Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials

Rajaratnam, Shanthakumar M W; Polymeropoulos, Mihael H.; Fisher, Dennis M.; Roth, Thomas; Scott, Christin; Birznieks, Ingvars; Klerman, Elizabeth B.

doi:10.1016/s0140-6736(08)61812-7

Cited by 188 publications

(139 citation statements)

References 40 publications

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“…Against this background, the findings of the observational DOPPS are remarkable that self-reported disturbed sleep is a powerful predictor of mortality (85), most tightly related to pain, pruritus, and depression. Melatonin antagonists have recently become available for at least the treatment of transient insomnia after sleep-time shift (86).…”

Section: Disrupted Biorhythmmentioning

confidence: 99%

Cardiovascular Problems on Hemodialysis

Ritz

Bommer

2009

Clinical Journal of the American Society of Nephrology

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Section: Disrupted Biorhythmmentioning

confidence: 99%

Cardiovascular Problems on Hemodialysis

Ritz

Bommer

2009

Clinical Journal of the American Society of Nephrology

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“…For each participant, mean values were calculated separately for the baseline and intervention phases for each for the following sleep parameters: (i) bed and rise times, (ii) total sleep time, (iii) sleep onset latency, (iv) sleep efficiency, and (v) mean activity level. Mean activity level is an indication of the magnitude of activity during sleep and an indirect measure of sleep quality (48,51). For daytime sleepiness, mean KSS scores were calculated for each of the three time points across the wake episodes during baseline and intervention phases.…”

Section: Discussionmentioning

confidence: 99%

“…The minimum sample size required to detect a significant effect in the primary outcome was set to 10 based on our previous laboratory study (51) demonstrating that a 5-hour phase advance of the sleep-wake cycle resulted in a 20% decrease in sleep efficiency (N=8, P=0.007).…”

Section: Discussionmentioning

confidence: 99%

A phase-advanced, extended sleep paradigm to increase sleep duration among early-morning shift workers: a preliminary investigation

Yeung¹,

Rajaratnam²

2010

Scand J Work Environ Health

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Yeung J, Sletten TL, Rajaratnam SM. A phase-advanced, extended sleep paradigm to increase sleep duration among early-morning shift workers: a preliminary investigation. Scand J Work Environ Health. 2011;37(1):62-69 Objective In this preliminary study, using a within-subjects design, we investigated the effects of phaseadvancing bedtime on sleep quality and duration among early-morning shift workers. MethodsThe sleep-wake patterns of 16 healthy volunteers who work shifts with start times between 04.00-07.30 hours were recorded by wrist actigraphy and sleep diary for two weeks. In week 1, we assessed the habitual sleep-wake pattern. In week 2, participants were required to advance their bedtime to 10 hours before the start of the morning shift. Subjective sleepiness was assessed three times each day.Results Total sleep time was longer (1.4 hours) for sleep episodes that occurred prior to days off from work compared to those prior to early-morning shifts. The intervention resulted in bedtime being advanced by 1.5 hours and total sleep time being increased by 1.0 hour, without changes to the latency, efficiency or quality of sleep, or activity level during the sleep episode. A small reduction in daytime sleepiness was found during the intervention phase for assessments taken just prior to bedtime.Conclusions Sleep duration among early-morning shift workers is substantially truncated due to their work schedules. When participants were instructed to advance their bedtime for one week, these individuals were able to increase sleep duration without affecting sleep quality. We suggest longer term studies testing the efficacy of sleep extension as a low-cost, behavioral intervention for improving health and safety outcomes among earlymorning shift workers.

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“…As a more reliable alternative, several drug companies are developing synthetic agents that mimic the effects of melatonin, such as tasimelteon, developed by Vanda Pharmaceuticals in Washington, DC. Klerman and colleagues have shown that tasimelteon can improve sleep quality in time-shifted human subjects 7 , and it is now in a phase III clinical trial for use in blind individuals who lack melanopsin receptors. Such people "have recurrent jetlag", says Klerman, "so they are an ideal population that you would want to try to entrain with melatonin agonists.…”

Section: A Dose Of Rhythmmentioning

confidence: 99%

Chronobiology: Stepping out of time

Eisenstein¹

2013

Nature

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Melatonin agonist tasimelteon (VEC-162) for transient insomnia after sleep-time shift: two randomised controlled multicentre trials

Cited by 188 publications

References 40 publications

Cardiovascular Problems on Hemodialysis

Cardiovascular Problems on Hemodialysis

A phase-advanced, extended sleep paradigm to increase sleep duration among early-morning shift workers: a preliminary investigation

Chronobiology: Stepping out of time

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