Melanotic neuroectodermal tumour of infancy of the jaws: an analysis of diagnostic features and treatment

Abstract

The purpose of this study was to integrate the available published data on melanotic neuroectodermal tumour of infancy (MNTI) of the jaws into a comprehensive analysis of its clinical/radiological features, with emphasis on the predictive factors associated with recurrence. Eligibility criteria included publications with sufficient clinical/radiological/histological information to confirm the diagnosis. A total of 288 publications reporting 429 MNTI cases were included. MNTIs were slightly more prevalent in males and markedly more prevalent in the maxilla. Most of the lesions were asymptomatic, presenting cortical bone perforation and tooth displacement. Nine lesions were malignant, with metastasis in five cases. Enucleation was the predominant treatment (67.2%), followed by marginal (18.4%) and segmental resection (6.1%). Eighty-one of 356 lesions (22.8%) recurred. Recurrence rates were 61.5% for curettage, 25.3% for enucleation alone, 16.2% for enucleation+curettage, 20.0% for enucleation+peripheral osteotomy, 11.3% for marginal resection, 10.0% for segmental resection, 30.0% for chemotherapy, and 33.3% for radiotherapy. Enucleation and resection presented significantly lower recurrence rates in comparison to curettage. Curettage appears not to be the best form of treatment, due to its high recurrence rate. As resection (either marginal or segmental) is associated with higher morbidity, enucleation with or without complementary treatment (curettage or peripheral osteotomy) would appear to be the most indicated therapy.

Idiopathic bone cavity of the jaws: an updated analysis of the cases reported in the literature

“…As there is scarce information in the literature comparing clinicalradiological features of solitary and multiple IBC, this analysis was initially performed, followed by the study of the factors that are associated with persistence following treatment. A review of pathological lesions is important because it provides information that can improve diagnostic accuracy, allowing pathologists and surgeons to make informed decisions and refine treatment plans to optimize clinical outcomes [5][6][7][8][9][10] . In the present review we observed that most of the IBCs occur in There are many published cases of supposed IBC in which the diagnosis was incorrect.…”

Cherubism: a systematic literature review of clinical and molecular aspects

“…The aim of this study was to integrate the available data published in the literature on cherubism. By integrating the available data on each unique condition, it is possible to refine and improve the understanding and definition of each pathological entity, providing valuable information to be used by pathologists, clinicians, and surgeons in the diagnosis and design of the treatment plan [54][55][56][57][58] . In this work, 513 published cases of cherubism were identified and reviewed.…”

Melanotic Neuroectodermal Tumor of Infancy: A Clinicopathological and BRAF V600E Mutation Study of 11 Cases

“…In the current study, MNTI mainly affects the maxilla of male infants, which is consistent with the literature ( 5 , 15 ). Besides the maxilla, other sites, including skull, mandible ( 16 ), and noncranial regions, such as brain, epididymis ( 2 ), mediastinum, femur and ovary ( 4 , 17 ) may be affected. Moreau et al.…”

“…At present, the most common treatment protocol is surgery ( 16 , 23 ). In the present study, enucleation was the predominant treatment (45.4%), followed by curettage (36.4%), partial resection of maxilla (9.1%) and biopsy (9.1%).…”