Melatonin and childhood refractory epilepsy

Paprocka, Justyna; Dec, Renata; Jamroz, Ewa; Marszał, Elżbieta

doi:10.1016/s1090-3798(08)70138-7

Cited by 14 publications

(16 citation statements)

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“…83 Paprocka et al assessed diurnal melatonin secretion in children with refractory epilepsy as compared to children without epileptic seizures. 84 Analysis of diurnal melatonin secretion indicated a lower level of the hormone in patients with refractory epilepsy. They concluded that a lowered level of melatonin in children with refractory epilepsy in relation to the control group is the consequence of the intractable epilepsy or is influenced by antiepileptic drugs.…”

Section: Childhood Seizure Disordersmentioning

confidence: 99%

Melatonin utility in neonates and children

Chen

Tain

Sheen

et al. 2012

Journal of the Formosan Medical Association

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Melatonin (N-acetyl-5-methoxytryptamine) is an endogenously produced indoleamine secreted by the pineal gland and the secretion is suppressed by light. Melatonin is a highly effective antioxidant, free radical scavenger, and has anti-inflammatory effect. Plenty of evidence supports the utility of melatonin in adults for cancer, neurodegenerative disorders, and aging. In children and neonates, melatonin has been used widely, including for respiratory distress syndrome, bronchopulmonary dysplasia, periventricular leukomalacia (PVL), hypoxia-ischemia encephalopathy and sepsis. In addition, melatonin can be used in childhood sleep and seizure disorders, and in neonates and children receiving surgery. This review article discusses the utility of melatonin in neonates and children.

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Section: Childhood Seizure Disordersmentioning

confidence: 99%

Melatonin utility in neonates and children

Chen

Tain

Sheen

et al. 2012

Journal of the Formosan Medical Association

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“…Moreover, the time since last seizure has a significant effect on the secretion of melatonin. It should be noted that antiepileptic treatment itself may affect melatonin secretion, which, in fact, was seen in our studies [35,42]. On the contrary, Dabak et al showed lower post-seizure melatonin levels in the patients with febrile and afebrile seizures [43].…”

Section: Melatonin -Molecular Biology Clinical and Pharmaceutical Apmentioning

confidence: 39%

“…In epilepsy, melatonin secretion may be disturbed: higher nocturnal melatonin concentrations, a higher melatonin concentration after seizures, or loss/shift of the characteristic diurnal rhythm of secretion are reported by some authors [35][36][37][38][39][40], while other authors found low baseline levels [41,42]. Melatonin concentration in patients with epilepsy is sometimes claimed to be slightly increased or unchanged as compared to normal values [38,43].…”

Section: Melatonin -Molecular Biology Clinical and Pharmaceutical Apmentioning

confidence: 99%

Melatonin in Childhood Epilepsy and in Child Neurology

Paprocka¹,

Kijonka²,

Sokół³

2018

Melatonin - Molecular Biology, Clinical and Pharmaceutical Approaches

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Melatonin (MLT) was isolated as a hormone by Lerner in 1958, and since then, intense studies have been under way with respect to its action and possibilities of application in various fields of medicine. Despite the existence of multiple antiepileptic medications and progress that has taken place in neurosurgical treatment of epilepsy, drug-resistant epilepsy continues to be a phenomenon that occurs in 30-35% children treated for epileptic seizures. Reports presented in the study have shown that children with epilepsy suffer from sleep disorders. Sleep deprivation may cause seizures, and on the other hand, an increased frequency of seizures may lead to sleep disturbances.

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“…Our data suggest that not only disordered sleep but also the shift of melatonin secretion may be expected in TSC children with frequent seizures; unfortunately, this supposition is based on the results gathered from a small TSC group, too. However, our previous studies performed on the large epileptic group strongly confirm it [7, 26]. Examination of melatonin secretion in patients with epilepsy has shown higher nocturnal MLT concentration, increase of MLT concentration during or after seizure, shift or loss of MLT circadian rhythm, or comparable to controls [7, 26].…”

Section: Discussionmentioning

confidence: 64%

Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods

Paprocka

Kijonka

Boguszewicz

et al. 2017

International Journal of Endocrinology

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Purpose. The aim of the study was to assess melatonin secretion pattern in children with TSC and to compare it with the secretion patterns in children with and without epilepsy. Material and Methods. Melatonin secretion was measured every three hours using the RIA method in four children with recognized TSC. The parameters of the melatonin secretion models were interpreted and compared with those obtained for the patients with epilepsy (n = 76) and the children from the control, nonepileptic group (n = 36). To describe the diurnal melatonin secretion, mathematical model was constructed and nonlinear least squares method with the Levenberg-Marquardt optimization algorithm was applied to approximate its parameters. The dim light melatonin onset (DLMO) parameters were also estimated from the model. Results and Conclusions. Statistically significant differences were found between the TSC melatonin secretion profiles and the nonepileptic control group. The profiles for the epileptic and TSC groups were found to be similar. For the TSC group, though a small one, the variations in the MLT release amplitudes seem to be independent of the total number of seizures; however, the MLT release shift appears to depend on the number of seizures.

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Melatonin and childhood refractory epilepsy

Cited by 14 publications

References 0 publications

Melatonin utility in neonates and children

Melatonin utility in neonates and children

Melatonin in Childhood Epilepsy and in Child Neurology

Melatonin in Tuberous Sclerosis Complex Analysis Using Modern Mathematical Modeling Methods

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