Melatonin and chlorpromazine: Thermal selection in the mudpuppy,

Hutchison, Victor H.; Black, Jerry J.; Erskine, Dale J.

doi:10.1016/0024-3205(79)90565-4

Cited by 20 publications

(5 citation statements)

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“…cells by the gland and thereby allow it to exert influences on various neurotransmitter systems and homeostatic functions including, among others, regulation of brain monoamines (Aldegunde et al, 1985;Anton-Tay et al, 1971;Bradbury et al, 1985;Sugden & Morris, 1979;Wendel et al, 1974;Nair et al, 1986), opioid peptide (Kumar et al, 1984;Lissoni et al, 1986). Melanocyte-stimulating hormone (MSH) release (Kastin et al, 1967;Kastin et al, 1972), endocrine regulation (Datta & King, 1978;Erlich & Apuzzo, 1985), thermoregulation (Kavaliers, 1982;Hutchison et al, 1979), and regulation of pain mechanisms (Kavaliers et al, 1983;Lakin et al, 1981). In addition, it has been suggested that the pineal gland acts as a "biological clock," as a neuroendocrine transducer" and as a "central inhibitory modulator" and its functions have been thought to exert long lasting effects on the CNS (Datta & King, 1978).…”

Section: Tablementioning

confidence: 97%

“…Malignant hyperthermia has been reported in association with levodopa therapy or withdrawal of levodopa (Szabadi, 1984;Henderson & Wooten, 198 l), suggesting that the hypothalamic thermoregulatory systems are prone to deregulation in levodopa-treated patients. Since L-dopa has been reported to stimulate the release of melatonin in rats (Lynch et al, 1973), and melatonin influences the hypothalamic thermoregulatory mechanisms (Kavaliers, 1982;Hutchison et al, 1979), it is possible that deregulation of melatonin functions may in part be associated with the chain of hypothalamic events leading to the development of malignant hyperthermia in susceptible Parkinsonian patients. Alternatively, deregulation of hypothalamic opioid peptide functions has been implicated in the pathogenesis of the neuroleptic malignant syndrome (Sandyk & Iacono, 1986).…”

Section: R Sandykmentioning

confidence: 99%

“…Recent animal studies have suggested that pineal melatonin is involved in central thermoregdation (Kavaliers, 1982;Hutchison et al, 1979). Pineal melatonin has been suggested to be part of a "circadian clock" governing various physiological activities including CI rcadian thermoregulation (Hutchison et al, 1979).…”

Section: R Sandykmentioning

confidence: 99%

“…Pineal melatonin has been suggested to be part of a "circadian clock" governing various physiological activities including CI rcadian thermoregulation (Hutchison et al, 1979). Disturbances in thermoregulatary mechanisms as part of a complex autonomic dysregulation are common in PD patients.…”

Section: R Sandykmentioning

confidence: 99%

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Pineal Melatonin Functions: Possible Relevance to Parkinson's Disease

Sandyk

1990

International Journal of Neuroscience

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Barbeau hypothesized that Parkinson's disease is associated with hypothalamic deficiency of the specialized neuroendocrine cell system (A.P.U.D.) and that the degeneration of brainstem monoaminergic neurons is secondary to progressive functional loss of this cell system in the disease. The pineal gland meets criteria of the A.P.U.D. cell system and it is possible that dysfunction of the pineal gland may be associated with the pathophysiology and clinical manifestations of Parkinson's disease. Since the role of pineal melatonin in humans remains enigamatic, it is currently unclear which of the symptoms of Parkinson's disease may be associated with deregulation of the secretory activity of pineal melatonin. This review summarizes evidence linking possible alterations of pineal melatonin functions with the clinical manifestations of Parkinson's disease.

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Section: Tablementioning

confidence: 97%

Section: R Sandykmentioning

confidence: 99%

Section: R Sandykmentioning

confidence: 99%

Section: R Sandykmentioning

confidence: 99%

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Pineal Melatonin Functions: Possible Relevance to Parkinson's Disease

Sandyk

1990

International Journal of Neuroscience

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“…The light/dark cycle is a major environmental factor that influences the physiology and the behavior of most organisms (Albrecht and Oster 2001). This rhythm is known to have important effects on animal body temperature (Erskine and Hutchison 1982), physiological performance (e.g., tolerance to higher temperatures) (Hutchison et al 1979), food intake (Zhou et al 1998), activity patterns (e.g. vertical migration exhibited by salamanders; Anderson and Graham 1967) and a variety of other behaviors (e.g., reproductive, antagonistic and antipredator behavior) (Rand et al 1997;Wise and Jaeger 1998;da Silva Nunes 1988).…”

Section: Introductionmentioning

confidence: 99%

Food level and light conditions affect the antipredator behavior in larvae of a stream-breeding amphibian

Băncilă

Plăiaşu

Stănescu

et al. 2021

Behav Ecol Sociobiol

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Understanding how long-term changes in environmental conditions influence the way that individuals cope with threats is essential in the context of behavioral adaptation to a rapidly changing world. However, little is known about the behavioral responses to predation risk for individuals that experienced different environmental conditions for extended periods of time, such as food levels and light conditions. In this experimental study, we tested whether previous long-term exposure to different food levels (low versus high) and light conditions (0-hour light versus 8-hour light) play a significant role in shaping the antipredator response (i.e., the probability of emerging from the refuge and the distance moved) to stimuli from caged larval dragonflies, in larvae of the fire salamander (Salamandra salamandra). Specifically, we quantified behavioral differences in the response to predation risk in larval salamanders that were reared in the laboratory for two months under controlled food and light conditions. The results of this study showed that the interaction between food level and light conditions affected the antipredator behavior of the larvae. Fire salamander larvae maintained at low food levels and in 8-hour light conditions emerged from the refuge with a higher probability (i.e., took more risk) than larvae maintained at high food levels and all other combinations of light conditions. Thus, our results highlight the complexity of antipredator responses, pointing attention to the fact that interactions among environmental factors are likely to determine the magnitude of antipredator response. Significance StatementFew studies have investigated the role of multiple environmental factors on the expression of predator-induced behavioral responses. Specifically, because no study has so far investigated the risk-taking behavior in individuals exposed to long-term, contrasting food levels and light conditions, we investigated this in amphibian larvae. We showed that environmental conditions interactively determined antipredator behavior. This highlights the importance of considering long-term environmental conditions experienced by an organism and their interactions when experimentally studying behavioral variation to adequately understand its expression in natural conditions.

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Behavioral Thermoregulation and the Role of Melatonin in a Nocturnal Snake

Lutterschmidt

Ford

et al. 2002

Hormones and Behavior

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Melatonin and chlorpromazine: Thermal selection in the mudpuppy,

Cited by 20 publications

References 17 publications

Pineal Melatonin Functions: Possible Relevance to Parkinson's Disease

Pineal Melatonin Functions: Possible Relevance to Parkinson's Disease

Food level and light conditions affect the antipredator behavior in larvae of a stream-breeding amphibian

Behavioral Thermoregulation and the Role of Melatonin in a Nocturnal Snake

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