Melatonin and dopamine serum level associations with motor, cognitive, and sleep dysfunctions in patients with Parkinson’s disease: A cross-sectional research study

Editorial: Advances in rehabilitation for motor symptoms in neurodegenerative disease

“…Blight therapy also improves daily physical activity and sleep quality (Videnovic et al, 2017 ). Melatonin administration ameliorates poor sleep quality (Medeiros et al, 2007 ; Hadoush et al, 2020 ) and increases motor activity in patients with PD. Hypothetically, serum melatonin may be a potential biomarker for the effect of rehabilitation on fluctuating motor disability, which is a unique feature of PD.…”

“…In adults with multiple sclerosis, a pilot study showed that acute nocturnal melatonin ingestion was likely to enhance postural balance and physical performance, including the Timed Up and Go test and Timed 25-foot walk test, by improving sleep quality and cognitive function (Jallouli et al, 2022 ). Previous clinical trials on melatonin administration have failed to show its efficacy in treating motor disability (Medeiros et al, 2007 ; Hadoush et al, 2020 ). However, melatonin has been reported to have potential neuroprotective effects, such as free radical scavenging in vitro in cellular models and in vivo in various experimental animal models (Borah and Mohanakumar, 2009 ; Romero et al, 2010 ); additionally, it may block the pro-apoptotic cascade at different levels and prevent neuroinflammation, leading to the prevention of dopaminergic neuronal death.…”

“…However, melatonin has been reported to have potential neuroprotective effects, such as free radical scavenging in vitro in cellular models and in vivo in various experimental animal models (Borah and Mohanakumar, 2009 ; Romero et al, 2010 ); additionally, it may block the pro-apoptotic cascade at different levels and prevent neuroinflammation, leading to the prevention of dopaminergic neuronal death. Although further research is needed to determine whether melatonin directly reduces motor symptoms, the link between motor and non-motor symptoms, including sleep, is intensified in PD; based on the results of many clinical trials, melatonin improves sleep (Medeiros et al, 2007 ; Hadoush et al, 2020 ; Ma et al, 2022 ) and may ameliorate motor disability.…”