Melatonin and cortisol profiles in patients with pituitary tumors

Zielonka, Daniel; Sowiński, Jerzy; Nowak, S.; Ciesielska, Anna; Moskal, Jakub; Marcinkowski, Jerzy T.

doi:10.1016/j.pjnns.2014.12.004

Cited by 5 publications

(5 citation statements)

References 20 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Decreased levels of melatonin, resulting in disturbed circadian rhythm, may also be caused by optic chiasm exertion. It may occur in pituitary macroadenoma -in a reported case series one of four patients with macroadenoma pressing the optic chiasm, and one patient with macroadenoma but without pressure had a flattened rhythm of melatonin secretion [20] . In another observational study, abnormalities in melatonin secretion were reported in 70,59% of patients with non-functioning pituitary macroadenomas [21] .…”

Section: Discussionmentioning

confidence: 96%

Pineal cyst-related sleep disorders – a narrative review

Gałązka,

Domagalski,

Hoffman

et al. 2023

J Educ Health Sport

View full text Add to dashboard Cite

The pineal gland is an endocrine gland, which is responsible for the human circadian rhythm, through the regulation of its hormone – melatonin. The most common pathology of a pineal gland is pineal cyst – its population incidence is estimated as 1-23%, depending on the publication. The most common symptoms of a pineal cyst include headache (87%), visual field defects (54%), nausea/vomiting (34%), and dizziness/vertigo (31%). Among the majority of patients with the asymptomatic pineal cyst, the wait-and-see strategy is proper. According to the newest meta-analyze, the prevalence of sleep disturbances among patients with pineal cyst estimates to be 17%. The results of direct melatonin level measurements in pineal cysts remain unclear. The study focused on sleep disturbances in pediatric patients with pineal cysts and showed a significantly higher score on Sleep Disturbance Scale for Children (SDSC) in the domains of disorders of excessive sleepiness and disorders of initiating and maintaining sleep than the control groups. The impact of lesion on sleep quality correlated with its size. The pineal cyst may be considered a rare, and potentially reversible, cause of sleep disorders. Nevertheless, according to the present reports (often opposite to each other), this thesis and the mechanism of its occurrence need to be further researched.

show abstract

Section: Discussionmentioning

confidence: 96%

Pineal cyst-related sleep disorders – a narrative review

Gałązka,

Domagalski,

Hoffman

et al. 2023

J Educ Health Sport

View full text Add to dashboard Cite

show abstract

“…These findings suggested involvement of circadian clock in pituitary tumorigenesis. In support of this, patients with pituitary adenomas are associated with severe disturbances in circadian rhythms, as exemplified by disrupted sleep-wake cycle, altered diurnal patterns of melatonin and cortisol, and disturbed movement rhythm [22,[24][25][26].…”

Section: Disruption Of Pituitary Clock Genes In Patients With Pituita...mentioning

confidence: 99%

PER2 integrates circadian disruption and pituitary tumorigenesis

Guo¹,

Cen²,

Weng³

et al. 2023

Theranostics

View full text Add to dashboard Cite

Rationale:The role of circadian clock in pituitary tumorigenesis remains elusive. Here we investigate whether and how circadian clock modulates the development of pituitary adenomas. Methods and Results: We found altered expression of pituitary clock genes in patients with pituitary adenomas. In particular, PER2 is prominently upregulated. Further, jetlagged mice with PER2 upregulation have accelerated growth of GH3 xenograft tumor. Conversely, loss of Per2 protects mice against developing estrogen-induced pituitary adenoma. Similar antitumor effect is observed for SR8278, a chemical that can decrease pituitary PER2 expression. RNA-seq analysis suggests involvement of cell cycle disturbance in PER2 regulation of pituitary adenoma. Subsequent in vivo and cell-based experiments validate that PER2 induces pituitary expression of Ccnb2, Cdc20 and Espl1 (three cell cycle genes) to facilitate cell cycle progression and inhibit apoptosis, thereby promoting pituitary tumorigenesis. Mechanistically, PER2 regulates the transcription of Ccnb2, Cdc20 and Espl1 through enhancing the transcriptional activity of HIF-1α. HIF-1α trans-activates Ccnb2, Cdc20 and Espl1 via direct binding to its specific response element in the gene promoters. Conclusion: PER2 integrates circadian disruption and pituitary tumorigenesis. These findings advance our understanding of crosstalk between circadian clock and pituitary adenomas and highlight the relevance of clock-based approaches in disease management.

show abstract

“…These irregular sleep-wake patterns may be attributable to disruption in normal diurnal melatonin secretion. Altered patterns of melatonin secretion with shifted or absent nocturnal peak and/or inadequate daytime suppression have been demonstrated in some patients with tumors of the sellar/parasellar, suprasellar/hypothalamic, and pineal regions [46][47][48][49][50][51][52]. The specific melatoninregulating circadian pathway affected varies with tumor location.…”

Section: Circadian Rhythm Sleep Disordersmentioning

confidence: 99%

“…The specific melatoninregulating circadian pathway affected varies with tumor location. Tumors affecting the optic chiasm may interrupt photoneural input to the SCN travelling via the retinohypothalamic tract [51]. Sellar and suprasellar tumors may directly damage the SCN or its melatonin-regulating afferents [47,50].…”

Section: Circadian Rhythm Sleep Disordersmentioning

confidence: 99%

Sleep Disorders in Children with Central Nervous System Tumors

Maloney¹,

Lewinter²,

Ward³

et al. 2018

obm neurobiol

View full text Add to dashboard Cite

Sleep complaints are common in pediatric patients with central nervous system (CNS) tumors. These problems may result from disruption of normal homeostatic, circadian, neuroendocrine, and cardiorespiratory pathways and vary by tumor location and treatment received. Children with tumors within the hypothalamus and surrounding regions are prone to excessive daytime sleepiness. Sleep-related breathing disorders, especially those involving abnormal control of breathing, may occur in patients with tumors of the brainstem and posterior fossa. Maintaining a high index of suspicion for sleep disorders in children with CNS tumors is essential for early recognition and treatment. In this article, we will review the various sleep problems reported in pediatric brain tumor survivors, explore underlying neurobiological mechanisms, and discuss approaches to screening and diagnosis.Sleep is an essential physiologic function for growth, cognition, and physical and emotional well-being. It is particularly important in childhood, when the brain and body are undergoing rapid development. Normal sleep occurs through a complex interplay between homeostatic, circadian, neuroendocrine, and cardiorespiratory pathways. Cancer and cancer treatment may cause disruptions and imbalances in these pathways, resulting in abnormal sleep. Compared to the general population, pediatric cancer survivors are more likely to experience sleep problems. Patients with a history of brain tumors are particularly prone to sleep issues. In this article, we will review the physiology of normal sleep, describe the sleep problems and pathophysiologic mechanisms behind disrupted sleep in children with central nervous system (CNS) tumors, and discuss strategies for screening, diagnosis, and management. Sleep Mechanisms and PhysiologySleep and wakefulness. Sleep is fundamentally important in promoting growth, repair, and neurocognitive functioning. The timing, duration, and quality of sleep depend on complex, balanced interactions between sleep-promoting and wake-promoting pathways. The majority of these pathways are housed in the basal forebrain, diencephalon, and brainstem. The balance between sleep and wakefulness is governed by two distinct biologic processes: sleep-wake homeostasis (Process S) and circadian rhythm (Process C) [1]. Homeostatic drive to sleep intensifies with continued wakefulness over time and subsides as an individual sleeps. During the day, the sleep-dependent homeostatic drive is counteracted by sleep-independent circadian arousal mechanisms. Circadian rhythms are coordinated by an internal pacemaker housed in the bilateral suprachiasmatic nuclei (SCN) of the anterior hypothalamus [1]. The near-24 hour circadian rhythm is externally entrained by the light-dark cycle on Earth through direct input received by the SCN from retinal ganglion cells via the retinohypothalamic tract, which runs through the optic chiasm [2,3]. Additional input from the intergeniculate leaflet and median raphe nucleus modulate circadian phase shifts [3]. The SCN sends...

show abstract

Melatonin and cortisol profiles in patients with pituitary tumors

Cited by 5 publications

References 20 publications

Pineal cyst-related sleep disorders – a narrative review

Pineal cyst-related sleep disorders – a narrative review

PER2 integrates circadian disruption and pituitary tumorigenesis

Sleep Disorders in Children with Central Nervous System Tumors

Contact Info

Product

Resources

About