Melatonin alleviates defects induced by zearalenone during porcine embryo development

Yao, Xuerui; Jiang, Hao; Gao, Qingshan; Li, Yinghua; Xu, Yong; Kim, Nam‐Hyung

doi:10.1016/j.theriogenology.2020.04.005

Cited by 20 publications

(9 citation statements)

References 33 publications

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“…Previous toxicity studies have indicated that at concentrations of 2.5 and 40 µm, ZEA reduced the survival of jejunal epithelial cells in piglets [9]. Furthermore, a study found that ZEA had adverse effects on the development of early porcine blastocysts [10], which is consistent with the observations of Kouadio et al [11], who demonstrated that ZEA can cause lipid peroxidation and lead to cell death. Heat shock protein 70 (Hsp70) is a ubiquitous member of the heat shock protein family found in most types of animal cells, and has been found to play range of different physiological roles, such as enhancing immune function and as an antioxidant [12].…”

Section: Introductionsupporting

confidence: 80%

Effects of Dietary Zearalenone Exposure on the Growth Performance, Small Intestine Disaccharidase, and Antioxidant Activities of Weaned Gilts

Liu

Yang

et al. 2020

Animals

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Zearalenone (ZEA) is a secondary metabolite with estrogenic effects produced by Fusarium fungi and mainly occurs as a contaminant of grains such as corn and wheat. ZEA, to which weaned gilts are extremely sensitive, is the main Fusarium toxin detected in corn–soybean meal diets. Our aim was to examine the effects of ZEA on the growth performance, intestinal disaccharidase activity, and anti-stress capacity of weaned gilts. Twenty 42-day-old healthy Duroc × Landrace × Large White weaned gilts (12.84 ± 0.26 kg) were randomly divided into control and treatment (diet containing 1.04 mg/kg ZEA) groups. The experiment included a 7-day pre-trial period followed by a 35-day test period, all gilts were euthanized and small intestinal samples were collected and subjected to immunohistochemical and western blot analyses. The results revealed that inclusion of 1.04 mg/kg ZEA in the diet significantly reduced the activities of lactase, sucrase, and maltase in the duodenum, jejunum, and ileum of gilts. Similarly, the activities of superoxide dismutase and glutathione peroxidase in the duodenum, jejunum, and ileum, and activities of catalase in the jejunum and ileum were reduced (p < 0.05). Conversely, the content of malondialdehyde in the duodenum, jejunum, and ileum, and the integrated optical density (IOD), IOD in single villi, and the mRNA and protein expression of heat shock protein 70 (Hsp70) were significantly increased (p < 0.05). The results of immunohistochemical analyses revealed that the positive reaction of Hsp70 in the duodenum, jejunum, and ileum of weaned gilts was enhanced in the ZEA treatment, compared with the control. The findings of this study indicate the inclusion of ZEA (1.04 mg/kg) in the diet of gilts reduced the activity of disaccharidase enzymes and induced oxidative stress in the small intestine, thereby indicating that ZEA would have the effect of reducing nutrient absorption in these animals.

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Section: Introductionsupporting

confidence: 80%

Effects of Dietary Zearalenone Exposure on the Growth Performance, Small Intestine Disaccharidase, and Antioxidant Activities of Weaned Gilts

Liu

Yang

et al. 2020

Animals

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“…Nazar, Lee [ 137 ] observed reduced embryo cleavage and blastocyst formation in bovine oocytes following exposures to α- and β- ZOL, with stronger effects observed at the higher 30 µmol dose [ 137 ]. ZEN exposure in porcine blastocysts lead to apoptosis, DNA damage, and autophagy [ 138 , 139 ]. Similarly, in porcine embryos, a dose–response relationship was observed between α-ZOL administration and cleavage rates starting at 10 µM, with decreased blastocyst development noted at 30 µM [ 136 ].…”

Section: Resultsmentioning

confidence: 99%

Impact of Fusarium-Derived Mycoestrogens on Female Reproduction: A Systematic Review

Kinkade

Rivera‐Núñez

Gorcyzca

et al. 2021

Toxins

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Contamination of the world’s food supply and animal feed with mycotoxins is a growing concern as global temperatures rise and promote the growth of fungus. Zearalenone (ZEN), an estrogenic mycotoxin produced by Fusarium fungi, is a common contaminant of cereal grains and has also been detected at lower levels in meat, milk, and spices. ZEN’s synthetic derivative, zeranol, is used as a growth promoter in United States (US) and Canadian beef production. Experimental research suggests that ZEN and zeranol disrupt the endocrine and reproductive systems, leading to infertility, polycystic ovarian syndrome-like phenotypes, pregnancy loss, and low birth weight. With widespread human dietary exposure and growing experimental evidence of endocrine-disrupting properties, a comprehensive review of the impact of ZEN, zeranol, and their metabolites on the female reproductive system is warranted. The objective of this systematic review was to summarize the in vitro, in vivo, and epidemiological literature and evaluate the potential impact of ZEN, zeranol, and their metabolites (commonly referred to as mycoestrogens) on female reproductive outcomes. We conducted a systematic review (PROSPERO registration CRD42020166469) of the literature (2000–2020) following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The data sources were primary literature published in English obtained from searching PubMed, Web of Science, and Scopus. The ToxR tool was applied to assess risk of bias. In vitro and in vivo studies (n = 104) were identified and, overall, evidence consistently supported adverse effects of mycoestrogens on physiological processes, organs, and tissues associated with female reproduction. In non-pregnant animals, mycoestrogens alter follicular profiles in the ovary, disrupt estrus cycling, and increase myometrium thickness. Furthermore, during pregnancy, mycoestrogen exposure contributes to placental hemorrhage, stillbirth, and impaired fetal growth. No epidemiological studies fitting the inclusion criteria were identified.

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“…Gene ontology analysis indicated that ZEA exposure resulted in activation of the JAK2‐STAT3 signal pathway in porcine GCs, indicating an involvement of this signaling pathway and downstream targets in the damaging effects (Zhang et al., 2019). Moreover, other researchers have reported that ZEA exposure promotes apoptosis, DNA damage, and autophagy in porcine blastocysts (Yao et al., 2020).…”

Section: Effects Of Zea‐mediated Toxicity In Mammalsmentioning

confidence: 95%

“…A recent study indicated that ZEA leads to oxidative stress in the early porcine embryonic development, which further disrupts mitochondrial function, and mediates apoptosis and autophagy. The antioxidant capacity of melatonin significantly mitigates the negative effect of ZEA, leading to an increase in the rate of formation of porcine blastocysts (Yao et al., 2020).…”

Section: Zea Mitigationmentioning

confidence: 99%

Roles of stress response‐related signaling and its contribution to the toxicity of zearalenone in mammals

Bai

Zhou

Luo

et al. 2022

Comp Rev Food Sci Food Safe

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Zearalenone (ZEA) is a mycotoxin frequently found in cereal crops and cerealderived foodstuffs worldwide. It affects plant productivity, and is also a serious hazard to humans and animals if being exposed to food/feed contaminated by ZEA. Studies over the last decade have shown that the toxicity of ZEA in animals is mainly mediated by the various stress responses, such as endoplasmic reticulum (ER) stress, oxidative stress, and others. Accumulating evidence shows that oxidative stress and ER stress signaling are actively implicated in and contributes to the pathophysiology of various diseases. Biochemically, the deleterious effects of ZEA are associated with apoptosis, DNA damage, and lipid peroxidation by regulating the expression of genes implicated in these biological processes. Despite these findings, the underlying mechanisms responsible for these alterations remain unclear. This review summarized the characteristics, metabolism, toxicity and the deleterious effects of ZEA exposure in various tissues of animals. Stress response signaling implicated in the toxicity as well as potential therapeutic options with the ability to reduce the deleterious effects of ZEA in animals were highlighted and discussed.

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Melatonin alleviates defects induced by zearalenone during porcine embryo development

Cited by 20 publications

References 33 publications

Effects of Dietary Zearalenone Exposure on the Growth Performance, Small Intestine Disaccharidase, and Antioxidant Activities of Weaned Gilts

Effects of Dietary Zearalenone Exposure on the Growth Performance, Small Intestine Disaccharidase, and Antioxidant Activities of Weaned Gilts

Impact of Fusarium-Derived Mycoestrogens on Female Reproduction: A Systematic Review

Roles of stress response‐related signaling and its contribution to the toxicity of zearalenone in mammals

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