and has different effects on different tissues. Melatonin is crucial in modulating oxidative stress, immune responses, and cell autophagy and apoptosis, via receptor-mediated or receptor-independent signaling pathways. The potent antioxidative and anti-inflammatory activities of melatonin and its metabolites suggest that melatonin can be used to treat various infections. This article reviews the potential for melatonin to alleviate bovine mastitis through its pleiotropic effect on reducing oxidative stress, inhibiting pro-inflammatory cytokines, and regulating the activation of NF-κB, STATs, and their cascade reactions. Therefore, it is promising that melatonin supplementation may be an alternative to antibiotics for the treatment of bovine mastitis.

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“…Melatonin can be produced by diverse tissues including pineal gland, GI tract, testes, retina, and lymphocytes ( 10 ). Melatonin receptors are G-protein coupled receptors, which can be divided into melatonin receptor 1 (MT1) and melatonin receptor 2 (MT2) according to their different affinity ( 11 ).…”

Section: Introductionmentioning

confidence: 99%

The mechanisms and roles of melatonin in gastrointestinal cancer

et al. 2022

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Gastrointestinal (GI) cancer is a global health problem with wide lesions and numerous cases. The increased morbidity and mortality of GI cancer is a socio-economic challenge for decades to come. Melatonin, a nature indolamine, exerts a crucial role in molecular interactions involved in multiple functional and physiological processes. Increasing evidence indicates that melatonin can modulate GI tract, decrease the occurrence of GI cancer, and enhance the sensitivity to chemoradiotherapy. However, little is known about the exact role of melatonin in anti-carcinogenesis. In this review, we discuss the action of the beneficial effects of melatonin in GI carcinogenesis. Furthermore, we compile the understanding of the role of melatonin in GI cancer, including esophageal cancer (EC), gastric cancer (GC), hepatocellular carcinoma (HCC), colorectal cancer (CRC), and pancreatic cancer (PC). In addition, the potential therapeutic application and clinical evaluation of melatonin in GI cancer are also discussed.

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Melatonin as a potential inhibitor of colorectal cancer: Molecular mechanisms

Cited by 9 publications

References 96 publications

Dietary melatonin and liver cancer incidence in Japan: From the Takayama study

Dietary melatonin and liver cancer incidence in Japan: From the Takayama study

Insight of Melatonin: The Potential of Melatonin to Treat Bacteria-Induced Mastitis

The mechanisms and roles of melatonin in gastrointestinal cancer

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