Melatonin and human skin aging

Kleszczyński, Konrad; Fischer, Tobias W.

doi:10.4161/derm.22344

Cited by 65 publications

(68 citation statements)

References 80 publications

(144 reference statements)

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“…Moreover, melatonin [34], vitamin C, and beta-glucan increase its antioxidant, immunomodulant, and protective effectiveness, as reported by our previous studies [51][52][53][54].…”

Section: In Vitrosupporting

confidence: 60%

“…Melatonin, which is able to counteract oxidative stress and suppress damaged cells' proliferation, has been shown to provide cellular protection against UVR damage when topically applied [34]. Moreover, all the other ingredients used to make the non-woven tissue of the beauty mask, such as CN, LG, Chitosan, Polyethylene Oxide (PEOX), and the polypeptides, contributed to reinforce the anti-inflammatory, immunomodulating, and re-epithelialisation activity of the active ingredients selected, as reported in our previous studies [17][18][19][20][21].…”

mentioning

confidence: 99%

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Green Nanotechnology Serving the Bioeconomy: Natural Beauty Masks to Save the Environment

Morganti

Palombo

Carezzi³

et al. 2016

Cosmetics

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According to United Nations Environment Programme (UNEP), ensuring a clean and healthy environment will provide multiple benefits to society and economy. Sustainable production, followed by appropriate management of industrial and agricultural waste, will protect and enhance biodiversity and ecosystem services. To achieve this objective, specific policies must be put in place and specific actions performed for making a low-carbon and resource-efficient economy with reduced production of petrol-derived goods. The aim of the study has been to produce effective and safe anti-age beauty masks made of non-woven tissues based on the use of chitin nanofibril (CN) and nanolignin (LG), obtained from crustaceans and plant biomass, respectively. To this purpose, nanoparticles and electrospun fibres have been characterized by Dynamic Light Scattering and SEM, while the safeness and effectiveness of the obtained tissues was verified in vitro on a culture of keratinocytes and fibroblasts, and controlled in vivo by expert dermatologists on 30 volunteer photo-aged women, by subjective and objective bioengineered methods. The in vitro results have shown that the beauty masks have no toxic effects on the viability of keratinocytes and fibroblasts treated by the Dimethyl Tetrazole (MTT) method, and exhibit a decreased expression of cytokines, playing a central role in the regulation of immune and inflammatory responses in premature aging and environmental assaults. The reparative and antiaging effectiveness of these innovative beauty masks have been also verified on the release of Metallo Proteinase I (MMP-1) and the increased synthesis of collagen type I, reduced in skin aging. The first preliminary in vivo results, obtained by engineering methods, have confirmed the protective and rejuvenating activity shown by the in vitro study conducted on 30 voluntary women exhibiting signs of photoaging. The raw materials used are of natural origin being also respectful of the environment, according to the Organization for Economic Cooperation and Development (EOCD) and EU programmes.

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“…Moreover, melatonin [34], vitamin C, and beta-glucan increase its antioxidant, immunomodulant, and protective effectiveness, as reported by our previous studies [51][52][53][54].…”

Section: In Vitrosupporting

confidence: 60%

mentioning

confidence: 99%

Green Nanotechnology Serving the Bioeconomy: Natural Beauty Masks to Save the Environment

Morganti

Palombo

Carezzi³

et al. 2016

Cosmetics

View full text Add to dashboard Cite

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“…In skin, melatonin can be synthesized by normal and malignant keratinocytes (stratum corneum), melanocytes (epidermis) and fibroblasts (dermis). This synthesis may be induced or modified by UVB irradiation (Kleszczynski & Fischer, 2012;Rezzani et al, 2014;Kim et al, 2015a). Melatonin receptors are G protein-coupled receptors, and there are two subtypes in humans (MT 1 , MT 2 ).…”

Section: Introductionmentioning

confidence: 99%

“…By activating cytoprotective pathways, counteracting oxidative stress and suppressing the damaged cells proliferation, melatonin has been shown to provide cellular protection against UVR damage. In fact, numerous studies have recognized the photoprotective effects of melatonin after topical application (Reiter et al, 1997;Slominski et al, 2005b;Kleszczynski & Fischer, 2012), including reduction of UV-induced erythema, protection against oxidative damage caused by UVA rays and prevention of both photoageing and photocarcinogenesis (Papagiannidou et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Melatonin-based pickering emulsion for skin's photoprotection

et al. 2016

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Context: Based on its antioxidant activity, melatonin was recently found to have a protection effect against photocarcinogenesis. Objective: This work aimed to develop an innovative sunscreen formulation based on the Pickering emulsions concept, stabilized by physical UV filters, modified starch and natural oils associated to melatonin as a key strategy for prevention against UV-induced skin damage. Materials and methods: For this purpose, melatonin was incorporated in Pickering emulsions that were characterized using physicochemical, in vitro and in vivo testing. Physicochemical studies included physical and chemical stability by a thorough pharmaceutical control. The possible protective effects of melatonin against UV-induced cell damage in HaCaT cell lines were investigated in vitro. The safety assessment and the in vivo biological properties of the final formulations, including Human Repeat Insult Patch Test and sunscreen water resistance tests were also evaluated. Results and discussion: These studies demonstrated that melatonin sunscreen Pickering emulsion was beneficial and presented a powerful protection against UVB-induced damage in HaCat cells, including inhibition of apoptosis. The inclusion of zinc oxide, titanium dioxide, green coffee oil and starch ensured a high SPF (50+) against UVA and UVB. Conclusion: The combination of melatonin, multifunctional solid particles and green coffee oil, contributed to achieve a stable, effective and innovative sunscreen with a meaningful synergistic protection against oxidative stress.

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“…This system includes the epidermis, dermis and hair follicles. It is likely that the MAS has evolved as a result of the defense mechanisms against environmental factors, in particular UV radiation [3,[10][11][12][13][14][15]. The antioxidant activity of melatonin is mediated by binding to nuclear receptors ROR/RZR and stimulation of gene expression of the main antioxidant enzymes (catalase, glutathione peroxidase).…”

Section: Melatonin Functions In the Skinmentioning

confidence: 99%

The role of melatonin in the light of current knowledge

Algiert¹,

Rotsztejn²,

Mucha³

et al. 2016

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Recent studies have shed new light on the role of melatonin. Local tissue synthesis has been investigated. A special system responsible for the synthesis and metabolism of melatonin has developed in the human skin. The primary role of melatonin is the regulation of circadian rhythms, but studies have demonstrated the diversity of its activities. Potent antioxidant action of melatonin in the skin is emphasized. The skin has developed a specific antioxidant melatoninergic system which protects against oxidative stress. Presence of melatonin metabolites in the skin confirms its strong antioxidant properties. Melatonin has the ability to restore the physiological balance between synthesis and degradation of extracellular matrix proteins by induction of heme oxygenase in murine fibroblasts irradiated with UVR. There is a hypothesis concerning the participation of melatonin in etiology of vitiligo. Disturbances of melatonin skin synthesis and dysregulation of its receptors may explain the pathogenesis of disease. streszczenie Prowadzone w ostatnich latach badania rzucają nowe światło na rolę melatoniny. Wskazuje się na jej lokalną i tkankową syntezę. W skórze rozwinął się specjalny system, który odpowiada za syntezę oraz metabolizm melatoniny. Podstawową rolą melatoniny jest regulacja rytmu dobowego, jednak liczne badania wykazały różnorodność jej działania. Podkreśla się silne działanie antyoksydacyjne melatoniny w skórze, która rozwinęła specyficzny antyoksydacyjny system melatoninergiczny chroniący przed stresem oksydacyjnym. Obecność metabolitów melatoniny w skórze dodatkowo potwierdza jej silne właściwości antyoksydacyjne. Melatonina ma zdolność do przywracania równo-wagi fizjologicznej pomiędzy syntezą a rozpadem protein macierzy zewnątrzkomórkowej przez indukcję oksygenazy hemowej w mysich fibroblastach naświetlanych promieniowaniem UV. Istnieje hipoteza dotycząca udziału melatoniny w bielactwie nabytym, według której zaburzenia jej skórnej syntezy i rozregulowanie jej receptorów mogą tłumaczyć patogenezę tej choroby.the role of melatonin in the light of current knowledge znaczenie melatoniny w świetle obecnej wiedzy

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Melatonin and human skin aging

Cited by 65 publications

References 80 publications

Green Nanotechnology Serving the Bioeconomy: Natural Beauty Masks to Save the Environment

Green Nanotechnology Serving the Bioeconomy: Natural Beauty Masks to Save the Environment

Melatonin-based pickering emulsion for skin's photoprotection

The role of melatonin in the light of current knowledge

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