Melatonin Alleviated Potassium Dichromate-Induced Oxidative Stress and Reprotoxicity in Male Rats

Abstract

Melatonin (ML) is a potent antioxidant that reduces oxidative stress. This study was designed to examine the protective effect of melatonin on potassium dichromate- (PDC-) induced male reproductive toxicity. Forty rats were divided into five groups: the control group, rats administered PDC orally (10 mg/kg body weight) for eight weeks, rats administered ML intraperitoneally at doses of either 2.5 or 5 mg/kg followed by the administration of PDC, and rats administered 5 mg/kg ML only. The treatment of rats with PDC led to a decrease in the levels of plasma sex hormones, glutathione, superoxide dismutase, catalase, carnitine, sperm count, and motility. Testicular malondialdehyde levels, nitric oxide concentrations, and abnormalities increased significantly in the PDC group. Melatonin administration to the PDC-treated rats reduced the increase of malondialdehyde and restored the activity of antioxidant enzymes (superoxide dismutase and catalase), glutathione, and sex hormone levels. Moreover, ML attenuated PDC-induced increase in levels of tumor necrosis factor-alpha or interleukin-6. ML alleviated histopathological changes and an increase of p53-positive immune reaction due to PDC. Furthermore, ML inhibited PDC-induced decrease in the DNA content of spermatogenic cells. This study proposed that melatonin may be useful in mitigating oxidative stress-induced testicular damage due to potassium dichromate toxicity.

Fagonia indica attenuates chromium-induced nephrotoxicity via antioxidant and anti-inflammatory activities in mice

“…In the current study, at 15 mg/kg/b.wt of POD-intoxicated group III, SOD, GST, and GSH-Px showed a significant decrease compared to control group I (Table 1). These results agree with those of Bashandy et al [28], who showed that daily oral POD treatment for eight weeks in rats caused oxidative stress and a significant reduction in SOD, CAT, and GSH-Px. Additionally, our findings align with those of Kotyk and Iskra [29], who declared that the i.p.…”

“…These results agree with those of Bashandy et al. [ 28 ], who showed that daily oral POD treatment for eight weeks in rats caused oxidative stress and a significant reduction in SOD, CAT, and GSH-Px. Additionally, our findings align with those of Kotyk and Iskra [ 29 ], who declared that the i.p.…”

Protective effects of melatonin against the toxic effects of environmental pollutants and heavy metals on testicular tissue: A systematic review and meta-analysis of animal studies

“…Mice, rats, and hamsters were the subjects of 13 ( 35 – 38 , 43 – 51 ), 24 ( 17 , 39 – 42 , 52 – 70 ), and one ( 71 ) studies, respectively. Studies have utilized heavy metals (n= 12) including arsenic ( 37 , 45 , 67 ), lead ( 58 ), cadmium ( 42 , 47 , 48 , 55 , 68 , 69 ), Hexavalent chromium ( 38 ), and Potassium dichromate ( 52 ) and toxic materials (n= 26) including sodium fluoride (NaF) ( 61 ), 2-Bromopropane ( 54 ), Bisphenol A ( 17 , 43 , 46 , 59 , 62 , 63 , 70 ), thioacetamide ( 56 ), Bisphenol S ( 71 ), ochratoxin A ( 57 ), nicotine ( 49 ), Cigarette smoke ( 39 ), diazinon ( 35 , 36 , 50 ), formaldehyde ( 40 , 60 ), bis(2-ethylhexyl) phthalate (DEHP) ( 44 ), carbon tetrachloride (CCl4) ( 41 , 53 ), Chlorpyrifos ( 65 , 66 ), nonylphenol ( 64 ), and acetamiprid ( 51 ) to induce oxidative stress. To administer the stressors, oral (n= 19) ( 37 , 44 – 46 , 51 , 52 , 57 – 59 , 63 – 72 ), intraperitoneal (n= 14, IP) ( 35 , 36 , 38 , 40 –…”

“…Studies have utilized heavy metals (n= 12) including arsenic ( 37 , 45 , 67 ), lead ( 58 ), cadmium ( 42 , 47 , 48 , 55 , 68 , 69 ), Hexavalent chromium ( 38 ), and Potassium dichromate ( 52 ) and toxic materials (n= 26) including sodium fluoride (NaF) ( 61 ), 2-Bromopropane ( 54 ), Bisphenol A ( 17 , 43 , 46 , 59 , 62 , 63 , 70 ), thioacetamide ( 56 ), Bisphenol S ( 71 ), ochratoxin A ( 57 ), nicotine ( 49 ), Cigarette smoke ( 39 ), diazinon ( 35 , 36 , 50 ), formaldehyde ( 40 , 60 ), bis(2-ethylhexyl) phthalate (DEHP) ( 44 ), carbon tetrachloride (CCl4) ( 41 , 53 ), Chlorpyrifos ( 65 , 66 ), nonylphenol ( 64 ), and acetamiprid ( 51 ) to induce oxidative stress. To administer the stressors, oral (n= 19) ( 37 , 44 – 46 , 51 , 52 , 57 – 59 , 63 – 72 ), intraperitoneal (n= 14, IP) ( 35 , 36 , 38 , 40 – 42 , 47 – 50 , 54 , 56 , 60 , 62 ), and subcutaneous (n= 2, SQ) ( 55 , 63 ) routes were used. To administer melatonin, oral (n= 9) ( 37 , …”

The Concomitant Use o f Melatonin and Bebtelovimab as a Treatment Strategy for Omicron and Future Variants of Concern

“…Spleen cells have also been found to contain melatonin receptors (MT2) [43]. In rodents, including mice, voles, and hamsters, external administration of melatonin has been shown to stimulate the proliferation of spleen cells, with MT2 receptors playing a significant part in this stimulatory impact of melatonin [44]. Treatment with melatonin also promotes T cell proliferation [45].…”