Melanotic neuroectodermal tumor of infancy (progonoma)—Clinical, radiological, pathological features and literature review

Araújo, Priscila Pereira Costa; Tincani, Álfio José; Paiva, Valeria Pereira; Neta, Iva Santos Loureiro; Cardinalle, Izilda Aparecida; Pereira, Rita; Brandalise, Sílvia Regina

doi:10.1016/j.pedex.2007.03.002

Cited by 4 publications

(2 citation statements)

References 18 publications

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“…Management by wide surgical excision is generally preferred (with at least 5 mm of healthy margins) and it seems essential to reduce the possibility of local recurrence rates to approximately 10%–15%[ 8 ] and usually leads to a good prognosis. [ 9 ] In the absence of free margins, the recurrence rate is increased by five times, most of which occur within 4 months and local radiotherapy with combination chemotherapy is then recommended. [ 8 ] In our case, we had initially resected/enucleated the exophytic lesion with the primary idea of getting a pathological diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Melanotic neuroectodermal tumor of infancy: Does enucleation alone suffice?

Zameer

Rao

Chandrashekar

et al. 2021

J Indian Assoc Pediatr Surg

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Section: Discussionmentioning

confidence: 99%

Melanotic neuroectodermal tumor of infancy: Does enucleation alone suffice?

Zameer

Rao

Chandrashekar

et al. 2021

J Indian Assoc Pediatr Surg

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“…This conservative surgical approach consists of local excision and curettage, and prevents aesthetic sequelae with reduced manipulation of the lesion. While extent of surgical excision is debatable in the literature [ 4 ], the chosen surgical method seems essential to reduce the possibility of local recurrence rates to approximately 10–15% [ 17 , 18 ] and usually leads to a good prognosis [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Melanotic neuroectodermal tumor of infancy in an African-indigenous patient from the Amazon: a case report

Pinheiro

Carneiro²,

Alves

et al. 2013

Head Face Med

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Melanotic neuroectodermal tumor of infancy (MNTI) is a rare condition that occurs normally in the anterior maxilla of infants aged <1 year. The use of clinical and imaging tools for MNTI is extremely important to prevent problems with function as well as the aesthetic features in a breastfeeding child. Brazil is a multiethnic country with a poor epidemiological policy and little data to track the incidence of certain diseases, including MNTI. It is important to study this pathology with ethnicity as a factor to improve the current epidemiological programs and establish better post-treatment management. This paper describes a case of a 2-month-old male of African-indigenous descent and Brazilian Amazon residency, who presented to our unit in 2009 with a history of an expanding mass involving the anterior maxilla. Clinical and computerized tomography scans were used to diagnose the mass as MNTI, which was removed by total excision. A biopsy later confirmed the MNTI diagnosis.

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Mandibular Melanotic Neuroectodermal Tumor of Infancy Treated Conservatively With Enucleation

Piperi¹,

Rake²,

Tosios³

et al. 2010

Journal of Craniofacial Surgery

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Melanotic neuroectodermal tumor of infancy (MNTI) is an uncommon, rapidly growing neoplasm of neural crest origin that primarily develops in the maxilla of infants during their first year of life. Mandibular lesions are rare and account for about 6% of all cases. Radical surgical excision is usually curative, but patients should be followed up closely because recurrence may occur in approximately 10% to 20% of cases. In this study, we report a case of mandibular MNTI in a 4-month-old male patient that was conservatively treated with enucleation and curettage and has shown no recurrence 11 years after surgery. Review of the English-language literature revealed that of more than 350 cases of MNTI reported so far, only 23, including the present one, have been encountered in the mandible. Most patients (91.3%) were younger than 1 year, whereas the male-to-female ratio was 1.3:1. Most lesions were treated with wide surgical excision, with only 2 cases being conservatively treated with enucleation. Recurrence was noted in 36.8% of cases at less than 3 months postoperatively. In conclusion, MNTI lesions in the mandible, albeit rare, show high recurrence rate. However, small-size mandibular MNTI lesions may be successfully treated with conservative enucleation. Close follow-up is highly recommended, in particular during the first 6 postoperative months.

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Melanotic neuroectodermal tumor of infancy (progonoma)—Clinical, radiological, pathological features and literature review

Cited by 4 publications

References 18 publications

Melanotic neuroectodermal tumor of infancy: Does enucleation alone suffice?

Melanotic neuroectodermal tumor of infancy: Does enucleation alone suffice?

Melanotic neuroectodermal tumor of infancy in an African-indigenous patient from the Amazon: a case report

Mandibular Melanotic Neuroectodermal Tumor of Infancy Treated Conservatively With Enucleation

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