Melatonin along with eCG improves fresh semen quality and plasma concentrations of melatonin and testosterone during non-breeding season in Beetal bucks

Abbas, Mohamed S.; Khan, M. Islam; Hameed, Nasir; Rehman, Abdul; Mohsin, Imran; Bilal, Muhammad; Shahzad, Muhammad

doi:10.1016/j.smallrumres.2021.106569

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…Thirty studies were performed in 15 countries, primarily Spain (16.67%), Australia (13.33%), and the UK (10.00%) ( Table-1 ) [ 9 – 38 ]. The percentages of sheep and goats were 80% and 20%, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…These findings are similar to those reported by Abbas et al . [ 9 ], who reported that injection of melatonin increases the concentration, normal morphology, acrosome, and DNA integrity of sperm in rams. Moreover, motility, acrosome, and DNA integrity in the post-thawed semen of melatonin-treated small ruminants were also increased.…”

Section: Discussionmentioning

confidence: 99%

“…The included studies are presented in Table-1 [ 9 – 38 ] as follows: First author’s name, year, location, species, season, dose, and research duration. The graphical data were extracted using WebPlotDigitizer (Automeris LLC, CA, USA) [ 42 ].…”

Section: Methodsmentioning

confidence: 99%

“…Melatonin administration has been intensively investigated to modulate reproductive cycles in small male ruminants. Melatonin injection has beneficial effects on testosterone production, sperm, and quality of post-thawed semen in sheep and goats during both breeding and non-breeding seasons [ 9 – 30 ]. Melatonin administration also mitigates sperm abnormalities in heat-stressed rams [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

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Impact of melatonin administration on sperm quality, steroid hormone levels, and testicular blood flow parameters in small ruminants: A meta-analysis

Budiyanto,

Hartanto,

Widayanti

et al. 2024

Vet World

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Background and Aim: The impact of exogenous melatonin on the sperm quality of small ruminants is controversial. Therefore, this study aimed to synthesize previous findings on the influence of melatonin injection on sperm quality, steroid hormones, and testicular blood flow in small ruminants. Materials and Methods: Thirty studies were analyzed by computing the raw mean difference (RMD) as the effect size between the control and melatonin treatment groups, using the inverse of the variance for the random-effect model of the method of moments by DerSimonian and Laird. We assessed heterogeneity among studies using Q test. I2 statistic was used to classify the observed heterogeneity. We used Egger’s regression method to indicate publication bias. Results: Melatonin injection (p < 0.05) affected sperm concentration (RMD = 0.42 × 109/mL), morphology (RMD = 2.82%), viability (RMD = 2.83%), acrosome integrity (RMD = 4.26%), and DNA integrity (RMD = 1.09%). Total motility (RMD = 5.62%), progressive motility (RMD = 7.90%), acrosome integrity (RMD = 8.68%), and DNA integrity (RMD = 2.01%) of post-thawed semen in the melatonin-treated group were also increased (p < 0.05). Similarly, treatment with melatonin (p < 0.05) enhanced total motility (RMD = 5.78%), progressive motility (RMD = 5.28%), curvilinear velocity (RMD = 4.09 μm/s), straight-line velocity (RMD = 5.61 μm/s), and average path velocity (RMD = 4.94 μm/s). Testosterone (RMD = 1.02 ng/mL) and estradiol 17-ß levels (RMD = 0.84 pg/mL) were elevated (p < 0.05) in the melatonin-injected group. Melatonin implantation ameliorated testicular blood flow, as indicated by a significant reduction (p < 0.05) in the resistive index (RMD = 0.11) and pulsatility index (RMD = –0.15). Conclusion: Melatonin administration can increase the reproductive performance of small male ruminants. Keywords: goat, implantation, melatonin, meta-analysis, reproduction, sheep.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%