Melatonin ameliorates sodium valproate-induced hepatotoxicity in rats

Öztopuz, Özlem; Türkön, Hakan; Bűyűk, Başak; Coşkun, Özlem; Şehitoğlu, Müşerref Hilal; Ovalı, Mehmet Akif; Uzun, Metehan

doi:10.1007/s11033-019-05134-6

Cited by 37 publications

(21 citation statements)

References 31 publications

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“…They observed that higher activities of these enzymes leading to more liver damage. Enzymes like ALT, AST, and ALP are the most frequently used serum markers to elucidate injury in liver hence they are called serum aminotransferases 22 . Few researchers reported elevated levels of serum AST, ALT, and ALP in Cyprinus carpio and Channa punctatus in response to heavy metals exposure 23,24 .…”

Section: Resultsmentioning

confidence: 99%

Heavy metal pollution and risk assessment by the battery of toxicity tests

Khan

Javed

Rehman

et al. 2020

Sci Rep

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The current study was carried out on dominant fish Oreochromis niloticus and water collected from the polluted Yamuna River, Agra, India. The heavy metals in water, recorded as follows: Fe > Mn > Zn > Cu > Ni > Cr > Cd and all were found to be above the prescribed limits. According to metal pollution index, exposed muscle (49.86), kidney (47.68) and liver (45.26) have been recorded to have higher bioaccumulation. The blood biochemical analysis of exposed O. niloticus indicated significant increase in activities of aspartate aminotransferase (+ 343.5%), alkaline phosphatase (+ 673.6%), alanine aminotransferase (+ 309.1%), and creatinine (+ 494.3%) over the reference. However, a significant decrease in albumin (A): globulins (G) ratio (− 87.86%) was observed. Similarly, the exposed fish also showed significant increase in total leucocyte count (+ 121%), differential leucocyte count, respiratory burst (+ 1175%), and nitric oxide synthase (+ 420%). The histological examination of liver and kidney showed tissue injury. Moreover, micronuclei (0.95%), kidney shaped nuclei (1.2%), and lobed nuclei (0.6%) along with DNA damage in the form of mean tail length in the liver (20.7 µm) and kidney (16.5 µm) was observed in the exposed O. niloticus. Potential health risk assessments based on estimated daily intake, target hazard quotient, hazard index, and target cancer risk indicated health risks associated with the consumption of these contaminated fishes. In conclusion, the present study showed that exposure to heavy metals contaminated water can alter immunological response; induce histopathological alterations and DNA damage in the studied fish. The consumption of this contaminated water or fish could have serious impact on human health.

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Section: Resultsmentioning

confidence: 99%

Heavy metal pollution and risk assessment by the battery of toxicity tests

Khan

Javed

Rehman

et al. 2020

Sci Rep

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“…Recently, Barisic et al 32 noticed an exposure-duration-related alteration in serum ALT, ALP, and AST of salmon fish as the higher the activity the more was liver damage. ALT, ALP, and AST are serum markers, mainly used to interpret damage in the liver and thus, they are known as serum aminotransferases 33,34 . Many investigators revealed an increased measure of serum ALT, ALP, and AST in Tilapia zillii, Mugil cephalus, Oncorhynchus mykiss, and Barbus luteus due to heavy metals exposure 18,35,36 .…”

Section: Effect Of Heavy Metals On Enzyme Activitiesmentioning

confidence: 99%

Labeo rohita, a bioindicator for water quality and associated biomarkers of heavy metal toxicity

et al. 2021

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This study investigated the effect of heavy metals on Labeo rohita inhabiting the Yamuna River, India. Levels of heavy metals measured in the water were as follows: Fe>Mn>Zn>Cu>Ni>Cr>Cd. Gill and liver tissue of exposed L. rohita showed a high metal pollution index, compared to reference fish collected from the Agra Canal. In the exposed fish, higher levels of creatinine and enzyme activity (alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase) were observed, while the A:G index declined. Additionally, higher TLC, lymphocytes, respiratory burst, and nitric oxide synthase activity indicated a heightened immune response. Levels of superoxide dismutase and lipid peroxidation were elevated, while catalase, glutathione S transferase, and glutathione was reduced. DNA of the exposed fish appeared deteriorated, with a greater mean tail length in comparison to the reference. Our results imply that Yamuna River water generates oxidative stress and DNA damage in L. rohita. As this river is a critical source of water and food to the native community, this could pose a threat to public health similar to that in the indicator organism.

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“…VPA elevated expression of proinflammatory cytokines including IL-1β and TNFα as well as hepatocyte apoptosis and melatonin administration (10 mg/kg via gavage, 1 hours prior to VPA treatment for 14 days) inhibited those effects. 75 Dexamethasone (DEX) is a type of corticosteroids used to decrease inflammatory responses, but it can cause liver steatosis. A previous study administered DEX to pregnant rats at gestational day 14-21, and rats were sacrificed at postnatal day 120.…”

Section: Toxin-induced Liver Injurymentioning

confidence: 99%

“…Valproic acid (VPA) is a mood‐stabilizing agent used for psychiatric disorders, but also causes liver damage. VPA elevated expression of proinflammatory cytokines including IL‐1β and TNFα as well as hepatocyte apoptosis and melatonin administration (10 mg/kg via gavage, 1 hours prior to VPA treatment for 14 days) inhibited those effects . Dexamethasone (DEX) is a type of corticosteroids used to decrease inflammatory responses, but it can cause liver steatosis.…”

Section: Functional Roles and Therapeutic Potentials Of Melatonin Andmentioning

confidence: 99%

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

Sato

Meng

Francis

et al. 2020

Journal of Pineal Research

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Circadian rhythms and clock gene expressions are regulated by the suprachiasmatic nucleus in the hypothalamus, and melatonin is produced in the pineal gland. Although the brain detects the light through retinas and regulates rhythms and melatonin secretion throughout the body, the liver has independent circadian rhythms and expressions as well as melatonin production. Previous studies indicate the association between circadian rhythms with various liver diseases, and disruption of rhythms or clock gene expression may promote liver steatosis, inflammation, or cancer development. It is well known that melatonin has strong antioxidant effects. Alcohol drinking or excess fatty acid accumulation produces reactive oxygen species and oxidative stress in the liver leading to liver injuries. Melatonin administration protects these oxidative stress‐induced liver damage and improves liver conditions. Recent studies have demonstrated that melatonin administration is not limited to antioxidant effects and it has various other effects contributing to the management of liver conditions. Accumulating evidence suggests that restoring circadian rhythms or expressions as well as melatonin supplementation may be promising therapeutic strategies for liver diseases. This review summarizes recent findings for the functional roles and therapeutic potentials of circadian rhythms and melatonin in liver diseases.

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Melatonin ameliorates sodium valproate-induced hepatotoxicity in rats

Cited by 37 publications

References 31 publications

Heavy metal pollution and risk assessment by the battery of toxicity tests

Heavy metal pollution and risk assessment by the battery of toxicity tests

Labeo rohita, a bioindicator for water quality and associated biomarkers of heavy metal toxicity

Melatonin and circadian rhythms in liver diseases: Functional roles and potential therapies

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