Melatonin ameliorates bisphenol A-induced perturbations of the prostate gland of adult Wistar rats

Olukole, Samuel Gbadebo; Ajani, Samuel; Ola-Davies, Eunice Olufunke; Lanipekun, Damilare Olaniyi; Aina, Oluwasanmi Olayinka; Oyeyemi, M. O.; Oke, B. O.

doi:10.1016/j.biopha.2018.05.125

Cited by 28 publications

(34 citation statements)

References 58 publications

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“…Furthermore, histopathological alterations of the prostate were similar to those found when in-utero exposure took place (108). Notably, melatonin decreased lesions in the epithelium compartments, tubular atrophy and vascular congestion (110), suggesting a protective function.…”

Section: Exposure During Prenatal and Postnatal Lifesupporting

confidence: 62%

“…It has been demonstrated that melatonin protected from cellular damage caused by reactive oxygen species (109). Thus, Olukole et al (110) studied the effects of melatonin against the toxicity caused by BPA in adult rodents using prostate-specific antigen (PSA) measurement, revealing that the probability of developing PCa increased after 14 days of low-dose exposure. Furthermore, histopathological alterations of the prostate were similar to those found when in-utero exposure took place (108).…”

Section: Exposure During Prenatal and Postnatal Lifementioning

confidence: 99%

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Breast and prostate glands affected by environmental substances (Review)

Bleak

Calaf

2021

Oncol Rep

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Environmental endocrine disruptor chemicals are substances that can alter the homeostasis of the endocrine system in living organisms. They can be released from several products used in daily activities. Once in the organism, they can disrupt the endocrine function by mimicking or blocking naturally occurring hormones due to their similar chemical structure. This endocrine disruption is the most important cause of the well-known hormone-associate types of cancer. Additionally, it is decisive to determine the susceptibility of each organ to these compounds. Therefore, the present review aimed to summarize the effect of different environmental substances such as bisphenol A, dichlorodiphenyltrichloroethane and polychlorinated biphenyls in both the mammary and the prostate tissues. These organs were chosen due to their association with the hormonal system and their common features in carcinogenic mechanisms. Outcomes derived from the present review may provide evidence that should be considered in future debates regarding the effects of endocrine disruptors on carcinogenesis.

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Section: Exposure During Prenatal and Postnatal Lifesupporting

confidence: 62%

Section: Exposure During Prenatal and Postnatal Lifementioning

confidence: 99%

Breast and prostate glands affected by environmental substances (Review)

Bleak

Calaf

2021

Oncol Rep

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“…Akarca-Dizakar et al [ 130 ] showed that melatonin treatment improves sperm motility and quality in BPA-exposed rats. They also showed a positive effect of melatonin on the adrenal and prostate function in male rats administered BPA for 2 weeks [ 131 ]. Oral administration of melatonin increased the in vitro fertilization rate, alleviating the alterations in fertility related proteins, reducing ROS levels, and preventing oocyte apoptosis induced by BPA.…”

Section: Role Of Antioxidants In Overcoming Bpa Toxicitymentioning

confidence: 99%

Role of Antioxidants in Alleviating Bisphenol A Toxicity

2020

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Bisphenol A (BPA) is an oestrogenic endocrine disruptor widely used in the production of certain plastics, e.g., polycarbonate, hard and clear plastics, and epoxy resins that act as protective coating for food and beverage cans. Human exposure to this chemical is thought to be ubiquitous. BPA alters endocrine function, thereby causing many diseases in human and animals. In the last few decades, studies exploring the mechanism of BPA activity revealed a direct link between BPA-induced oxidative stress and disease pathogenesis. Antioxidants, reducing agents that prevent cellular oxidation reactions, can protect BPA toxicity. Although the important role of antioxidants in minimizing BPA stress has been demonstrated in many studies, a clear consensus on the associated mechanisms is needed, as well as the directives on their efficacy and safety. Herein, considering the distinct biochemical properties of BPA and antioxidants, we provide a framework for understanding how antioxidants alleviate BPA-associated stress. We summarize the current knowledge on the biological function of enzymatic and non-enzymatic antioxidants, and discuss their practical potential as BPA-detoxifying agents.

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“…BPA exposure also decreases the estrogen and progesterone levels, and increases pro-inflammatory cytokine levels [63]. Sub-acute oral administration of BPA (10 mg/kg BW/day) in adult Wistar rats increases the serum estrogen level and prostate-specific antigen, causing vascular congestion and hyperplasia of the prostatic epithelium [64]. BPA at low doses decreases the synthesis of estradiol and inhibits the growth of antral follicles isolated from wild-type and Ahr knock-out mice, through partial involvement of the aryl hydrocarbon receptor pathway [32].…”

Section: Endocrine Disruption and Reproductive Abnormalitiesmentioning

confidence: 99%

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

Kim

Kumar

et al. 2019

IJERPH

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Bisphenols are widely used in the synthesis of polycarbonate plastics, epoxy resins, and thermal paper, which are used in manufacturing items of daily use. Packaged foods and drinks are the main sources of exposure to bisphenols. These chemicals affect humans and animals by disrupting the estrogen, androgen, progesterone, thyroid, and aryl hydrocarbon receptor functions. Bisphenols exert numerous harmful effects because of their interaction with receptors, reactive oxygen species (ROS) formation, lipid peroxidation, mitochondrial dysfunction, and cell signal alterations. Both cohort and case-control studies have determined an association between bisphenol exposure and increased risk of cardiovascular diseases, neurological disorders, reproductive abnormalities, obesity, and diabetes. Prenatal exposure to bisphenols results in developmental disorders in animals. These chemicals also affect the immune cells and play a significant role in initiating the inflammatory response. Exposure to bisphenols exhibit age, gender, and dose-dependent effects. Even at low concentrations, bisphenols exert toxicity, and hence deserve a critical assessment of their uses. Since bisphenols have a global influence on human health, the need to discover the underlying pathways involved in all disease conditions is essential. Furthermore, it is important to promote the use of alternatives for bisphenols, thereby restricting their uses.

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Melatonin ameliorates bisphenol A-induced perturbations of the prostate gland of adult Wistar rats

Cited by 28 publications

References 58 publications

Breast and prostate glands affected by environmental substances (Review)

Breast and prostate glands affected by environmental substances (Review)

Role of Antioxidants in Alleviating Bisphenol A Toxicity

Bisphenols as a Legacy Pollutant, and Their Effects on Organ Vulnerability

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