Melatonin and male reproduction

Li, Chunjin; Zhou, Xu

doi:10.1016/j.cca.2015.04.029

Cited by 79 publications

(41 citation statements)

References 78 publications

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“…Enrichment was also found in pathways that, to our knowledge have not been associated previously with the key-pathophysiological signs of MPB such as melatonin signalling/degradation, adipogenesis and immune related pathways. Notably, both melatonin degradation and adipogenesis are reported to interact with, and to be controlled by, sex hormones3738 and decreasing melatonin levels are a potential marker of puberty progression39. These findings highlight the indispensability of sex hormones to the MPB phenotype40, and point to a novel potential link between intrafollicular melatonin synthesis and its recognized effects on oestrogen receptor expression and thus the sensitivity of human scalp hair follicles to stimulation with oestrogens, which effectively counteract the anagen-shortening effects of DHT in MPB development3641.…”

Section: Resultsmentioning

confidence: 99%

Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness

et al. 2017

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Male-pattern baldness (MPB) is a common and highly heritable trait characterized by androgen-dependent, progressive hair loss from the scalp. Here, we carry out the largest GWAS meta-analysis of MPB to date, comprising 10,846 early-onset cases and 11,672 controls from eight independent cohorts. We identify 63 MPB-associated loci (P<5 × 10−8, METAL) of which 23 have not been reported previously. The 63 loci explain ∼39% of the phenotypic variance in MPB and highlight several plausible candidate genes (FGF5, IRF4, DKK2) and pathways (melatonin signalling, adipogenesis) that are likely to be implicated in the key-pathophysiological features of MPB and may represent promising targets for the development of novel therapeutic options. The data provide molecular evidence that rather than being an isolated trait, MPB shares a substantial biological basis with numerous other human phenotypes and may deserve evaluation as an early prognostic marker, for example, for prostate cancer, sudden cardiac arrest and neurodegenerative disorders.

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Section: Resultsmentioning

confidence: 99%

Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness

et al. 2017

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“…Melatonin is a powerful antioxidant and antiapoptotic agent synthesised from the essential amino acid L‐tryptophan; moreover, a growing body of evidence indicates that melatonin has important effects in the reproduction of nonseasonal breeding animals (Li & Zhou, ). In males, melatonin affects reproductive regulation in three main ways.…”

Section: Discussionmentioning

confidence: 99%

Melatonin therapy adds extra benefit to varicecelectomy in terms of sperm parameters, hormonal profile and total antioxidant capacity: A placebo-controlled, double-blind trial

Liu²,

et al. 2018

Andrologia

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In this study, we aimed at investigating the impact of melatonin supplementation on semen parameters, hormonal profile and total antioxidant capacity after varicocelectomy. Infertile male patients who were diagnosed with varicocele and underwent subinguinal varicocelectomy were included in the study. After performing subinguinal varicocelectomy, the patients were randomised into two groups: 27 receiving melatonin for 3 months and 27 as the placebo-controlled group receiving placebo for 3 months. The pre-operative parameters of semen analyses, hormonal profile and seminal oxidative stress status of both groups were compared with those of post-operative parameters. There were statistically significant improvements in post-operative parameters of semen analyses (sperm concentration, motility and proportions of normally formed spermatozoa), peripheral blood inhibin B and total antioxidant capacity in melatonin group compared with placebo group. In conclusion, melatonin therapy adds extra benefit to varicecelectomy in terms of sperm parameters, peripheral blood inhibin B and total antioxidant capacity; however, further studies including large number of samples are needed to make a proper decision on melatonin supplementation after varicocelectomy.

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“…Furthermore, melatonin treatment alleviates ERS during bleomycin-induced pulmonary fibrosis [25]. Melatonin affects the regulation of testicular development and male reproduction by stimulating the secretion of gonadotropins and testosterone [26]. It also prevents cisplatin-induced primordial follicle loss [27].…”

Section: Introductionmentioning

confidence: 99%

Melatonin Relieves Busulfan-Induced Spermatogonial Stem Cell Apoptosis of Mouse Testis by Inhibiting Endoplasmic Reticulum Stress

Cui

Ren

et al. 2017

Cell Physiol Biochem

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Background/Aims: Busulfan is commonly used for cancer chemotherapy. Although it has the advantage of increasing the survival rate of patients, it can cause male infertility via damaging the testes and reducing sperm counts. Therefore, the underlying mechanism should be explored, and new agents should be developed to protect the male reproductive system from busulfan-induced damage. Endoplasmic reticulum stress (ERS) is considered a key contributor to numerous pathologies. Despite several studies linking ERS to toxicants, studies have yet to determine whether ERS is a contributing factor to busulfan-induced testicular damage. Melatonin is a well-known broad-spectrum antioxidant, anti-inflammatory and antitumour agent, but the effects of melatonin on busulfan-induced ERS in mouse testes damage are less documented. Methods: The effects of melatonin were measured by immunofluorescence staining, Western blot, qRT-PCR analysis and flow cytometry assay. The underlying mechanism was investigated by measuring ERS. Results: We found that ERS was strongly activated in mouse testes (in vivo) and the C18-4 cell line (in vitro) after busulfan administration. ERS-related apoptosis proteins such as caspase-12, CHOP and caspase-3 were activated, and the expression of apoptotic proteins such as P53 and PUMA were upregulated. Furthermore, we investigated whether melatonin reduced the extent of damage to mouse testes and improved the survival rates of busulfan-treated mice. When exploring the underlying mechanisms, we found melatonin could counteract ERS by decreasing the expression levels of the ERS markers GRP78, ATF6, pIRE1 and XBP1 in mouse testes and mouse SSCs (C18-4 cells). Moreover, it blocked the activation of ERS-related apoptosis proteins caspase-12, CHOP and caspase-3 and suppressed P53 and PUMA expression stimulated by busulfan both in vivo and in vitro. Conclusion: Our results demonstrate that ERS is an important mediator for busulfan-induced apoptosis. The attenuation of ERS by melatonin can prevent busulfan-treated SSCs apoptosis and protect busulfan-treated testes from damage. Thus, this study suggests that melatonin may alleviate the side effects of busulfan for male patients during clinical treatment.

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Melatonin and male reproduction

Cited by 79 publications

References 78 publications

Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness

Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness

Melatonin therapy adds extra benefit to varicecelectomy in terms of sperm parameters, hormonal profile and total antioxidant capacity: A placebo-controlled, double-blind trial

Melatonin Relieves Busulfan-Induced Spermatogonial Stem Cell Apoptosis of Mouse Testis by Inhibiting Endoplasmic Reticulum Stress

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