Melatonin alleviates lead-induced fatty liver in the common carps (Cyprinus carpio) via gut-liver axis

Miao, Zhiying; Miao, Zhiruo; Teng, Xiaohua; Xu, Shiwen

doi:10.1016/j.envpol.2022.120730

Cited by 38 publications

(9 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fatty liver disease has become a common issue in aquaculture [39][40][41][42]. Hepatic glycolipid metabolism plays a crucial role in maintaining the organism's metabolism balance [43,44].…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis reveals resveratrol promotes lipid synthesis and induces apoptosis in Siberian sturgeon

Yang,

Yan,

Pang

et al. 2024

Preprint

View full text Add to dashboard Cite

Resveratrol, known for its antioxidant properties and ability to regulate glycolipid metabolism, has been revealed its benefit effects on the liver health of sturgeon. However, further investigation is needed to understand the specific mechanism of resveratrol's impact. In this study, we explore how resveratrol affects the liver of Siberian sturgeon at a specific concentration. The results showed that resveratrol treatment led to a significant increase in apoptosis after hepatic lipid synthesis, but did not activate the antioxidant NRF2/KEAP1 pathway or enhance antioxidant enzyme activity. Transcriptomics analysis also revealed significant changes in regulatory pathways related to glycolysis, including the PPAR signaling pathway, Insulin signaling pathway, Fatty acid biosynthesis, and Glycolysis/Gluconeogenesis. These findings highlight the close relationship between resveratrol and glycolipid metabolism. Moreover, the study demonstrated that high concentrations of resveratrol can have physiological toxicity to the liver of Siberian sturgeon, providing valuable insights for future research on fish feed additives dosage.

show abstract

“…Fatty liver disease has become a common issue in aquaculture [39][40][41][42]. Hepatic glycolipid metabolism plays a crucial role in maintaining the organism's metabolism balance [43,44].…”

Section: Discussionmentioning

confidence: 99%

Transcriptome analysis reveals resveratrol promotes lipid synthesis and induces apoptosis in Siberian sturgeon

Yang,

Yan,

Pang

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…In a study on common carp, Pb exposure induced fatty liver formation and intestinal injury. 122 Hepatocyte ferroptosis was associated with Pbinduced fatty liver, accompanied by lysosomal dyshomeostasis and inhibition of AMPK phosphorylation, leading to lipid metabolic disorders. The study also demonstrated the protective effects of melatonin against Pb toxicity by attenuating hepatocyte ferroptosis.…”

Section: Airborne Particulate Matter (Pm)mentioning

confidence: 99%

“…In addition, Pb is a widespread aquatic environmental contaminant known to cause hepatic injury in many animals. In a study on common carp, Pb exposure induced fatty liver formation and intestinal injury . Hepatocyte ferroptosis was associated with Pb-induced fatty liver, accompanied by lysosomal dyshomeostasis and inhibition of AMPK phosphorylation, leading to lipid metabolic disorders.…”

Section: Ferroptosis Inducers In Environmental Pollutantsmentioning

confidence: 99%

Ferroptosis Induced by Pollutants: An Emerging Mechanism in Environmental Toxicology

Yang,

Cai,

2024

Environ. Sci. Technol.

View full text Add to dashboard Cite

Environmental pollutants have been recognized for their ability to induce various adverse outcomes in both the environment and human health, including inflammation, apoptosis, necrosis, pyroptosis, and autophagy. Understanding these biological mechanisms has played a crucial role in risk assessment and management efforts. However, the recent identification of ferroptosis as a form of programmed cell death has emerged as a critical mechanism underlying pollutant-induced toxicity. Numerous studies have demonstrated that fine particulates, heavy metals, and organic substances can trigger ferroptosis, which is closely intertwined with lipid, iron, and amino acid metabolism. Given the growing evidence linking ferroptosis to severe diseases such as heart failure, chronic obstructive pulmonary disease, liver injury, Parkinson's disease, Alzheimer's disease, and cancer, it is imperative to investigate the role of pollutant-induced ferroptosis. In this review, we comprehensively analyze various pollutant-induced ferroptosis pathways and intricate signaling molecules and elucidate their integration into the driving and braking axes. Furthermore, we discuss the potential hazards associated with pollutant-induced ferroptosis in various organs and four representative animal models. Finally, we provide an outlook on future research directions and strategies aimed at preventing pollutant-induced ferroptosis. By enhancing our understanding of this novel form of cell death and developing effective preventive measures, we can mitigate the adverse effects of environmental pollutants and safeguard human and environmental health.

show abstract

“…Exogenous toxins also increase the synthesis of LPS, intensifying hepatocyte ferroptosis and resulting in hepatic lipid metabolic disorders. However, melatonin can decrease microbiota-derived LPS and hepatocyte ferroptosis by modulating the gut microbiota [ 84 ]. The total flavonoids of Rhizoma Drynaria can prevent oxidative stress and hepatic lipid deposition, reverse hepatic ferroptosis by improving the host intestinal microenvironment, and play a protective role in aflatoxin B1-induced liver damage [ 85 ].…”

Section: Advanced Studies On the Correlation Between The Gut Microbio...mentioning

confidence: 99%

Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease

Mao,

Gao,

Pan

et al. 2024

Cell Death Discov.

View full text Add to dashboard Cite

Ferroptosis is a novel form of lipid peroxidation-driven, iron-dependent programmed cell death. Various metabolic pathways, including those involved in lipid and iron metabolism, contribute to ferroptosis regulation. The gut microbiota not only supplies nutrients and energy to the host, but also plays a crucial role in immune modulation and metabolic balance. In this review, we explore the metabolic pathways associated with ferroptosis and the impact of the gut microbiota on host metabolism. We subsequently summarize recent studies on the influence and regulation of ferroptosis by the gut microbiota and discuss potential mechanisms through which the gut microbiota affects ferroptosis. Additionally, we conduct a bibliometric analysis of the relationship between the gut microbiota and ferroptosis in the context of chronic kidney disease. This analysis can provide new insights into the current research status and future of ferroptosis and the gut microbiota.

show abstract

Melatonin alleviates lead-induced fatty liver in the common carps (Cyprinus carpio) via gut-liver axis

Cited by 38 publications

References 64 publications

Transcriptome analysis reveals resveratrol promotes lipid synthesis and induces apoptosis in Siberian sturgeon

Transcriptome analysis reveals resveratrol promotes lipid synthesis and induces apoptosis in Siberian sturgeon

Ferroptosis Induced by Pollutants: An Emerging Mechanism in Environmental Toxicology

Ferroptosis: a potential bridge linking gut microbiota and chronic kidney disease

Contact Info

Product

Resources

About