Melatonin and prolonged physical activity attenuated the detrimental effects of diabetic condition on murine cardiac tissue

Rahbarghazi, Afshin; Siahkouhian, Marefat; Rahbarghazi‬, Reza; Ahmadi, Mahdi; Bolboli, Lotfali; Mahdipour, Mahdi; Haghighi, Ladan; Hassanpour, Mehdi; Nasimi, Fatemeh Sokouti; Keyhanmanesh, ‬Rana

doi:10.1016/j.tice.2021.101486

Cited by 8 publications

(13 citation statements)

References 55 publications

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“…These studies indicated that Mel can significantly induce the activity of SOD in diabetic rats (Standardized mean difference (SMD): 3.229 CI 95%, 0.164 to 6.294; p = 0.039; I 2 = 95.29%) (Fig. 2 A) [ 4 , 17 , 23 , 24 ]. Two experiments (n = 78; 18 Mel-treated DM and 18 DM) studied the effect of Mel on glutathione under diabetic conditions.…”

Section: Resultsmentioning

confidence: 99%

“…The analysis results showed SMD of GPx was 4.834 (CI 95%, mean difference: 0.105 to 9.563; p = 0.045; Fig. 2 C) [ 9 , 17 , 24 ]. Other 4 experiments (n = 226; 59 Mel + DM and 59 DM) released data associated with the impact of Mel on malondialdehyde (MDA) under diabetic conditions.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the random model was applied and the results showed that SMD of MDA reached − 0.487 (CI 95%, mean difference: − 3.810 to 2.836; p < 0.774) (Fig. 2 D and Table 3 ) [ 4 , 17 , 23 , 26 ].

Fig.…”

Section: Resultsmentioning

confidence: 99%

“…Regarding the existence of physical and chemical activities, Mel with specific properties can be used in the management of DM [ 15 , 16 ]. The modulation of inflammation and inhibition of apoptosis is the underlying mechanisms by which Mel protects cardiomyocytes against diabetic conditions [ 17 ]. Direct diffusion and internalization via cell-membrane bound receptors help Mel to actively neutralize cellular free radicals [ 18 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Co-administration of exercise training and melatonin on the function of diabetic heart tissue: a systematic review and meta-analysis of rodent models

Rahbarghazi

Alamdari

Rahbarghazi‬

et al. 2023

Diabetol Metab Syndr

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Purpose Diabetes mellitus (DM), a hyperglycemic condition, occurs due to the failure of insulin secretion and resistance. This study investigated the combined effects of exercise training and melatonin (Mel) on the function of heart tissue in diabetic rodent models. Methods A systematic search was conducted in Embase, ProQuest, Cochrane library, Clinicaltrial.gov, WHO, Google Scholar, PubMed, Ovid, Scopus, Web of Science, Ongoing Trials Registers, and Conference Proceedings in July 2022 with no limit of date or language. All trials associated with the effect of Mel and exercise in diabetic rodent models were included. Of the 962 relevant publications, 58 studies met our inclusion criteria as follows; Mel and type 1 DM (16 studies), Mel and type 2 DM (6 studies), exercise and type 1 DM (24 studies), and exercise and type 2 DM (12 studies). Meta-analysis of the data was done using the Mantel Haenszel method. Results In most of these studies, antioxidant status and oxidative stress, inflammatory response, apoptosis rate, lipid profiles, and glucose levels were monitored in diabetic heart tissue. According to our findings, both Mel and exercise can improve antioxidant capacity by activating antioxidant enzymes compared to the control diabetic groups (p < 0.05). The levels of pro-inflammatory cytokines, especially TNF-α were reduced in diabetic rodents after being treated with Mel and exercise. Apoptotic changes were diminished in diabetic rodents subjected to the Mel regime and exercise in which p53 levels and the activity of Caspases reached near normal levels (p < 0.05). Based on the data, both Mel and exercise can change the lipid profile in diabetic rodents, especially rats, and close it to near-to-control levels. Conclusion These data showed that exercise and Mel can reduce the harmful effects of diabetic conditions on the heart through the regulation of lipid profile, antioxidant capacity, apoptosis, and inflammation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Fig.…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Co-administration of exercise training and melatonin on the function of diabetic heart tissue: a systematic review and meta-analysis of rodent models

Rahbarghazi

Alamdari

Rahbarghazi‬

et al. 2023

Diabetol Metab Syndr

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“…The overall global incidence of diabetes is predicted to increase from 451 million (age 18-99 years) in 2017 to 693 million by 2035 (Cho et al, 2018). It is usually accompanied by serious complications, especially those associated with the cardiovascular system, such as diabetic cardiomyopathy (DCM) (Ling et al, 2020;Rahbarghazi et al, 2021), which is one of the leading causes of death in individuals with type 2 diabetes (Brown et al, 2010). DCM is characterized by fibrosis, with functional and pathological damage to the myocardium.…”

Section: Introductionmentioning

confidence: 99%

Hyperglycemia-induced myocardial fibrosis may be associated with pyroptosis and apoptosis of cardiomyoctes in diabetic mice

Lu¹,

WANG²,

ZHANG³

2023

Biocell

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Myocardial fibrosis is an important manifestation of diabetic cardiomyopathy. This study investigated the potential mechanism of diabetic myocardial fibrosis. Male C57BL/6J and db/db mice aged 8 weeks were randomly divided into the diabetic (DB) and control groups. At 20 weeks, the mouse heart was harvested and subjected to hematoxylin-eosin staining (HE) and Masson staining to investigate the degree of fibrosis. The expressions of transforming growth factor-beta 1 (TGF-β1), collagen-III, B-cell lymphoma-2 (Bcl2), Bcl2-associated X protein (Bax), cleaved gasdermin D (GSDMD), cysteinyl aspartate specific proteinase-1 (caspase-1), apoptosis-associated speck-like protein containing a CARD (ASC), and nucleotide-binding oligomerization domain (NOD)-like receptor 3 (NLRP3) were measured by western blotting. Immunohistochemistry and TdT-mediated dUTP nick end labeling (TUNEL) staining were performed to analyze the development of apoptosis and pyroptosis. A significant increase in body weight and blood glucose in the DB group was observed. Myocardial pathological injury, fibrosis, apoptosis, and pyroptosis were more obvious and serious in the DB group. The expression of anti-apoptotic Bcl2 significantly decreased, while the expression levels of pro-apoptotic Bax, caspase-3, and pyroptosis-related proteins, such as cleaved GSDMD, and caspase-1 in the DB group were significantly increased. Pyroptosis and apoptosis were probably the main mechanisms that caused myocardial fibrosis in mice with diabetes.

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Putative effect of melatonin on cardiomyocyte senescence in mice with type 1 diabetes mellitus

Rahbarghazi‬

Farhoudi

Rahmani-Youshanlouei

et al. 2022

J Diabetes Metab Disord

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Melatonin and prolonged physical activity attenuated the detrimental effects of diabetic condition on murine cardiac tissue

Cited by 8 publications

References 55 publications

Co-administration of exercise training and melatonin on the function of diabetic heart tissue: a systematic review and meta-analysis of rodent models

Co-administration of exercise training and melatonin on the function of diabetic heart tissue: a systematic review and meta-analysis of rodent models

Hyperglycemia-induced myocardial fibrosis may be associated with pyroptosis and apoptosis of cardiomyoctes in diabetic mice

Putative effect of melatonin on cardiomyocyte senescence in mice with type 1 diabetes mellitus

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