Melatonin and Diazepam Affect Anxiety-Like and Depression-Like Behavior in Wistar Rats: Possible Interaction with Central GABA Neurotransmission

Ouakki, Sihame; Mrabet, F.Z.; Lagbouri, Ibtissam; Hessni, Aboubaker El; Mesfioui, Abdelhalem; Pévet, Paul; Challet, Étienne; Ouichou, Ali

doi:10.4236/jbbs.2013.37055

Cited by 8 publications

(5 citation statements)

References 50 publications

(68 reference statements)

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“…In addition, exogenous administration of Mel could ameliorate the depressive-like behavior induced by Ni; this neurohormone significantly reduced immobility time in the FST. Consistent with other reports, it was found that Mel produces a variety of anxiolytic-like effects in different tests [ 24 , 37 , 38 ]. Also, Stefanovic et al showed that Mel elicited a real power antidepressant-like effect in the FST [ 39 ].…”

Section: Discussionsupporting

confidence: 90%

Neuroprotective effect of melatonin on nickel-induced affective and cognitive disorders and oxidative damage in rats

Lamtai

Ouakki

Zghari

et al. 2020

Environ Anal Health Toxicol

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The present work is carried out to explore the neuroprotective potential of Melatonin(Mel), on Ni-induced neurobehavioral, biochemical and histological alterations in male and female rats. The rats were intraperitoneally administered by nickel chloride (NiCl2, 1 mg/kg) and Mel (4 mg/kg) for 60 days. A neurobehavioral assessment was performed. Biochemical determinations of oxidative stress (OS) levels, and histological analysis of hippocampal tissues were also performed. Results showed that Nickel (Ni) treatment increased anxiety-like and depression-like behavior in rats. Besides, cognitive behavior on the Morris water maze was compromised following Ni treatment. Alongside this, Ni elevated hippocampal OS markers like lipid peroxidation and nitric oxide formation with a decrease in superoxide dismutase and catalase activities. Histological observations confirmed these results. Significantly, Mel administration alleviated neurobehavioral changes in Ni-treated rats of both genders. Also, Mel attenuated Ni-induced OS and increased the activities of antioxidant enzymes. The histopathological studies in the hippocampus supported that Mel markedly reduced the Ni-induced neuronal loss. In conclusion, this study suggests that Mel has a neuroprotective effect against Ni-induced neurobehavioral alterations, which may be related to lowering OS in the hippocampus.

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Section: Discussionsupporting

confidence: 90%

Neuroprotective effect of melatonin on nickel-induced affective and cognitive disorders and oxidative damage in rats

Lamtai

Ouakki

Zghari

et al. 2020

Environ Anal Health Toxicol

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“…This sexual dimorphism suggests the involvement of sexual hormones in the modulation of affective disorders by regulating neurotransmitter synthesis release or actions. In this sense, gonadal hormones contribute to the anatomical or functional characteristics of several neurotransmitter systems such as serotoninergic (5-HT) and gabaergic (GABA) systems that regulate anxiety and depression [83] [84] [85]. Edinger and Frye confirmed that sexual experience is associated with lower levels of anxiety-like behaviour and higher levels of androgen secretion [86].…”

Section: Discussionmentioning

confidence: 99%

“…Edinger and Frye confirmed that sexual experience is associated with lower levels of anxiety-like behaviour and higher levels of androgen secretion [86]. It is known that testosterone elevations were associated with reduced male anxiety [83] [84] [85] [87]. Gonadectomy (GDX) in male rats would increase anxiety-like behaviour, an effect which would be reversed by systemic administration of dihydrotestosterone (DHT).…”

Section: Discussionmentioning

confidence: 99%

Effect of Chronic Administration of Cadmium on Anxiety-Like, Depression-Like and Memory Deficits in Male and Female Rats: Possible Involvement of Oxidative Stress Mechanism

Lamtai¹,

Chaibat²,

Ouakki³

et al. 2018

JBBS

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The main objective of this work is to study the effect of chronic administration of cadmium (Cd) on the level of depression-like, anxiety-like, memory state and oxidative stress in male and female Wistar rats. For this purpose, this study was conducted with 24 rats for each gender. Four groups were constituted: (Group 1: Control): received saline solution NaCl (0.9%), (Group 2: Cd-0.25; Group 3: Cd-0.5; Group 4: Cd-1): received daily 0.25 mg/kg, 0.5 mg/kg and 1 mg/kg of Cd respectively during 8 weeks. After treatment period, animals were tested in the open-field, elevated plus maze tests for anxiety-like behavior, and forced swimming test for depression-like behavior. The Y maze was used to evaluate the working memory and the Morris Water Maze, to evaluate space learning and spatial memory. The results revealed that in males, all doses of Cd provoke depression-like, while in females only the group treated with 1 mg/kg Cd shows elevated depression-like behavior. In regard to anxiety-like behavior, Cd induces an anxiogenic effect in both genders tests. In the Y-Maze test, both males and females expressed a low percentage of alternations, suggesting that working memory was affected by Cd at 1 mg/kg. In the Morris Water Maze test, the space learning and spatial memory were significantly impaired in the group Cd-1. Neurochemical analysis showed that levels of nitric oxide and lipid peroxidation in the hippocampus How to cite this paper: Lamtaiwere significantly increased after Cd treatments. Overall analysis of our data revealed that Cd caused significant alterations in the examined parameters that were sex-dependent and dose-dependent. IntroductionCd is one of the most toxic elements that bio-accumulates in the environment [1], especially in industrial areas via atmospheric dispersion and ground contamination surrounding metal emitting industries [2]. Cd may find its way to the human population through food and beverage, drinking water, air, and cigarette smoking. Although its toxicity is well established, the interaction of this element within a biological system and its resulting potential for harm is less well established. Cd has a long biological half-life mainly due to its low rate of excretion from the body [3].At peripheral level, prolonged exposure to Cd will cause toxic effect due to its accumulation over time in a variety of tissues, including kidneys, liver, central nervous system (CNS), and peripheral neuronal systems [4]. At central level, the transport of Cd through the blood-brain barrier (BBB) is the first step in regulating the entries of the metal into the CNS. Also, Cd can be taken from the nasal mucosa or olfactory pathways into the CNS [5]. It is well known in the CNS that the heavy metals, including Cd, act as catalysts for biochemical reactions, regulators of gene expression, second messengers in signaling pathways and cofactors for many vital enzymes, such pathways implicated in regulating physiological, pathological and behavioral functions. Chronical exposure to Cd affects many nervous syste...

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“…Previous studies reported that daizepam and amnesia or cognitive impairment and antianxiety effect in rodents. [ 14 15 ]…”

Section: Discussionmentioning

confidence: 99%

Investigation of the Asyogh's rectangular device for learning and memory testing in Wistar rats

Yadav

2023

Indian J Pharmacol

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This study aimed to design Asyogh’s rectangular device that is used for memory testing in rodents. It was found that scopolamine (3 mg/kg i.p.) and diazepam (1 mg/kg i.p.) caused significant memory deficits in rats, as evidenced by increased transfer latency times. However, these memory deficits were significantly reversed when the rats were pretreated with Donepezil. It further demonstrates that pretreated donepezil is able to effectively restore the memory deficits induced by scopolamine and diazepam, as indicated by the significant recovery in TLT. The present study showed that the device used to measure transfer latency time that was a valuable tool for assessing memory and cognitive function in rodents.

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Melatonin and Diazepam Affect Anxiety-Like and Depression-Like Behavior in Wistar Rats: Possible Interaction with Central GABA Neurotransmission

Cited by 8 publications

References 50 publications

Neuroprotective effect of melatonin on nickel-induced affective and cognitive disorders and oxidative damage in rats

Neuroprotective effect of melatonin on nickel-induced affective and cognitive disorders and oxidative damage in rats

Effect of Chronic Administration of Cadmium on Anxiety-Like, Depression-Like and Memory Deficits in Male and Female Rats: Possible Involvement of Oxidative Stress Mechanism

Investigation of the Asyogh's rectangular device for learning and memory testing in Wistar rats

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