Melatonin and pineal neurochemicals in steers grazed on endophyte-infected tall fescue: effects of metoclopramide1

Jk, Porter; Ja, Stuedemann; Fn, Thompson; Ba, Buchanan; Tucker, H.A.

doi:10.2527/1993.7161526x

Cited by 13 publications

(4 citation statements)

References 27 publications

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“…For example, while melatonin was not directly measured, metabolites derived from it were increased in the urine (i.e., AFMK) and decreased in the plasma. Decreased plasma melatonin in E+, which would be consistent with the findings here, has been reported (Porter et al, 1993). AFMK is the product of the reaction between melatonin and reactive oxygen species (ROS; de Almeida et al, 2003;Hardeland et al, 1995;Tan et al, 2000), and previous reports found widespread decreased antioxidant defense mechanisms due to E+ (Lakritz et al, 2002;Settivari et al, 2008;Zbib et al, 2014Zbib et al, , 2015.…”

Section: Accepted Manuscriptsupporting

confidence: 92%

Metabolomics of fescue toxicosis in grazing beef steers

Mote

Hill

Uppal

et al. 2017

Food and Chemical Toxicology

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Fescue toxicosis (FT) results from consumption of tall fescue (Lolium arundinaceum) infected with an endophyte (Epichloë coenophiala) that produces ergot alkaloids (EA), which are considered key etiological agents of FT. Decreased weight gains, hormonal imbalance, circulating cholesterol disruption, and decreased volatile fatty acid absorption suggest toxic (E+) fescue-induced metabolic perturbations. Employing untargeted high-resolution metabolomics (HRM) to analyze E+ grazing-induced plasma and urine metabolome changes, fescue-naïve Angus steers were placed on E+ or non-toxic (Max-Q) fescue pastures and plasma and urine were sampled before, 1, 2, 14, and 28 days after pasture assignment. Plasma and urine catecholamines and urinary EA concentrations were also measured. In E+ steers, urinary EA appeared early and peaked at 14 days. 13,090 urinary and 20,908 plasma HRM features were detected; the most significant effects were observed earlier (2 days) in the urine and later (≥14 days) in the plasma. Alongside EA metabolite detection, tryptophan and lipid metabolism disruption were among the main consequences of E+ consumption. The E+ grazing-associated metabolic pathways and signatures described herein may accelerate development of novel early FT detection and treatment strategies.

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Section: Accepted Manuscriptsupporting

confidence: 92%

Metabolomics of fescue toxicosis in grazing beef steers

Mote

Hill

Uppal

et al. 2017

Food and Chemical Toxicology

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“…A retrospective analysis of nine previously reported datasets revealed daylength was positively correlated with E. coli prevalence . Steers grazing endophyte-infected tall fescue had decreased plasma concentrations of melatonin (Porter et al, 1993). Recently, Edrington et al (2007) reported fecal shedding of E. coli O157:H7 from naturally infected steers was decreased in steers receiving melatonin.…”

Section: Discussionmentioning

confidence: 98%

Effects of the Ergot Alkaloids Dihydroergotamine, Ergonovine, and Ergotamine on Growth ofEscherichia coliO157:H7In Vitro

Looper

Edrington

Moubarak

et al. 2008

Foodborne Pathogens and Disease

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A series of experiments were conducted to evaluate the effects of ergot alkaloids (dihydroergotamine, ergonovine, and ergotamine) on E. coli O157:H7 in both pure and mixed ruminal fluid culture. Alkaloids were added to solutions of E. coli O157:H7 strains 933 (pure and ruminal cultures) and 6058 (ruminal culture only), and growth rates and colony-forming units (CFU) of E. coli O157:H7 were measured. Two mixtures of all three alkaloids at either 2 or 500 microM for each alkaloid decreased (p < 0.001) the growth rate of E. coli O157:H7 in pure culture compared to the individual alkaloids. Dihydroergotamine tended (p = 0.07) to reduce growth rate of E. coli O157:H7 in pure culture compared with ergonovine or ergotamine alone. Increased concentrations of dihydroergotamine and ergotamine decreased (p < 0.003) growth rate of E. coli O157:H7 but increasing concentrations of ergonovine did not influence (p > 0.10) E. coli O157:H7 growth rate. Similar to results in pure culture, a mixture of all three alkaloids at various concentrations for each alkaloid decreased (p < 0.001) the CFU of E. coli O157:H7 strain 6058 in mixed ruminal culture compared to the individual ergot alkaloids. Dihydroergotamine decreased (p = 0.04) CFU of E. coli O157:H7 strain 6058 when compared to ergonovine but CFU were similar (p > 0.10) between dihydroergotamine and ergotamine. Ruminal and (or) intestinal populations of E. coli O157:H7 may be influenced in livestock consuming endophyte-infected tall fescue, and these alterations could be due to the presence of ergot alkaloids in fescue plants.

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“…Maternal hyperthermia in pregnant mice has been shown to increase embryonic death via an increase in oxidative stress, while melatonin injections alleviated this effect by maintaining a neutral redox status [ 57 ]. Cattle grazing endophyte-infected fescue exhibit decreased plasma melatonin [ 58 , 59 ], rough hair coats, and vasoconstriction to peripheral tissues, limiting heat dissipation and increasing body temperature [ 50 , 60 ]. Based on these findings, it is suggested to further investigate the role of melatonin and its usage as a therapeutic in domesticated farm animals experiencing cardiovascular diseases and hyperthermia.…”

Section: Circadian Rhythms Environmental Factors and Body Temperaturementioning

confidence: 99%

Melatonin in Health and Disease: A Perspective for Livestock Production

et al. 2023

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Mounting evidence in the literature indicates an important role of endogenous and exogenous melatonin in driving physiological and molecular adaptations in livestock. Melatonin has been extensively studied in seasonally polyestrous animals whereby supplementation studies have been used to adjust circannual rhythms in herds of animals under abnormal photoperiodic conditions. Livestock undergo multiple metabolic and physiological adaptation processes throughout their production cycle which can result in decreased immune response leading to chronic illness, weight loss, or decreased production efficiency; however, melatonin’s antioxidant capacity and immunostimulatory properties could alleviate these effects. The cardiovascular system responds to melatonin and depending on receptor type and localization, melatonin can vasodilate or vasoconstrict several systemic arteries, thereby controlling whole animal nutrient partitioning via vascular resistance. Increased incidences of non-communicable diseases in populations exposed to circadian disruption have uncovered novel pathways of neurohormones, such as melatonin, influence health, and disease. Perturbations in immune function can negatively impact the growth and development of livestock which has been examined following melatonin supplementation. Specifically, melatonin can influence nutrient uptake, circulating nutrient profiles, and endocrine profiles controlling economically important livestock growth and development. This review focuses on the physiological, cellular, and molecular implications of melatonin on the health and disease of domesticated food animals.

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Melatonin and pineal neurochemicals in steers grazed on endophyte-infected tall fescue: effects of metoclopramide1

Cited by 13 publications

References 27 publications

Metabolomics of fescue toxicosis in grazing beef steers

Metabolomics of fescue toxicosis in grazing beef steers

Effects of the Ergot Alkaloids Dihydroergotamine, Ergonovine, and Ergotamine on Growth ofEscherichia coliO157:H7In Vitro

Melatonin in Health and Disease: A Perspective for Livestock Production

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