Melatonin ameliorates renal ischemia/reperfusion injury

Rodrı́guez-Reynoso, Sergio; Leal, Caridad; Buen, Eliseo Portilla-de; Castillo, Juan Carlos; Ramos-Solano, Francisco

doi:10.1016/j.jss.2003.10.002

Cited by 60 publications

(58 citation statements)

References 34 publications

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“…The protective effects of melatonin against 2,4-D were described by Bongiovanni et al [16] in which they showed an amelioration by melatonin against oxidative stress produced by 2,4-D in rat cerebellar granular cells. Melatonin was shown as beneficial in preserving the renal function of rats against iron overload-induced toxicity and in renal ischemia-reperfusion injury by reducing lipid peroxidation, increasing glutathione levels, and preventing the increase in nitrite levels [36,37]. In this study also, administration of melatonin at a dose of 10 mg/kg body weight to 2,4-D-administered mice revealed ameliorative histological effects in the kidney.…”

Section: Discussionsupporting

confidence: 52%

Ameliorative Effects of Melatonin Against 2,4-Dichlorophenoxyacetic Acid Toxicity in Kidney of Mice – A Histological Study.

Upadhyaya

Rao

Jhala

2018

Asian J Pharm Clin Res

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Objective: The compound, 2,4-dichlorophenoxyacetic acid (2,4-D), is a systemic phenoxy herbicide and a plant growth regulator. Histopathological effects of 2,4-D alone and in combination with melatonin on the kidney in adult albino male mice of the Swiss strain were evaluated in the present study.Methods: Twenty adult male albino mice weighing between 30 and 40 g were assigned into four groups with five mice in each group. Group I served as control; Group II -melatonin alone (10 mg/kg body weight); Group III -2,4-D alone (50 mg/kg body weight); and Group IV -2,4-D + melatonin was given orally for 45 days.Results: It revealed a significant reduction in the body and kidney weights (p<0.001 and p<0.01 respectively) of mice treated with 2,4-D, while the body and kidney weights after treatment of melatonin and 2,4-D + melatonin were comparable to control. Histological study revealed that 2,4-D induced nephrotoxicity evidenced by various histological changes including shrinkage of the glomerulus, tubular dilation, hypertrophy of tubular epithelium, and degeneration of renal tubules. Conclusion:Treating animals with the melatonin along with 2,4-D showed mitigative effects of melatonin and minimized the structural alteration in the kidney of mice appeared due to 2,4-D toxicity.

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Section: Discussionsupporting

confidence: 52%

Ameliorative Effects of Melatonin Against 2,4-Dichlorophenoxyacetic Acid Toxicity in Kidney of Mice – A Histological Study.

Upadhyaya

Rao

Jhala

2018

Asian J Pharm Clin Res

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“…Previous experiments show that various exogenous antioxidant agents such as allopurinol, melatonin, tocopherol, leflunomide, and some flavonoids have the potential to reduce I/R induced-renal injury and help the improvement of kidney function. [10,[13][14][15]26] In this study, we used AA as an exogenous antioxidant. AA is one of the water-soluble vitamins and is well known as a strong antioxidant agent.…”

Section: Discussionmentioning

confidence: 99%

“…[3,14] Additionally, N-acetylcysteine, α-tocopherol, and melatonin administered to rats following I/R decrease the ROS levels providing kidney damage protection. [2,3,[13][14][15] Several experimental studies suggest that antioxidant vitamins, including ascorbic acid (AA), produce cytoprotective effects due to reduction of ROS. [16] Thus, AA is a very powerful antioxidant agent.…”

Section: Introductionmentioning

confidence: 99%

The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

Korkmaz

Kolankaya

2009

Renal Failure

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“…2 Ischemia-reperfusion (I/R) injury is a complex phenomenon and it leads to structural and functional cell damage. 3 One of the most important factors in pathophysiology of renal IR injury is reactive oxygen species (ROS), which especially increases in the reperfusion phase. 2 The endogenous antioxidants which are responsible for defence against ROS during reperfusion have an important role in decreasing IR injury.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Melatonin and 1,25-Dihydroxyvitamin D3 on Renal Ischemia–Reperfusion Injury in Rats

et al. 2013

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Ischemia-reperfusion (I/R) injury induces the generation of reactive oxygen species (ROS) which affect many organs. This study was designed to investigate the roles of melatonin and 1,25-dihydroxyvitamin D 3 (VD3) on renal I/R injury. Thirty male Wistar albino rats were divided into five groups: group 1, control; group 2, right nephrectomy (RN) þ I/R in the contralateral kidney; group 3, melatonin þ RN þ I/R; group 4, VD 3 þ RN þ I/R; and group 5, melatonin þ VD 3 þ RN þ I/R. Melatonin (10 mg/kg), VD3 (0.5 μg/kg), and melatonin plus VD3 were injected intraperitoneally for 7 days before renal I/R. After 7 days, right nephrectomy was initially performed and left renal artery was clamped for 45 min. After 45-min reperfusion, the serum and kidney tissue samples were obtained for assays. Melatonin and VD3 had an ameliorative effect on biochemical parameters such as serum creatinine (SCr) and blood urea nitrogen (BUN). Renal tissue malondialdehyde (MDA), glutathione (GSH), nitric oxide (NO) levels, and superoxide dismutase (SOD) activity were determined. Renal I/R decreased the kidney tissue GSH levels and SOD activity and increased the NO levels as compared with control group. However, melatonin and VD3 and melatonin plus VD3 treatment significantly increased the tissue GSH levels and SOD activity and decreased the NO levels compared with those of I/R group. Meanwhile, MDA levels were not different between the control and I/R groups. But, MDA levels decreased in all treated groups compared to I/R and control groups. These data support that melatonin and VD3 have beneficial effects on renal injury.

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Melatonin ameliorates renal ischemia/reperfusion injury

Cited by 60 publications

References 34 publications

Ameliorative Effects of Melatonin Against 2,4-Dichlorophenoxyacetic Acid Toxicity in Kidney of Mice – A Histological Study.

Ameliorative Effects of Melatonin Against 2,4-Dichlorophenoxyacetic Acid Toxicity in Kidney of Mice – A Histological Study.

The Protective Effects of Ascorbic Acid against Renal Ischemia-Reperfusion Injury in Male Rats

Protective Effect of Melatonin and 1,25-Dihydroxyvitamin D3 on Renal Ischemia–Reperfusion Injury in Rats

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