Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis

Wang, Xuebin; Bian, Ye; Zhang, R; Li, Xudong; Ni, Leng; Ma, Baitao; Zeng, Rong; Zhao, Ziran; Song, Xiaojing; Liu, Changwei

doi:10.1016/j.bbrc.2019.09.005

Cited by 60 publications

(50 citation statements)

References 29 publications

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“…On the model of bacterial pneumonia, LPS-induced ALI mouse model, it was shown that melatonin successfully inhibits pneumonia through interfering with NLRP3 inflammasome, protecting macrophages from pyroptosis [40]. Other publications also demonstrate that melatonin may be an effective inhibitor of pyroptosis and pathologies associated with it [41][42][43][44][45][46].…”

Section: Coronavirus Activates Inflammasome and Causes Inflammation mentioning

confidence: 99%

Can melatonin reduce the severity of COVID-19 pandemic?

Shneider

Kudriavtsev

Vakhrusheva

2020

International Reviews of Immunology

145

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The current COVID-19 pandemic is one of the most devastating events in recent history. The virus causes relatively minor damage to young, healthy populations, imposing life-threatening danger to the elderly and people with diseases of chronic inflammation. Therefore, if we could reduce the risk for vulnerable populations, it would make the COVID-19 pandemic more similar to other typical outbreaks. Children don't suffer from COVID-19 as much as their grandparents and have a much higher melatonin level. Bats are nocturnal animals possessing high levels of melatonin, which may contribute to their high anti-viral resistance. Viruses induce an explosion of inflammatory cytokines and reactive oxygen species, and melatonin is the best natural antioxidant that is lost with age. The programmed cell death coronaviruses cause, which can result in significant lung damage, is also inhibited by melatonin. Coronavirus causes inflammation in the lungs which requires inflammasome activity. Melatonin blocks these inflammasomes. General immunity is impaired by anxiety and sleep deprivation. Melatonin improves sleep habits, reduces anxiety and stimulates immunity. Fibrosis may be the most dangerous complication after COVID-19. Melatonin is known to prevent fibrosis. Mechanical ventilation may be necessary but yet imposes risks due to oxidative stress, which can be reduced by melatonin. Thus, by using the safe over-the-counter drug melatonin, we may be immediately able to prevent the development of severe disease symptoms in coronavirus patients, reduce the severity of their symptoms, and/or reduce the immuno-pathology of coronavirus infection on patients' health after the active phase of the infection is over. ARTICLE HISTORY

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Section: Coronavirus Activates Inflammasome and Causes Inflammation mentioning

confidence: 99%

Can melatonin reduce the severity of COVID-19 pandemic?

Shneider

Kudriavtsev

Vakhrusheva

2020

International Reviews of Immunology

145

View full text Add to dashboard Cite

show abstract

“…On the model of bacterial pneumonia, LPS-induced ALI mouse model, it was shown that melatonin successfully inhibits pneumonia through interfering with NLRP3 inflammasome, protecting macrophages from pyroptosis [41]. Other publications also demonstrate that melatonin may be an effective inhibitor of pyroptosis and pathologies associated with it [42,43,44,45,46,47].…”

Section: Coronavirus Activates Inflammasome and Causes Inflammation mentioning

confidence: 99%

Can Melatonin Reduce the Severity of COVID-19 Pandemic?

Shneider

Kudriavtsev

Vakhrusheva

2020

Preprint

View full text Add to dashboard Cite

The current COVID-19 pandemic is one of the most devastating events in recent history. The virus causes relatively minor damage to young, healthy populations, imposing life-threatening danger to the elderly and people with diseases of chronic inflammation. Therefore, if we could reduce the risk for vulnerable populations, it would make the COVID-19 pandemic more similar to other typical outbreaks. Children don’t suffer from COVID-19 as much as their grandparents and have a much higher melatonin level. Bats are nocturnal animals possessing high levels of melatonin, which may contribute to their high anti-viral resistance. Viruses induce an explosion of inflammatory cytokines and reactive oxygen species, and melatonin is the best natural antioxidant that is lost with age. The programmed cell death coronaviruses cause, which can result in significant lung damage, is also inhibited by melatonin. Coronavirus causes inflammation in the lungs which requires inflammasome activity. Melatonin blocks these inflammasomes. General immunity is impaired by anxiety and sleep deprivation. Melatonin improves sleep habits, reduces anxiety and stimulates immunity. Fibrosis may be the most dangerous complication after COVID-19. Melatonin is known to prevent fibrosis. Mechanical ventilation may be necessary but yet imposes risks due to oxidative stress, which can be reduced by melatonin. Thus, by using the safe over-the-counter drug melatonin, we may be immediately able to prevent the development of severe disease symptoms in coronavirus patients, reduce the severity of their symptoms, and/or reduce the immuno-pathology of coronavirus infection on patients’ health after the active phase of the infection is over.

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“…Previous studies have demonstrated that melatonin can prevent pyroptosis of cells, such as adipocytes and endothelial cells. 26,27 Herein, we detected the effect of melatonin on diabetes-induced brain injury with a particular focus on neuronal pyroptosis. As illustrated in Figure 2A, melatonin treatment alleviated DM-induced neuronal death as manifested by an increased number of neurons in the brain of diabetic mice.…”

Section: Melatonin Attenuates Neuronal Pyroptosis Both In Vivo and mentioning

confidence: 99%

Melatonin exerts neuroprotective effects by inhibiting neuronal pyroptosis and autophagy in STZ‐induced diabetic mice

Che

Yang

et al. 2020

FASEB j.

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Diabetes mellitus (DM) patients are at a higher risk of developing brain injury characterized by neuronal death. Melatonin, a hormone produced by the pineal gland, exerts neuroprotective effects against brain damage. However, the effect of melatonin on diabetes‐induced brain injury has not been elucidated. This study was to evaluate the role of melatonin against neuronal death in DM and to elucidate the underlying mechanisms. Herein, we found that melatonin administration significantly alleviated the neuronal death in both streptozotocin (STZ)‐induced diabetic mice and high glucose (HG)‐treated neuronal cells. Melatonin inhibited neuronal pyroptosis and excessive autophagy, as evidenced by decreased levels of NLRP3, cleaved caspase‐1, GSDMD‐N, IL‐1β, LC3, Beclin1, and ATG12 both in vivo and in vitro. MicroRNA‐214‐3p (miR‐214‐3p) was decreased in DM mice and HG‐treated cells, and such a downregulation was corrected by melatonin, which was accompanied by repression of caspase‐1 and ATG12. Furthermore, downregulation of miR‐214‐3p abrogated the anti‐pyroptotic and anti‐autophagic actions of melatonin in vitro. Our results indicate that melatonin exhibits a neuroprotective effect by inhibiting neuronal pyroptosis and excessive autophagy through modulating the miR‐214‐3p/caspase‐1 and miR‐214‐3p/ATG12 axes, respectively, and it might be a potential agent for the treatment of brain damage in the setting of DM.

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Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis

Cited by 60 publications

References 29 publications

Can melatonin reduce the severity of COVID-19 pandemic?

Can melatonin reduce the severity of COVID-19 pandemic?

Can Melatonin Reduce the Severity of COVID-19 Pandemic?

Melatonin exerts neuroprotective effects by inhibiting neuronal pyroptosis and autophagy in STZ‐induced diabetic mice

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