Melasma and its association with different types of nevi in women: A case-control study

Adalatkhah, Hassan; Sadeghi‐Bazargani, Homayoun; Amini-sani, Nayereh; Jeddi, Somayeh Zeynizadeh

doi:10.1186/1471-5945-8-3

Cited by 20 publications

(16 citation statements)

References 11 publications

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“…Recent research findings have highlighted the important role of hormones in the pathogenesis of acne. Androgens are believed to contribute to the development of acne, and this theory strengthens more when considering the interactions between sebum production, hirsutism, polycystic ovarian disease, and melasma with acne and androgens 3–7. Considering the pathophysiology of acne, newer steroid-related therapies need to be identified and investigated.…”

Section: Introductionmentioning

confidence: 99%

Flutamide versus a cyproterone acetate-ethinyl estradiol combination in moderate acne: a pilot randomized clinical trial

Adalatkhah

Pourfarzi²,

Sadeghi‐Bazargani³

2011

CCID

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BackgroundThe use of oral flutamide is rarely investigated in acne therapy. The aim of this study was to compare the efficacy of oral flutamide with that of a cyproterone-estradiol combination in treating acne lesions.MethodsA randomized clinical trial enrolled patients with moderate acne into two equal groups to receive either oral flutamide or the cyproterone-estradiol combination for 6 months. Lesion count, Acne Severity Index, and Global Acne Grading system (GAGS) scores were used to assess improvement in acne lesions. The dichotomous measurement scale for primary endpoint assessment was defined as improvement from moderate to mild acne based on GAGS score. Patient satisfaction and dermal fat were also assessed. Intention to treat and per protocol analyses were done, reporting related effect sizes.ResultsBoth treatments resulted in substantial improvement in acne lesions. Although flutamide seemed to have higher efficacy, an intention to treat analysis did not find the two treatment protocols to be different. The relative risk in intention to treat analysis was 1.8 (95% confidence interval [CI] 0.89–1.6), and was 1.33 (95% CI 1.03–1.72) for the per protocol analysis. The number needed to treat for flutamide compared with the cyproterone-estradiol combination was 7.7 and 4.2 in the intention to treat and per protocol analyses, respectively.ConclusionFlutamide appears to be more effective than a cyproterone-estradiol combination in some aspects of acne treatment, but this requires confirmation in a larger trial.

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Section: Introductionmentioning

confidence: 99%

Flutamide versus a cyproterone acetate-ethinyl estradiol combination in moderate acne: a pilot randomized clinical trial

Adalatkhah

Pourfarzi²,

Sadeghi‐Bazargani³

2011

CCID

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“…Hereditary factor may play a role in the causation of melasma. Positive family history of melasma is reported in several studies 26,[30][31][32][33] . Although genetic influence is suggested by a twin study, it is not generally accepted 34,35 .…”

Section: Discussionmentioning

confidence: 87%

“…The results of Passeron et al 25 are in concordance with our study. Approximately 10% of Caucasian patients with melasma, 26% of Indian patients with melasma, 4% of Korean patients with melasma, and 14.5% of Latino patients with melasma were men in the literature [26][27][28] . Sun exposure was the strong aggravating factor in both the groups of patient (86.67% of total patients).…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Efficacy of Glycolic Acid Peel and Intense Pulsed Light in the Treatment of Melasma

Desale¹,

Gugle²,

Kote³

et al. 2015

MVP J Med Sci

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Background: Melasma, one of the common aesthetically displeasing entities, continues to be a difficult problem to treat. Chemical peeling is one new weapon in the therapeutic armamentarium of melasma. Intense Pulsed Light (IPL) is a noncoherent, broad-spectrum light, ranging from 500 to 1200 nm. Intense Pulsed Light (IPL) treatment is a good option for patients with melasma. Aims and Objective: To compare the efficacy of glycolic acid peel and intense pulsed light in the treatment of melasma. Setting: Outpatient department of Dermatology, Venerology Leprology of a tertiary health care centre with an attached medical college. Material and Methods: 60 patients of melasma were recruited in the study. Patients were randomly allocated into two groups: one group (glycolic acid 50%) and another group (IPL) with 30 patients in each group. All the participants were subjected to undergo pre-peel programme of daily application of sunscreens (day time) and 0.025% retinoic acid at bed time for two weeks in GA peel group. 4 peels were carried out at 2 weekly intervals. Four sessions of IPL were done at 3 weeks interval. MASI scoring and coloured photographs (without reavealing identity) of each patient were taken before each peel and at the end of the follow-up period i.e. 2 weeks after 4th sitting in GA peel group and 3 weeks after 4th sitting in IPL group. Side effects, if any, were also recorded. Statistical Analysis Used: SYSTAT version-12. Results: In both the groups there was constant decrease in MASI scores after each sitting as compared to pre-peel scores. However, the comparison of mean MASI scores i.e. both pre-peel and after each peel, between the two groups showed statistically significant difference (p<0.05). Local reactions, such as burning sensation and erythema during the peel were not significant with both the groups. Conclusions: Glycolic Acid (GA) peel (50%) is more efficacious&safe treatment modality in melasma compared to IPL.

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“…Hassan Adalatkhah et al found that existence of some types of nevi specially the lentigenes and melanocytic nevi increase the chance of melasma. 18 Associated dermatological conditions can be attributed to the common etiological factors like sun exposure and hormonal imbalance.…”

Section: Discussionmentioning

confidence: 99%

Clinico Epidemiological and Biochemical Profile of Patients With Melasma

Chandravathi¹,

Soujanya²,

Karani³

2015

jemds

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Melasma and its association with different types of nevi in women: A case-control study

Abstract: Background: Very little is known about possible association of nevi and melasma. The study objective was to determine if there is an association between melasma and existence of different kinds of nevi.

Cited by 20 publications

References 11 publications

Flutamide versus a cyproterone acetate-ethinyl estradiol combination in moderate acne: a pilot randomized clinical trial

Flutamide versus a cyproterone acetate-ethinyl estradiol combination in moderate acne: a pilot randomized clinical trial

Comparative Study of Efficacy of Glycolic Acid Peel and Intense Pulsed Light in the Treatment of Melasma

Clinico Epidemiological and Biochemical Profile of Patients With Melasma

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