Melatonin as a marker of severity of cardiac disorders in developing cachexia syndrome among cancer patients of different age groups

Biomarkers and mechanisms associated with cancer‐induced cardiac cachexia: A systematic review

“…Those with pre-cachexia and cachexia had the most cardiac findings such as high-grade premature ventricular contractions (PVCs), hypertension and either new or progressive chest pain secondary to coronary artery disease. 19 Melatonin Endogenous melatonin excretion was greatly reduced in patients with cancer and cancer-associated cachexia, who developed cardiac dysfunction. 19 The decrease in melatonin production, measured by urine 6-sulfatoxymelatonin (aMT6s), 19 became more pronounced (P < 0.05) in pre-cachectic and cachectic subjects.…”

“…19 Melatonin Endogenous melatonin excretion was greatly reduced in patients with cancer and cancer-associated cachexia, who developed cardiac dysfunction. 19 The decrease in melatonin production, measured by urine 6-sulfatoxymelatonin (aMT6s), 19 became more pronounced (P < 0.05) in pre-cachectic and cachectic subjects. This effect was even greater in individuals 60 years and older.…”

“…Cardiac symptoms associated with cachexia status Cardiovascular symptoms indicated cachexia status in one human study. 19 A total of 103 subjects (male:female = 11:92) with newly diagnosed stages of II-IV malignancies were classified as non-cachectic, pre-cachectic or cachectic in this study. 19 Non-cachectic cancer patients showed the least number of cardiovascular symptoms.…”

“…19 A total of 103 subjects (male:female = 11:92) with newly diagnosed stages of II-IV malignancies were classified as non-cachectic, pre-cachectic or cachectic in this study. 19 Non-cachectic cancer patients showed the least number of cardiovascular symptoms. Those with pre-cachexia and cachexia had the most cardiac findings such as high-grade premature ventricular contractions (PVCs), hypertension and either new or progressive chest pain secondary to coronary artery disease.…”